Navigation Links
Genaera Corporation Presents Preclinical Trodusquemine (MSI-1436) Data at the North American Association for the Study of Obesity Annual Meeting
Date:10/23/2007

betes and obesity. By inhibiting PTP-1B, trodusquemine has been shown to decrease appetite and normalize blood sugar as PTB-1B is central to both the insulin and leptin pathways. Based on this unique mechanism of action, trodusquemine has the potential to bridge the treatment for two of the most serious metabolic diseases, type 2 diabetes and obesity. In addition, trodusquemine has overcome selectivity concerns that other compounds that target PTP-1B have failed to overcome. Preclinical studies demonstrate that trodusquemine is a potent, highly selective and reversible inhibitor of PTP-1B. In vitro kinetics demonstrate that trodusquemine is a reversible, allosteric, noncompetitive inhibitor of PTP-1B, binding to a site different from the catalytic site of PTP-1B. Data also demonstrate that trodusquemine can produce consistent, sustainable weight loss in a variety of animal models and appears to overcome metabolic readjustment, which often limits sustained weight loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction of lean mass), and improves glucose tolerance via inhibition of a unique combination of signaling pathways in a mouse model of diet induced obesity (DIO).

About Genaera

Genaera Corporation is focused on advancing the science and treatment of metabolic diseases. The Company has significant market opportunities with a first-in-class molecule, trodusquemine (MSI-1436), that has the potential to redefine the treatment paradigm for obesity and type 2 diabetes and is presently in a Phase 1 trial in obesity. In addition, Genaera has a value-driven, fully out-licensed partnership with MedImmune, Inc. for a second core program that is presently undergoing Phase 2 clinical testing in asthma. Genaera is committed to directing resources to its core program and the aggressive clinical development of its key assets to build stockholder value.

