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Generics and Some Brands May Lose $7 Billion Pain Market as Pisgah Labs Develops Abuse Deterrent Products
Date:6/12/2013

assure our partners of the viability to deliver safe and efficacious medications into the pain and ADHD marketplace." Pisgah's technology introduces the abuse deterrent capability at the active ingredient level before it is actually formulated into a dosage presentation, such as a tablet. This approach has been viewed by many as offering additional layers of abuse deterrence by building in the protection from the ground up. Pisgah is also accumulating a number of patent allowances for their novel approach to abuse deterrent pain medications. Bristol added, "As our patents are allowed and issued, the financial component to our product development program provides a sustainable business model for us and to potential marketing partners."

Pisgah Labs was recently granted a U.S. Patent allowance based on an underlying filing entitled "Opioid Salts and Formulations Exhibiting Anti-Abuse and Anti-Dumping Properties." This addition to Pisgah's patent portfolio covers anti-dose dumping characteristics imparted to oxycodone, hydromorphone, and of course, hydrocodone, through specific salt forms of each active. For those wondering just what dose dumping is and why it is of concern, one should first be aware of the potential consequences to the dose-dumping abuser: often its death. Extended or sustained release pain medications contain sufficient active ingredient to maintain pain relief for twelve, and sometimes, twenty-four hours. This amount of narcotic is considerably more than that found in one immediate release tablet that a patient may take every three to six hours depending on need. However, when the higher dosage product is taken in combination with an alcoholic beverage, a phenomenon known as dose dumping can occur, which releases the entire active ingredient dose quickly—a dose which had been intended to release over a half-day or more. The abuser is seeking the gratifying "high," but often encounters respiratory and cardio
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SOURCE Pisgah Laboratories
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