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Generex Points to Potential of Antigen Express Technology Platform beyond Its AE37 Breast Cancer Vaccine
Date:1/31/2013

ess of activating CD4+ T helper cells requires intracellular processing through processing cells called 'antigen presenting cells'. For example, in infections or cancer, to get the immune Generals, CD4 cells, to attach to a virus or bacteria or cancer, the antigen processing cells will engulf and degrade the virus or bacteria or cancer cell. Ii-Key bypasses the need for intracellular cell degradation and processing, ensuring any payload attached to the Ii key protein will be delivered directly for activation of the immune Generals, CD4+ T cells. In this way, Antigen Express technology essentially hijacks the immune system into going after any given target.

Antigen Express has explored the uses of Ii-Key to deliver a variety of 'payloads' to activate the immune system, both to prove the technology and develop a pipeline. Ii-Key-based lead compounds have been identified for the HER2 protein, being researched in early breast cancer and also proteins in cervical cancer (HPV) and melanoma. The studies describing the activity and preclinical development of those compounds are the subject of peer-reviewed publications. The Company is thus on track to deliver on its business development strategy of demonstrating Phase IIb proof of principle of products in early breast cancer for partnering or licensing as well as offering a proven technology platform for the development of further immune therapy product candidates by potentially adding immune target proteins selected by outside parties to our proprietary Ii key platform.

About Generex Biotechnology Corporation

Generex is engaged in the research, development, and commercialization of drug delivery systems and technologies. Generex has developed a proprietary platform technology for the delivery of drugs into the human body through the oral cavity (with no deposit in the lungs). The Company's proprietary liquid formulations allow drugs typically administered by injection to be absorbed into the body by th
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