SOURCE Genaera Corporation
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
2. Genaera to Present Preclinical Data on Trodusquemine for the Treatment of Obesity at the American Diabetes Association 67th Scientific Sessions
3. Alfacell Corporation to Present at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
4. Millipore Corporation Announces New ReNcell Data from Collaboration with ReNeuron
5. NanoBio Corporation Announces Positive Phase 1 Clinical Results for Topical Treatment for Onychomycosis
6. Alba Therapeutics Corporation Reports Preliminary Phase IIa Clinical Trial Results for AT-1001 for the Treatment of Celiac Disease
7. EpiCept Corporation to Present New NP-1 Data at American Pain Society Meeting
8. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
9. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
10. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
11. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... MEDITE Group acquired by CytoCore, Inc. (OTCBB: CYOE) ... rd quarter sales ended September 30, 2014 of $8.7 ... nine months ended September 2014 and a $38,000 loss for ... quarter is usually a seasonable weak period due to ... for many countries worldwide, we are proud to announce record ...
(Date:11/22/2014)... CHAPEL HILL, N.C. , Nov. 21, 2014 ... the healthcare system. Undoubtedly, the growing influence of ... and spend for marketing interactions. Now, more than ... and retain patients for medical products is essential. ... benchmarking firm, Best Practices, LLC, benchmarked companies spent ...
(Date:11/21/2014)... VIENNA, Va. , Nov. 21, 2014 /PRNewswire/ ... operates in Southern California , today ... caregiving technology. Alta will be providing the innovative BeClose ... services. Logo - http://photos.prnewswire.com/prnh/20141121/160143LOGO ... to providing the kind of affordable 24/7 care our ...
Breaking Medicine Technology:CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Alta Home Care, Inc. and BeClose Partner to Enable Seniors to Remain in Their Homes Safely and Securely 2
... INDIANAPOLIS, Dec. 9, 2011   Lilly for Better Health ™, ... ) that helps individuals live healthier, more active lives, has ... The newly enhanced En Espanol section ... practical tips on healthy eating, physical activity and managing health ...
... 2011 NHS National Innovation Centre supports ... Sequana Medical announced today the findings of an ... the National Innovation Centre, the NHS organization which supports ... and use of innovations that will benefit the NHS. ...
Cached Medicine Technology:Lilly for Better Health™ Expands Website to Include Spanish Health Information and Interactive Tools 2Lilly for Better Health™ Expands Website to Include Spanish Health Information and Interactive Tools 3NHS National Innovation Centre Estimates Sequana Medical's ALFApump® System Could Save the NHS £50 Million in ascites Care Annually 2
(Date:11/22/2014)... BambooFlooringChina.com is a famous brand in the bamboo flooring ... of bamboo mats ; the new models are offered ... , According to the sales manager of BambooFlooringChina.com, Bamboo is ... renewable resource. Their bamboo mats are 100% made from natural ... natural bamboo with caramel bamboo strips. , “Bamboo ...
(Date:11/22/2014)... 2014 “Due to my knee replacement surgery, ... Gurnee, Ill. “While using the ice grip attachment, I noticed ... there needed to be a safer way to prevent possible ... , The SPIKE BLOCK offers added safety and stability in ... to reduce injuries and damage associated with traditional spiked ice ...
(Date:11/22/2014)... November 22, 2014 Nocturia is ... the complaint that the individual has to wake ... The report “Nocturia – Pipeline Review, H2 2014” ... Nocturia, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:11/22/2014)... 22, 2014 Domestic farmgate milk ... in 2009-10, due to a fall in demand ... industry products amid the global financial crisis. However, ... of Australian dairy manufacturers on the international scene. ... outweighed supply growth, primarily due to supply constraints ...
(Date:11/22/2014)... Lipitor lawsuits ( http://www.lipitorlawsuitcenter.com/ ) that ... developed Type 2 diabetes due to its use continue ... underway in U.S. District Court, District of South Carolina, ... litigation will convene its next Status Conference on December ... Counsel for Plaintiffs and Defendants to meet and confer, ...
Breaking Medicine News(10 mins):Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3
... ... of cognitive fitness for improved longevity , ... NEW YORK (PRWEB) March 30, 2010 -- CogniFit™, Inc., a leading maker ... in the field of longevity, author and speaker, is now an official spokesperson for CogniFit. ...
... ... on elder care law, released this statement concerning a March/April AARP article entitled "Love is ... married for 44 years was forced to divorce in order to protect their remaining savings ... completely off the mark , ...
... ... EHR/PM solution to area physician practices , ... Dallas, TX (Vocus) March 30, 2010 -- Aprima Medical ... revenue cycle management solutions for medical practices, today announced a value-added reseller agreement with ...
... of the sex hormones, testosterone in men and estrogen ... regenerative potential of cartilage tissue. The study suggests hormone ... might be beneficial in treating late stages of human ... this evidence-based study appear in the April issue of ...
... fatal and others much less severe is largely a ... variability can be attributed to differences in how individuals ... the Society for General Microbiology,s spring meeting in Edinburgh ... tool to allow treatments to be tailored to individuals. ...
... less likely to breast-feed than other women , ... breast-feeding may explain why black American women are less ... new study shows. , About 60 percent of black ... 77 percent of white infants, according to the researchers, ...
Cached Medicine News:Health News:CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness 2Health News:CogniFit and Longevity Expert Cooperate to Raise Awareness for the Benefits of Brain Fitness 3Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 2Health News:Prominent National Elder Law Attorney Disputes AARP Article Recommending Divorce to Afford Health Care 3Health News:Aprima and ProviDyn, Inc. Partner to Provide Electronic Health Records to Georgia Medical Practices 2Health News:Hormone replacement in joint fluid has potential regenerative effect 2Health News:Personalizing medicine to prevent pandemics 2Health News:Black Women in U.S. Comfortable With Formula Feeding 2
Sterile squares of smooth foil for repair of the floor of the orbit and other plastic surgery. Available in large size....
Segment stand magnifiers come complete with bar magnifier to achieve a higher magnification while still maintaining a wide binocular field of view....
The Multi-Purpose Stand Magnifier is the most versatile stand magnifier. The stand has multiple configurations allowing for all situations where hands-free magnification is needed....
Contour design eyelid implants....
Medicine Products: