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Gene Findings Unlocking Reasons for Neuroblastoma Risk
Date:6/22/2009

fe for children with this complex disease. The Cancer Center at Children's Hospital has one of the nation's largest research and clinical programs in pediatric oncology.

DNA samples for both studies were provided by the Children's Oncology Group, a multicenter collaborative research organization in which Maris chairs the committee overseeing basic and clinical research in neuroblastoma. A variety of funding sources supported both studies, including the National Institutes of Health, the Alex's Lemonade Stand Foundation, the Evan Dunbar Foundation, the Rally Foundation, the Andrew's Army Foundation, the Abramson Family Cancer Research Institute and the Giulio D'Angio Endowed Chair.

Maris is also on the faculty of the University of Pennsylvania School of Medicine. Scientists from six other centers in addition to Children's Hospital and the University of Pennsylvania contributed to the discovery or replication of the findings.

Capasso et al, "Common variations in BARD1 influence susceptibility to high-risk neuroblastoma," Nature Genetics, published online May 3, 2009.

(http://dx.doi.org/10.1038/ng.374)

Diskin et al, "Copy number variation at 1q21.1 associated with neuroblastoma," Nature, published June 18, 2009. (http://dx.doi.org/10.1038/nature08035)

About The Children's Hospital of Philadelphia

The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research
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SOURCE The Children's Hospital of Philadelphia
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