Navigation Links
Genaera Presents Preliminary Phase 1b Data for Trodusquemine (MSI-1436)
Date:2/10/2009

-Cohort 1 Data Promising for Type 2 Diabetes-

PLYMOUTH MEETING, Pa., Feb. 10 /PRNewswire-FirstCall/ -- Genaera Corporation (Nasdaq: GENR) today reported promising preliminary Phase 1b clinical data for trodusquemine (MSI-1436), the first-in-class, highly selective inhibitor of PTP1B and Genaera's lead drug candidate for the treatment of type 2 diabetes and obesity. Mr. Jack Armstrong, President and CEO of Genaera, presented data from the first of three cohorts in an ascending multiple dose study of MSI-1436 (Study 102), during the BIO CEO & Investor Conference in New York.

Data from cohort 1, in which eight doses of 3 mg/m2 of MSI-1436 were administered over 21 days to overweight and obese type 2 diabetic subjects, demonstrated meaningful improvement in four primary outcomes used to evaluate type 2 diabetes, including:

  • A 9.5% decrease in fasting blood glucose with a resulting 17% differential compared to placebo subjects in the same cohort;
  • A 7% decrease in the area under the curve during the oral glucose tolerance test;
  • An 11.3% decrease in serum fructosamine, which is used to monitor short-term (2-3 weeks) blood sugar control; and
  • A 0.4% decrease in hemoglobin A1C (HbA1C), used to monitor longer-term (2-3 months) blood sugar control.

"It is very exciting to see a believable biologic response to MSI-1436 in cohort 1 of Study 102. While 3 mg/m2 of drug was thought to be a sub-therapeutic dose, the data has demonstrated otherwise. We are currently completing the in-house portion of the second cohort of this study evaluating 6 mg/m2 of MSI-1436 and the initial results support proceeding to the 10 mg/m2 cohort which will begin later this month. Final Study 102 data is expected in the second quarter," comme
'/>"/>

