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Generex to Increase Patient Enrollment of its Phase II Breast Cancer Vaccine Study
Date:1/25/2011

rice at which an asset or liability could be exchanged in a current transaction between knowledgeable, unrelated willing parties, and arrived at a value of $300 million. Willing parties are presumed to be marketplace participants representing unrelated buyers and sellers.  Given that Herceptin, which is only available to treat roughly one-third of the patients that would be eligible for AE37, had sales of $1.8 Billion in 2008, the Company believes this estimate to be conservative.  The report did not include or evaluate the potential use of AE37 for treatment of other cancers expressing lower levels of HER2 than are required for use with Herceptin, such as prostate, ovarian, colon, and lung tumors.  Antigen Express recently completed a Phase I study of the AE37 vaccine for prostate cancer and a Phase I study of the AE37 vaccine for ovarian cancer is underway.

Commenting on the AE37 developments, Dr. Eric von Hofe, Ph.D., President of Antigen Express, stated: "We look forward to advancing our Phase II study with these modifications and are excited to have received an independent appraisal demonstrating the current value of this vaccine for breast cancer treatment.  We are confident that our data will provide convincing evidence of the far reaching value of this potentially life saving vaccine."  Dr. von Hofe went on to add: "Given that this low HER2 expression patient population has very limited options and is uniquely eligible for AE37 therapy, it is important to ensure that they are well represented in our ongoing Phase II trial.  The fact that these low HER2 expressing patients can be treated with AE37," continued Dr. von Hofe, "doubles or triples the number of breast cancer patients eligible for AE37 relative to Herceptin."

AE37 represents a new class of self-potentiating peptide vaccines designed to stimulate the immune system to specifically recognize and kill cancer cells.  Antigen Express has previously announc
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SOURCE Generex Biotechnology Corporation
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