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Gegevens over één jaar van wereldwijd register voor atriumfibrillatie (AF) tonen dat antitrombosemiddelen niet optimaal worden gebruikt ter voorkoming van beroertes
Date:9/3/2013

aten te waarborgen voor patiënten en populaties.  

Het register is gestart in december 2009. Vier kritische ontwerpelementen van het GARFIELD-protocol waarborgen een brede en representatieve omschrijving van AF:

  • Vijf sequentiële cohorten van prospectieve, voor het eerst gediagnosticeerde patiënten, waarmee vergelijkingen van afzonderlijke tijdsperioden mogelijk worden gemaakt en de evolutie van behandelingen en uitkomsten wordt beschreven.
  • Onderzoekslocaties die willekeurig worden geselecteerd uit zorgvuldig aangewezen nationale instellingen voor AF-zorg, waarmee wordt gewaarborgd dat de deelnemende patiëntenpopulatie representatief is.
  • Deelname van opeenvolgende in aanmerking komende patiënten, ongeacht de toegepaste therapie om potentiële vooroordelen bij de selectie te vermijden.
  • Gegevens van de nazorg worden minimaal 2 en maximaal 8 jaar na de diagnose vastgelegd, om een alomvattende database op te zetten van behandelingsbesluiten en uitkomsten in de alledaagse klinische praktijk.

Deelnemende patiënten zijn binnen de laatste zes weken gediagnosticeerd met non-valvulaire AF en hebben minstens één extra risicofactor voor een beroerte, en zijn als zodanig kandidaten voor therapie met anticoagulantia ter voorkoming van bloedstollingen die leiden tot een beroerte. Het wordt aan het klinische oordeel van de onderzoeker overgelaten om de risicofactor(en) van patiënten voor een beroerte te identificeren. Patiënten kunnen deelnemen, ongeacht of zij therapie met anticoagulantia krijgen, zodat huidige en toekomstige behandelingsstrategieën en -mislukkingen en de relatie met de risicoprofielen en comorbiditeiten van de patiënten goed kunnen worden geïnterpreteerd.

Er worden gegevens verzameld over een uitgebreide periode van nazorg van maximaal 8 jaar en de volg
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SOURCE Thrombosis Research Institute
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