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Gelesis Unveils Novel Non-Invasive Capsulated Device for Obesity and Presents Clinical Data; Appoints Former Pfizer R&D President to Board
Date:4/22/2010

stitute Professor at the Massachusetts Institute of Technology and world leader in polymeric materials. "This opens the door for entirely new uses of polymers in medicine and offers hope in treating obesity which has become a serious health issue."  

To measure its effect on satiety, Drs. Roberto Tacchino and Serena Marchisella at the Gemelli Hospital in Rome, Italy administered Attiva™ to 95 normal, overweight, and obese subjects with an average BMI (Body Mass Index) of 31.  Subjects received two grams of Attiva™ versus placebo before breakfast, lunch, and dinner, in a double-blind, cross-over study.   Satiety was assessed using a self-administered questionnaire immediately, and 30 and 60 minutes after meals.

The results show that Attiva™ significantly increased the post-meal feeling of satiety, in addition to being safe and well-tolerated.  At 30 minutes after breakfast and dinner, and at 60 minutes after lunch and dinner, Attiva™ achieved significantly higher satiety scores versus placebo.  In addition, subjects who took Attiva™ prior to the start of lunch reported feeling less hungry prior to dinner. These results offer hope that Attiva™ could be a potential breakthrough approach to weight management and obesity.

"This is an exciting new approach to tackling obesity," said Dr. James Hill, Professor of Medicine & Pediatrics at the University of Colorado, and Past President of The Obesity Society (TOS), "This new hydrogel is an innovative way to effectively increase satiation while decreasing food consumption."

Attiva™ is currently under development by

SOURCE Gelesis, Inc.
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