Gene Therapy Corrects Sickle Cell Disease in Labora...(herapy to produce fetal hemoglobin. We t...),Health

Date:12/3/2008

herapy to produce fetal hemoglobin. We think that increased fetal hemoglobin expression in patients will be well tolerated and the immune system would not reject the hemoglobin, in comparison to other approaches."

While Persons believes that the mouse experiments will lead to treatments in humans, he cautioned that technical barriers still need to be overcome. "It is far easier to achieve high levels of gene insertion into mouse cells than into human cells," he said. "In our mouse experiments, we routinely saw one or two copies of the gamma-globin gene inserted into each cell. However, in humans this insertion rate is at least a hundred-fold less."

Persons' laboratory is currently working with other animal and human cells to develop methods to achieve a high enough gene insertion rate to make the gene therapy clinically useful.

Other authors of this paper include Tamara Pestina, Phillip Hargrove, Dennis Jay, John Gray and Kelli Boyd (all of St. Jude).

This research was supported in part by the National Heart, Lung, and Blood Institute, a Cancer Center Support Core Grant and ALSAC.

St. Jude Children's ResearchHospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit www.stjude.org.

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SOURCE St. Jude Children's Research Hospital Copyright©2008 PR Newswire. All rights reserved

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