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Generex Subsidiary Antigen Express Announces Publication of Review Showcasing its Proprietary Therapeutic Vaccine Technology in the Journal Vaccine
Date:3/14/2012

WORCESTER, Mass. and TORONTO, March 14, 2012 /PRNewswire/ -- Generex Biotechnology Corporation (OTCBB: GNBT) announced today that a review of the Antigen Express proprietary platform technology for generation of immunotherapeutic vaccines has been published in the peer-reviewed journal Vaccine.  The Company is developing therapeutic vaccines for serious unmet medical needs, such as cancer.

The article, entitled "CD4+ T-cell activation for immunotherapy of malignancies using Ii-Key/MHC class II epitope hybrid vaccines", reviews preclinical and clinical studies from the last ten years to the present time demonstrating the importance of generating specific CD4+ T-cell activation in the immunotherapy of cancer.  In addition, the rationale and development of the Company's Ii-Key technology from its discovery in the late 1990's to currently ongoing clinical trials of its lead compound in breast cancer patients is described.

"We are pleased to be able to present our Ii-Key technology in the journal Vaccine," said Dr. Eric von Hofe, President of Antigen Express and senior author of the review. "The technology offers a simple and effective method to potently and specifically increase CD4+ T-cell activation, which on its own is beginning to show signs of clinical efficacy and would certainly augment most other vaccine strategies," he added.

The Company recently released positive interim data from a Phase II efficacy study being performed with its lead Ii-Key compound, AE37, in patients with breast cancer. The study is designed to test for a reduction in relapse in patients who have had standard of care treatment for breast cancer in a controlled and randomized study.

About AE37 and Ii-Key Hybrid Platform Technology
Antigen Express is a platform technology and product-based company developing proprietary vaccine formulations for large, unmet medical needs.  The Company's Ii-Key Hybrid technology platfor
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SOURCE Generex Biotechnology Corporation
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