SOURCE Genaera Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Genaera Presents Promising Preclinical Data for Trodusquemine (MSI-1436) at Keystone Symposia
2. Genaera Begins Phase 1b Trial of Trodusquemine (MSI-1436) in Overweight and Obese Type 2 Diabetics
3. Genaera Corporation Reports Phase 1 Data for Trodusquemine (MSI-1436) at the North American Association for the Study of Obesity Annual Meeting
4. Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit
5. Genaera Corporation Presents Data on Mechanism of Inhibition of PTP-1B for Trodusquemine (MSI-1436) at Federation of American Societies for Experimental Biology (FASEB) Meeting
6. Genaera Corporation Presents Additional Promising Preclinical Type 2 Diabetes Data for Trodusquemine (MSI-1436) at American Diabetes Association
7. Genaera Corporation Announces MSI-1436 Data Presented at Society of Neuroscience Meeting
8. Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma
9. Genaera Corporation Presents Promising Preclinical Type 2 Diabetes Data for Trodusquemine (MSI-1436) at Keystone Symposia
10. Genaera Announces Diabetes IND In Effect for Trodusquemine (MSI-1436)
11. Genaera Begins Dosing Second Phase 1 Trial of Type 2 Diabetes and Obesity Compound Trodusquemine (MSI-1436)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , July 2, 2015 Numotion,s Board of ... announced that Tamas Feitel has joined the ... Numotion after a highly successful 18 year career at ... driving strategy, profitability, and productivity to result in significant ... position was Chief Financial Officer for GE Healthcare Global ...
(Date:7/2/2015)... DURHAM, N.C. , July 2, 2015 /PRNewswire/ ... acquisition of assets related to the ion channel biology ... had previously been obtained as part of Pfizer,s 2011 ... of Pfizer,s rights to the "Icagen" name and trademark. ... provide comprehensive services for ion channel and transporter drug ...
(Date:7/2/2015)... -- Konica Minolta, Inc. (Konica Minolta) ( Tokyo ... Technologica Ltda., an X-ray system equipment manufacturer based in ... Brazilian healthcare sales company, Konica Minolta Healthcare do ... Brazil market investment and growth With ... significant healthcare technical advancements and efficiencies are required. Aging ...
Breaking Medicine Technology:Numotion Names Tamas Feitel Chief Financial Officer 2Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 2Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 3Icagen Re-launched through XRpro Sciences Acquisition of Pfizer Team and Technology for Ion Channel and Transporter Drug R&D 4Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3
... Emirates, Feb. 10, 2011 Mafraq Hospital ... (Nasdaq: MASI ) jointly announced the ... Pulse CO-Oximetry™ technology for advanced noninvasive patient monitoring capabilities. ... the UAE to feature Masimo,s technologically and clinically-advanced oximetry ...
... 2011 When the ODT Forum is held in Memphis ... help to shape industry innovation, standards and methods. The ODT ... where orthopedic device manufacturers can discuss the critical issues they ... will be held at the FedEx Institute of Technology and ...
Cached Medicine Technology:Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 2Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 3Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 4Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 5Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 6Mafraq Hospital Becomes First in United Arab Emirates to Deploy Masimo rainbow SET Pulse CO-Oximetry for State-of-the-Art Noninvasive Patient Monitoring 7ODT Forum Returns to Memphis with Unique Opportunity for Orthopedic Manufacturers 2
(Date:7/4/2015)... ... July 04, 2015 , ... Chronic Neck Pain. ... pain sufferers have pain located in the neck. Another 19% suffer from head, migraine, ... Chiropractic literature suggests that 45% of American workers must deal with neck pain. ...
(Date:7/3/2015)... ... ... Hope Food Bank will hopefully be getting a large donation of canned food items ... Greenville SC are making it their mission to collect as many canned items as possible. ... from the public as well. As part of the canned food drive, these local chiropractors ...
(Date:7/3/2015)... Greenville, SC (PRWEB) , ... ... ... Society has announced the sessions and speaker lineup for its 2015 ... nursing, taking place August 6-8, 2015 at the Renaissance Orlando at SeaWorld ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. E. Smith, the only ... lead a national president recruitment for Regional Care, Inc. in Scottsbluff, ... E. Smith has recently placed more than 1,000 healthcare executives into organizations. ...
(Date:7/3/2015)... ... 03, 2015 , ... Smoothies are all the rage right now and all ... quality ingredients. Aurora Natural is proud to introduce a new line of all natural ... antioxidants, vitamins and minerals! , Aurora is offering a variety of blends and stand-alone ...
Breaking Medicine News(10 mins):Health News:New Advancement in Treatment of Chronic Neck Pain 2Health News:New Advancement in Treatment of Chronic Neck Pain 3Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 2Health News:Greenville Area AlignLife Offices to do a Thanksgiving in July Food Drive 3Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 2Health News:RNS Announces Sessions and Speaker Lineup for the 2015 Annual Conference of the Rheumatology Nurses Society 3Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Aurora Product, Inc. Announces An Original New Line: Smoothie Fixins’ 2
... ... global leader in strategic consulting, was named a 2009 “Purveyor of the Year” by ... has provided Outback Steakhouse with custom, strategic learning solutions to help cascade strategies throughout ... ...
... Innovative ... around the globe. , ... (PRWEB) April 9, 2010 -- CareCloud today announced that it has been selected ... innovative solutions are “disrupting the established enterprise and pioneering cloud computing and SaaS.” The ...
... Gastrointestinal (GI) chronic perforations require closure and control ... stents or plastic stents are an effective ... have many drawbacks. Using the newly designed ... bleeding to close two chronic inveterate external gastric ...
... Women should get retested whenever they change sexual partners, ... -- Once-a-year screening for chlamydia isn,t likely to protect ... A new study has found that most cases of ... chlamydia infection when they were screened, which suggests they ...
... ... emergency medical cache of disposable medical supplies, ready for quick use by patients and ... (PRWEB) ... of preparing for the possibility of a large scale health emergencies. Healthcare organizations need ...
... ... with the apps Rx for a busy life. ,Life gets hectic. Heck, ... mobile applications for iPhone, iPod touch, and the new IPad is on ... your busy life less stressful, less complicated and yes… more productive! Rooted ...
Cached Medicine News:Health News:Root Learning Named “Purveyor of the Year” For Strategic Partnership with Outback Steakhouse 2Health News:CareCloud Ranked Among Top SaaS Companies 2Health News:Yearly Chlamydia Screening May Be Ineffective for Some 2Health News:Provide Medical Surge Care with MasCache by DQE 2Health News:Dr. Appz Launches Comprehensive Productivity App for iPhone 2
The Model 340 is intended for continuous pulse oximetry and has visual and audible alarms to aid with patient monitoring....
... inserting a finger into comfortable holder, ... and continuous measurement is performed., ... height. In darker surroundings, back light ... ,Light weight, compact contour and ...
... The FingerPrint Sleep Hand-Held Pulse ... specifically designed for sleep screening studies ... or home. With its easy-to-use, ... reliable spot-checking measurements of SpO 2 ...
... BCI Oximetry Data Management Program is a ... the FingerPrint Sleep Hand-Held Pulse Oximeter. ... #3389 Interface Cable, it rapidly downloads information ... and/or related studies, and assists in the ...
Medicine Products: