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Generex Announces Publication of New Positive Generex Oral-lyn™ Data in Peer-Reviewed Journal
Date:12/13/2010

with a mean age of 52 years, and a body mass index of 33 (i.e. obese) received Generex Oral-lyn™ in equal doses before and 30 minutes after drinking 75 grams of glucose in a standard oral glucose tolerance test.  Glucose and insulin levels were measured at baseline and 30, 60, 90, 120, and 180 minutes after consuming the glucose.  Treatment with an aggregate of 12 Generex Oral-lyn™ sprays resulted in a 29.6% decrease in plasma glucose at two hours and a 26.8% decrease at three hours.  Overall, the study found a mean reduction in glucose levels of 15.8%.  Plasma insulin was also significantly increased at 30 minutes but not at 2 hours or 3 hours, demonstrating the important increase in first phase insulin availability.

The study demonstrates that treatment with Generex Oral-lyn™ is a simple and valuable therapy for reducing post-prandial hyperglycaemia in obese subjects with IGT.  Importantly, the treatment is safe and no subject experienced hypoglycaemia.  Professor Pozzilli commented that:  "The results of this study are of particular interest because they demonstrate that Generex Oral-lyn™ could be successfully employed to normalize post-prandial glucose levels in subjects with IGT.  The convenience of buccal absorption of insulin in subjects with IGT may represent a significant advantage in terms of therapeutic compliance."

Dr. James Anderson, a member of the Generex Scientific Advisory Board, noted that "This study is the first demonstration of directly increasing first phase insulin levels and reducing post prandial glucose using a non-invasive therapy.  The potential to use Generex Oral-lyn™ as a frontline treatment for patients with IGT could have far reaching implications.  If such a non-invasive therapy delayed the onset of diabetes along with all of its complications, it could eventually become a cost effective alternative to allowing the condition to progr
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SOURCE Generex Biotechnology Corporation
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