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Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer
Date:1/6/2011

velopment."

Antigen Express is developing proprietary vaccine formulations for active immunotherapy and has previously employed a DNA vector approach for silencing expression of the MHC class II-associated invariant chain (Ii protein) in patients with acute myelogenous leukemia. This strategy has been shown to transform cancer cells into specific and potent immunotherapeutic agents to combat cancer in a variety of pre-clinical models.  In addition to hematological malignancies, this strategy is applicable to different types of solid tumors as well, such as colon cancer.

"We are pleased to have generated early compelling data in collaboration with Antigen Express for active immunotherapy with potential oncology applications," said Dmitry Samarsky, Ph.D., Vice President of Technology Development at RXi.  "Our rxRNA™ therapeutic platform may have exciting applications in the development of therapeutic vaccines, and we look forward to the potential for expanding and further developing this opportunity based on our combined approaches."

About Generex Biotechnology Corporation

Generex is engaged in the research, development, and commercialization of drug delivery systems and technologies.  Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs).  The Company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by the lining of the inner mouth using the Company's proprietary RapidMist™ device.  The Company's buccal insulin spray product, Generex Oral-lyn™ is in Phase III clinical trials at several sites around the world.  Antigen Express, Inc. is a wholly owned subsidiary of Generex.  The core platform technologies of Antigen Express comprise immunotherapeutic vaccines for the treatment of malignant, infectious, allergic, and aut
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