Navigation Links
Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
Date:8/19/2007

steady flow of clinical information in the second half of 2007 as our clinical studies progress to broader populations."

About Trodusquemine (MSI-1436)

Trodusquemine (MSI-1436) is the first drug candidate that acts both centrally and peripherally to selectively inhibit the established and validated enzyme target, protein tyrosine phosphatase 1B (PTP-1B). The dual locations of MSI-1436 action make the drug a promising candidate for both obesity and type 2 diabetes. By inhibiting PTP-1B, trodusquemine is expected to decrease appetite and normalize blood sugar as PTB-1B is central to both the insulin and leptin pathways. Based on this unique mechanism of action, trodusquemine has the potential to bridge the treatment for two of the most serious metabolic diseases, obesity and type 2 diabetes. In addition, trodusquemine has overcome selectivity concerns that other compounds that target PTP-1B have failed to overcome. Preclinical studies demonstrate that trodusquemine is a potent, highly-selective and reversible inhibitor of PTP-1B. In vitro kinetics demonstrate that trodusquemine is an allosteric, noncompetitive inhibitor of PTP-1B, binding to a site different from the catalytic site of PTP-1B. Data also demonstrate that trodusquemine can produce consistent, sustainable weight loss in a variety of animal models and appears to overcome metabolic readjustment, which often limits sustained weight loss during caloric restriction. Trodusquemine suppresses appetite, causes differential weight loss, reduces adipocyte size, reduces body fat (with no reduction of lean mass), and improves glucose tolerance via inhibition of a unique combination of signaling pathways in a mouse model of diet induced obesity (DIO).

About Genaera

Genaera Corporation is focused on advancing the science and treatment of metabolic diseases. The Company has significant market opportunities with a first-in-class molecule, trodusquemine (MSI-1436), that has the potential to redefin
'/>"/>

SOURCE Genaera Corporation

Copyright©2007 PR Newswire.

Page: 1 2 3 4

Related medicine technology :

1. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
2. Genaera to Present Preclinical Data on Trodusquemine for the Treatment of Obesity at the American Diabetes Association 67th Scientific Sessions
3. Alfacell Corporation to Present at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
4. Millipore Corporation Announces New ReNcell Data from Collaboration with ReNeuron
5. NanoBio Corporation Announces Positive Phase 1 Clinical Results for Topical Treatment for Onychomycosis
6. Alba Therapeutics Corporation Reports Preliminary Phase IIa Clinical Trial Results for AT-1001 for the Treatment of Celiac Disease
7. EpiCept Corporation to Present New NP-1 Data at American Pain Society Meeting
8. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
9. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
10. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
11. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... is pleased to announce the appointment of Dr. ... Biochemistry. Scott joins the company after previous scientific leadership positions ... course of his nearly 20 year career in therapeutics ... recognized thought leader in the biosensor field and particularly ...
(Date:1/22/2015)... , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ... focus on Omega-3 therapies for cardiovascular disease and overall health ... Company,s accomplishments in 2014 and its outlook for 2015 from ... Fellow Shareholders, We would like to take this ...
(Date:1/22/2015)... , Jan. 22, 2015  Profil Institute for Clinical ... diabetes and obesity, announced today a new textbook,  Translational ... published by Springer, a leading global scientific publisher. ... and illustrate techniques for use in early phase clinical ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3
... Techniques -PHILADELPHIA, Feb. 26 Discovering ... like searching in the proverbial haystack for an unknown number ... into the background, and many of them widely separated from ... other by fine threads, you might pull out clumps of ...
... discomfortLAS VEGAS, Feb. 26 Tying a shoe, ... The mobility of our fingers and wrists can often ... pain begins, and interferes with simple, everyday tasks. According ... the American Academy of Orthopaedic Surgeons (AAOS) ( ...
Cached Medicine Technology:The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 2The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 3The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs 4Got Pain? 2Got Pain? 3Got Pain? 4
(Date:1/22/2015)... Liberty University has received accreditation for its resident Clinical ... for Accreditation of Counseling & Related Educational Programs (CACREP). ... & Family Studies , is under the leadership of Dr. ... Behavioral Sciences. Prior to the formation of the new school, ...
(Date:1/22/2015)... 2015 Woodloch Pines, an all-inclusive family ... by TripAdvisor as the number one best large hotel for ... the world for their annual Travelers’ Choice Awards. , ... The website is home to millions of unbiased and honest ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who ... are thrilled to have it lead the wedding dress industry ... of prom dresses for the global market. , “The CEO ... and he focuses on continuing the goal of operational excellence ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue ... means to “Live Fearless.” , The “Faces of ... stories about how they or someone they know has faced ... in the moment. By telling these types of stories through ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Juvent Sports ... at the 2015 PGA Merchandise Show to bestow a ... incredible female amateur golfer, Arlene McKitrick. The award commemorated ... amateur golf tournament win. She won her first amateur ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3
... This release is available in Spanish . ... spite of the noteworthy advances of recent decades, women continue to ... elderly, disabled or the sick. In general, traditional family care ... workplace and the decrease in the number of housewives, the increase ...
... ... dental practice in the Chicago suburbs, introduces new user-friendly Web site to increase convenience and ... Chicago, ... suburban residents can find a top Downers Grove, Bolingbrook, Lombard or Wheaton dentist , ...
... help spur skin cancer, but industry says it,s not so ... calls for the U.S. Food and Drug Administration to clamp ... as an agency panel debates new restrictions on the devices, ... are hoping the FDA will reclassify tanning beds," said Dr. ...
... ... Niles, IL uses both Eastern and Western medicine to treat virtually every type of ... physical therapy, chiropractic care, manual therapy, acupuncture, pain management, and other techniques tailored to ... ...
... ... held by Diet Coke and The Heart Truth., , ... (PRWEB) March 25, 2010 -- US Wellness and Spokesperson Heidi Klum ... 19, as part of a year long campaign to raise heart disease awareness and give ...
... The ... Online Strategy to Promote National Mental Health Awareness Campaign , ... St. Louis, MO (PRWEB) March 25, 2010 -- The Karla ... friends with a loved one suffering from mental illness and those who have lost a ...
Cached Medicine News:Health News:Women bear caregiving responsibility in cases of dependency in Spain 2Health News:Women bear caregiving responsibility in cases of dependency in Spain 3Health News:Leading Downers Grove Dentist Team at Grove Dental Launches New Web Site 2Health News:FDA Panel Weighs New Restrictions on Tanning Beds 2Health News:FDA Panel Weighs New Restrictions on Tanning Beds 3Health News:FDA Panel Weighs New Restrictions on Tanning Beds 4Health News:East Meets West at a Chicago Area Health Clinic 2Health News:East Meets West at a Chicago Area Health Clinic 3Health News:US Wellness Joins Diet Coke, The Heart Truth and Heidi Klum to Bring Awareness to Heart Disease 2Health News:The Net Impact Creates Website for St. Louis Event to Combat the Stigma of Mental Illness 2Health News:The Net Impact Creates Website for St. Louis Event to Combat the Stigma of Mental Illness 3Health News:The Net Impact Creates Website for St. Louis Event to Combat the Stigma of Mental Illness 4
... tool for the Humphrey Field Analyzer, ... and shows less inter-test variability than ... degree of reproducibility as Full Threshold ... correlate with the earlier glaucoma damage ...
... can trust its capabilities will expand ... and glaucoma therapy in one system. ... the optimal system for photocoagulation, post-cataract ... The push of a button is ...
... non-mydriatic fundus camera increases ... of fundus imaging. Compact, ... set the standard in ... a unique combination of ...
... is the new disruption laser from ... for applications in posterior capsulotomy (post-cataract ... laser is also used for trabeculotomy, ... It's another milestone in the development ...
Medicine Products: