Genasense Plus Chemotherapy Is Associated With Prolonged Survival in Patients With Relapsed/Refractory CLL Who Achieve Complete... (ients who achieved CR in the Phase 3 tri...)

HOME >> MEDICINE >> TECHNOLOGY

Genasense Plus Chemotherapy Is Associated With Prolonged Survival in Patients With Relapsed/Refractory CLL Who Achieve Complete Remission

Date:12/10/2007

ients who achieved CR in the Phase 3 trial. Previously, a survival benefit had been demonstrated only in CR patients who were prospectively stratified prior to randomization as being "non-refractory" to chemotherapy using a standard definition. (The prior data can be accessed at: http://www.genta.com/index.php?option=com_content&task=view&id=60&Itemid=73 &CI D=44&SHID=&COID=). (To view this Web site please cut and paste the URL into your browser.) The new data show that this superior survival benefit for Genasense-treated patients extends to all patients who achieved CR/nPR. These data are presented in the table below.

Survival Genasense/Flu/Cy Flu/Cy p-value

1 year 20 8 0.016

2 years 17 8 0.06

3 years 16 4 0.005

4 years 12 2 0.006

Safety

Grade 3 or Grade 4 adverse events that occurred during treatment or within 30 days from last treatment in an increased percentage of patients in the Genasense group included, but were not limited to, thrombocytopenia, nausea, and intravenous-catheter complications. Adverse events resulted in discontinuation of therapy in an equal percentage of patients in both groups. Nine patients in the Genasense group and 5 patients in the chemotherapy-alone group had adverse events that resulted in death, including two patients in the Genasense group who died from complications associated with tumor lysis and infusion-related reactions.

A scientific report of the safety and efficacy findings from this study was published earlier this year in the Journal of Clinical Oncology (25:1114, 2007).

Regulatory History of Genasense in CLL

Genta
'/>"/>

SOURCE Genta Incorporated
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6
Related medicine technology :

1. Genta Initiates Phase 3 AGENDA Trial of Genasense(R) for Patients with Advanced Melanoma
2. Genasense(R) Data in Melanoma to be Presented in Opening Session at First Worldwide Melanoma Center Meeting of the European Association of Dermato-Oncology
3. Authorization for AGENDA Phase 3 Trial of Genasense(R) in Advanced Melanoma Granted by French Regulatory Agency
4. Genasense(R) Can be Administered by Brief High-Dose IV Infusion
5. Genasense(R) Data in Patients with Advanced Melanoma to be Featured at 4th International Melanoma Congress
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
8. Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
9. Tablet PC Technology Helps Doctors and Patients Focus on Chemotherapy Side Effects, According to Thomson Healthcare Study
10. Promising Data from Paratek Pharmaceuticals MAR Inhibitor Program Presented in Late Breaker Session at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
11. Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

Post Your Comments:

(Date:5/22/2013)... , May 22, 2013 ... is investigating claims on behalf of investors of Intuitive ... ISRG ) (CUSIP: 46120E602) who purchased Intuitive Surgical ... 2013 (the "Class Period"). Such investors are advised to ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ...

(Date:5/22/2013)... GROVE, Minn. , May 22, 2013 ... announced the successful completion of its global ... topiramate), an internally developed program for the ... company,s proprietary formulation technology. USL255 is specifically ... reduce fluctuations in topiramate blood levels observed ...

(Date:5/22/2013)... and TORONTO , May 22, 2013 ... today announced three presentations demonstrating the superiority of the ... subsidiary, Antigen Express, Inc. ( www.antigenexpress.com ). The presentations ... American Society of Clinical Oncology (ASCO) to be held ... through June 4, 2013. The presentation entitled ...

Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG 2 Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 2 Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 3 Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 4 Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 2 Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 3 Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 4

[0] SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG [0] Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures [0] Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine

... 60 medical technology manufacturers from across the United States ... AdvaMed 2011: The MedTech Conference today. Innovative ... will make 9-minute company presentations to hundreds ... capital investors, and other strategic partners at the Walter ...

... 2011 ( http://www.myprgenie.com ) -- Texans for Stem ... announces the panel of stem cell experts from Texas ... at the TSCR Second Annual Educational Symposium with a ... Chancellor for Health Affairs for The University of Texas ...

Cached Medicine Technology:Update: Innovative Companies to Present at AdvaMed 2011: The MedTech Conference Today in Washington, D.C. 2 Update: Innovative Companies to Present at AdvaMed 2011: The MedTech Conference Today in Washington, D.C. 3 Update: Innovative Companies to Present at AdvaMed 2011: The MedTech Conference Today in Washington, D.C. 4 Update: Innovative Companies to Present at AdvaMed 2011: The MedTech Conference Today in Washington, D.C. 5 World-Class Stem Cell Pioneers Collaborate & Educate at Texans for Stem Cell Research 2nd Annual Symposium In Austin 2 World-Class Stem Cell Pioneers Collaborate & Educate at Texans for Stem Cell Research 2nd Annual Symposium In Austin 3 World-Class Stem Cell Pioneers Collaborate & Educate at Texans for Stem Cell Research 2nd Annual Symposium In Austin 4 World-Class Stem Cell Pioneers Collaborate & Educate at Texans for Stem Cell Research 2nd Annual Symposium In Austin 5

Update: Innovative Companies to Present at AdvaMed 2011: The MedTech Conference Today in Washington, D.C.World-Class Stem Cell Pioneers Collaborate & Educate at Texans for Stem Cell Research 2nd Annual Symposium In Austin

(Date:5/22/2013)... TWITTER: @the_USO & @SesameStreet ... to 8 countries in the next 6 months! ... Members of Congress came together to show their heartfelt thanks to ... Care Packages for distribution to our servicemen and women. ... of Sesame Street and the USO as well as the success ...

