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Genasense Plus Chemotherapy Is Associated With Prolonged Survival in Patients With Relapsed/Refractory CLL Who Achieve Complete Remission
Date:12/10/2007

Updated Phase 3 Results Released at American Society of Hematology Meeting

BERKELEY HEIGHTS, N.J., Dec. 10 /PRNewswire-FirstCall/ -- Genta Incorporated (Nasdaq: GNTA) announced the release of new survival analyses based upon extended follow-up of patients in the Company's randomized Phase 3 trial of Genasense(R) (oblimersen sodium) Injection for relapsed or refractory chronic lymphocytic leukemia (CLL). The new data show that patients who achieved complete remission (the primary endpoint of the trial) with Genasense plus chemotherapy have shown extended survival compared with patients whose complete remission was induced with chemotherapy alone. The data were released this weekend at a press briefing sponsored by the American Society of Hematology (ASH) and will be presented in a scientific session on Tuesday December 11, 2007 at the ASH annual meeting in Atlanta, GA by Dr. Susan O'Brien, Professor of Medicine, M.D. Anderson Cancer Center, Houston, TX.

The new data show that the median survival of patients treated with Genasense plus chemotherapy who achieved complete remission (CR, defined as complete plus nodular partial response) has still not been reached but currently exceeds 55+ months, compared to a median of 45 months in the chemotherapy-alone group. Of 20 patients in the Genasense group who achieved CR, 12 (60%) remain alive compared with 3 of the 8 patients who achieved CR with chemotherapy alone (38%). With a minimum follow-up of 54 months, 9 of the 12 CR patients in the Genasense group have not required additional therapy, and 5 (25%) remain in continuous CR. In the chemotherapy-alone group, all 3 survivors who previously achieved CR have relapsed, and all have required additional anti-leukemic
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SOURCE Genta Incorporated
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