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Genaera Corporation Presents Preclinical Trodusquemine (MSI-1436) Data at the North American Association for the Study of Obesity Annual Meeting
Date:10/23/2007

PLYMOUTH MEETING, Pa., Oct. 23 /PRNewswire-FirstCall/ -- Genaera Corporation (Nasdaq: GENR) announced today the presentation of preclinical data on its Phase 1 product candidate for obesity, trodusquemine (MSI-1436), at the North American Association for the Study of Obesity (NAASO) Annual Meeting in New Orleans, Louisiana.

The poster presentation of preclinical data shows that MSI-1436 demonstrated selective inhibition of PTP-1B but did not inhibit the activities of DDP-IV, TC-PTP or SHP-2 nor inhibit ligand binding to the CB1 or 5HT2C receptors. Additional in vitro testing demonstrated that MSI-1436 does not activate PPAR (alpha, beta/delta or gamma) nor bind to 250 different kinases. In an animal model, MSI-1436 was found to distribute to both the liver and brain upon peripheral administration and was observed to modify the phosphorylation status of downstream effectors of insulin signaling.

The study confirmed that MSI-1436 is a selective inhibitor of PTP-1B, and its central and peripheral effects provide promise for the simultaneous treatment of both type 2 diabetes and obesity.

The poster at NAASO entitled, "Trodusquemine is a Protein Tyrosine Phosphatase 1B Inhibitor that Causes Differential Weight Loss," will be presented today from 9:00 a.m. to 2:30 p.m., Central Time. Researchers from Genaera will be at the poster from 1:00 p.m. to 2:30 p.m. to answer any questions.

About Trodusquemine

Trodusquemine (MSI-1436) is the first drug candidate that acts both centrally and peripherally to selectively inhibit the established and validated enzyme target, protein tyrosine phosphatase 1B (PTP-1B). The dual locations of MSI-1436 action make the drug a promising candidate for both type 2 dia
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SOURCE Genaera Corporation
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