(Date:5/22/2013)... 2013 Zensah® Compression Apparel released a ... titled "Breast pain while running affects one-third ... could help." According to the article, a British study ... amount suffer from breast pain while running but do ... issue. , Zensah emphasizes the importance for women ...

(Date:5/22/2013)... Successful Therapy for Parents program, ... in the Silver Lake community of Los Angeles ... progression to existing Parents and Couples counseling programs. ... therapy has always been suggested, but now it's ... specializes in all aspects of relationships ...

(Date:5/22/2013)... Twenty student-led startup companies at Arizona State University ... startup accelerator designed to help them execute their business ... jobs as part of ASU’s Edson Student Entrepreneur ... approximately 20 student teams up to $20,000 each in ... their for-profit, more-than-profit or nonprofit ventures. The program, which ...

(Date:5/22/2013)... WEDNESDAY, May 22 (HealthDay News) -- Migraines and depression ... new research indicates the combination of the two may ... brain. , , Already aware that people with migraines ... determine if having both conditions together affected total brain ... -- isn,t alarming, study authors said, but needs further ...

[0] The USO and Sesame Street Announce Spring Kick Off of World Tour at Biannual Care Package Service Project Event in DC [0] Zensah® Comments on New York Daily News Article Examining How Better Sports Bra Could Help Women Marathoners [0] Patricia O’Laughlin Psychotherapy of Los Angeles Now Seeing Adults, Teens and Young Children [0] ASU Announces Edson Student Entrepreneur Initiative’s 2013-2014 Cohort [0] Having Both Migraines, Depression May Mean Smaller Brain

... Patients with gynecologic cancer have new hope in a ... at University Hospitals (UH) Case Medical Center. A ... is among the first in the nation to launch ... treat ovarian, endometrial and select other cancers. Performed ...

... News) -- Americans with access to three key ... risk of death, according to a new study. ... and weekend office hours, the University of California, ... for new health problems, preventive care and referrals ...

... HealthDay Reporter , FRIDAY, Jan. 20 (HealthDay News) ... between asthma medication use during pregnancy and common birth defects. ... between some rare birth defects and mothers with asthma, and ... out whether the problem was a loss of oxygen from ...

... , THURSDAY, Jan. 19 (HealthDay News) -- Sexual activity ... American Heart Association says in a new statement. ... and be aware that heart problems could spell trouble ... not controlled. The heart association also cautions ...

... News) -- Job-related injuries and illnesses in the United States ... to a new study. The figure is much higher ... direct and indirect costs of all cancers, $76 billion more ... the costs of stroke, the researchers say. "It,s ...

... of p53 and Mdm2 is closely related. In an article ... Robin Fahraeus and his collaborators from Inserm Unit 940 ("Therapeutic ... requires involvement from the protein kinase ATM so that Mdm2 ... focus is placed on protein p53 in cancer research. Discovered ...

Cached Medicine News:Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 2 Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 3 Health News:Study Highlights Features of High-Quality Primary Care 2 Health News:Asthma Meds Likely Safe During Pregnancy: Study 2 Health News:Asthma Meds Likely Safe During Pregnancy: Study 3 Health News:Sex OK for Many Heart Patients, Docs Say 2 Health News:Sex OK for Many Heart Patients, Docs Say 3 Health News:U.S. Work-Related Injuries, Illnesses Take Toll on the Till 2 Health News:3 is the magic number: A chain reaction required to prevent tumor formation 2

UH Case Medical Center offers new therapy for gynecologic cancer patients Study Highlights Features of High-Quality Primary Care Asthma Meds Likely Safe During Pregnancy: Study Sex OK for Many Heart Patients, Docs Say U.S. Work-Related Injuries, Illnesses Take Toll on the Till 3 is the magic number: A chain reaction required to prevent tumor formation

... optics. The separation of illumination and observation ... system avoids corneal and iris reflex (Gullstrand-principle). ... the whole of the illuminated section of ... Conventional ophthalmoscopes often let you see only ...

... an innovative and patented new optical ... enabling technology makes it easier to ... dramatically wider, more panoramic view of ... ever before achieved with a standard ...

RT-600 Refractor...

Illuminated Phoroptor Refracting Instrument. Illumination is provided by a cool-running, energy efficient LEDs (Light Emitting Diodes) that light only what you need to see without affecting the darke...

Medicine Products:

2.5V Ophthalmic BETA 200 Pro Welch Allyn PanOptic Ophthalmoscope RT-600 Illuminated Phoroptor