Navigation Links
Gene That Causes Childhood Cancer Neuroblastoma Is Found
Date:8/25/2008

rstand the genetic roots of this terrible disease, but also has led to dramatically new ideas for curative therapy."

The study team used high-speed, automated analytic equipment at the Center for Applied Genomics at Children's Hospital. By employing genome-wide scans to analyze DNA from the 10 most informative families with a history of neuroblastoma, Mosse and her colleagues first discovered that a region of chromosome 2 was associated with the disease. Further sequencing of that region identified mutations in the anaplastic lymphoma kinase (ALK) gene in eight families with familial neuroblastoma.

"This finding means that it is possible to offer simple, non-invasive screening for patients with a family history of neuroblastoma," said Mosse. She explained that ultrasound or a urine test could assist surveillance of children with an ALK mutation, so that if neuroblastoma appears, it can be detected at an early stage. "As we increase our knowledge of ALK mutations, we will also offer specialized diagnostic testing for all newly diagnosed patients with neuroblastoma, to eventually allow oncologists to better customize treatment to a child's genetic profile."

After detecting ALK mutations in familial neuroblastoma, the researchers then focused on the more common sporadic (non-familial) cases of neuroblastoma, and found that ALK mutations occurred in 12 percent of 194 tumor samples from the aggressive, high-risk form of the disease.

Although the normal role of the ALK gene is not well understood, other researchers had previously found that abnormalities in ALK raise a patient's risk for lymphoma and lung cancer. "We were the first to identify mutations in ALK," said Mosse, adding that in lymphoma and lung cancer, ALK acts through translocation, a different mechanism that involves an exchange of DNA between chromosomes to produce a new cancer-causing fusion gene.

In all three cancers, ALK acts as an oncogene, or cancer-causing gene; in f
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Seventy Years Old and Going Strong With Down Syndrome and No Dementia: The Case of Mr. C Causes Major Interest in the Scientific Community
2. SuperGens PIM Kinase Inhibitor, SGI-1776, Causes Tumor Regression in AML Xenograft Models
3. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
4. Mayo Clinic Study Identifies Potential Causes of Young-Onset Dementia
5. Gen-Probe Begins U.S. Clinical Study of Molecular Test for Human Papillomavirus, Which Causes Cervical Cancer
6. UNICEF Partners With Causes on Facebook to Launch Charity Gift Feature
7. St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory
8. Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer
9. The COSHAR Foundation Launches National Childhood Immunization Awareness Campaign During National Infant Immunization Week (April 19-26)
10. St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia
11. St. Jude Finds Signaling System That Halts the Growth of a Childhood Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014  Commonwealth Cornerstone Group (CCG) today announced the completion ... Tuesday to help fund the expansion and consolidation of healthcare ... Sharon . PHN is the largest ... . It is the largest employer in Sharon,s ... on staff. Currently, PHN Sharon offers scattered services ...
(Date:12/24/2014)... 2014  The International Trade Commission (ITC) issued its final ... Medical. In a notice issued on December 23, the ITC ... on its humidifier was invalid. BMC President, ... are very excited with the ITC,s decision in this case. ... taken since the very beginning on the key patents in ...
(Date:12/24/2014)... LONDON , December 24, 2014 /PRNewswire/ ... expected to grow at an average rate of 8.1%. ... and volume. Hip, knee and spine surgeries are the ... emerging economies they have a lower penetration. Increased number ... use of composites. Non-metallic orthopedic devices have gained popularity ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 This ... state of the global Sterilizers industry with a focus ... on the market status of the Sterilizers manufacturers and ... companies and individuals interested in the industry. This report ... definition, applications and manufacturing technology. In this part, the ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast ... treatment landscape, unmet needs, current pipeline and commercial opportunities ... drug which is typically used for treating colorectal cancer. ... treating gastric cancer and pancreatic cancer. TS-1 is composed ... first approved in 1999 in Japan for the treatment ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of ... its new selection of black one-shoulder cocktail dresses . ... they are available at discounted prices, up to 70% off. ... last for three weeks only. You know, we have thousands ... interested in our new items can visit our website for ...
(Date:12/25/2014)... Recently, BellasDress has launched its ... dresses. BellasDress has chosen their best-selling lace wedding dresses, ... the holiday season. , Now, BellasDress.com features popular ... here at discount prices. The business hopes everyone can ... , “All our elegant products are made ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... performance and lifestyle brand is paired with LensCrafters, ... 500 North American stores, MASON, Ohio, June ... at more than 500 select LensCrafters locations, North ... customers the,combined benefits of Oakley,s popular and innovative ...
... The Pennsylvania Breast Cancer Coalition announces special press,availability ... 12 The following is,being issued by the ... PA Breast Cancer Coalition (PBCC) and the Pennsylvania ... a Homerun Derby event,sliding through each of the ...
... treating high cholesterol, researchers say , , THURSDAY, June 12 ... found a protein in the liver involved in regulating ... provide a new target for treating high cholesterol or ... factor that regulates lipid synthesis in the liver," said ...
... up with Crohn,s & Colitis Foundation of America for this year,s ... Take ... of America (CCFA) is happy to announce that Salix,Pharmaceuticals, a leader in gastroenterology, ... 4 p.m. starting with family,festivities in Overland Park, Kansas a suburb of Kansas ...
... Light Technology and Ancient Relaxation ... Sleep Assistant, PORTLAND, Ore., June 12 For ... sleep but find traditional remedies such as drugs,sound machines ... Resources, Inc. is announcing the first sleep-assisting device,that silently ...
... International (VMI),recently donated a wheelchair-accessible Honda Odyssey ... Foundation. American Honda Motor Co., Inc., (AHM),supplied ... Northstar conversion, which,provides a powered in-floor ramp ... all types of wheelchairs., (Photo: ...
Cached Medicine News:Health News:Oakley Prescription Eyewear Now at Lenscrafters 2Health News:Oakley Prescription Eyewear Now at Lenscrafters 3Health News:Oakley Prescription Eyewear Now at Lenscrafters 4Health News:Scientists Discover Protein Involved in Fat Production 2Health News:National Pharmaceutical Company to Sponsor Popular Kansas City Walk 2Health News:National Pharmaceutical Company to Sponsor Popular Kansas City Walk 3Health News:New Drug-Free Solution for Insomnia 2Health News:Sam Schmidt Receives a Honda Odyssey Converted for Wheelchair Accessibility 2Health News:Sam Schmidt Receives a Honda Odyssey Converted for Wheelchair Accessibility 3
NS2000 Bipolar Generator provides precise coagulation without tissue sticking....
The Sabre 2400 provides high power performance and key user features to meet today's demanding electrosurgical needs. It is an ideal general-purpose electrosurgical generator....
The ExcaliburPlus PC is the most powerful isolated ESU with 10,000 V PTP in spray coag....
Standard bipolar coagulator...
Medicine Products: