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Generx DNA-Based Angiogenic Therapy Receives Russian Ministry of Health Clearance for Late-Stage Registration Clinical Study for Coronary Artery Disease
Date:6/15/2011

ersible perfusion defects of comparable size at one year following these procedures.

An independent long-term study published in Circulation (Meier et al, Circ. 2007; 116:975-983) provided key evidence indicating that men and women with more recruitable collateral circulation have a better chance of surviving a heart attack than patients who have less developed collateral circulation.  This important study quantitatively evaluated coronary collateral blood flow in 845 patients with coronary artery disease during a 10-year follow-up period and showed that long-term cardiac mortality was approximately 66% lower in patients with a highly developed collateral vessel blood supply (p=0.019).  For the first time, this study showed the importance of collateral circulation beyond simply the relief of angina and provided further support of the potential for long term benefits from angiogenic therapy.

"We are pleased to receive clearance from the Russian Ministry of Health and Social Development and look forward to initiating our ASPIRE study with the assistance of the bioRASI organization.  From a global perspective, it is expected that over 80% of the future increase in coronary heart disease mortality will occur outside the U.S., and the economic burden of heart disease is no longer confined to the industrialized world.  With the exception of sub-Saharan Africa, cardiovascular disease is the leading cause of death in the developing world as a result of accelerating tobacco use, diet and lifestyle changes.  There is a need for innovative and cost-effective advanced cardiovascular care to meet the accelerating levels of cardiovascular disease affecting global markets.  A new video "Cardium Generx Cardio-Chant" provides an overview of our Generx product candidate at http://www.youtube.com/watch?v=pjUndFhJkjM.  We believe that Generx may offer the potential fo
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SOURCE Cardium Therapeutics
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