Navigation Links
Gamma-Tocotrienol Kills Prostate Cancer Stem Cells
Date:7/25/2010

SINGAPORE, July 25 /PRNewswire-Asia/ -- Scientists from Singapore, Australia and Hong Kong have found that gamma-tocotrienol is potent in killing prostate cancer stem cells. This small group of cells is responsible for the initiation of prostate cancer and is resistant to conventional chemotherapy drugs. It causes relapses in the cancer by producing new chemo-resistant cancer cells. Gamma-tocotrienol is a member of the Vitamin E family and is derived naturally from palm oil.

This study aimed to find a way to eradicate prostate cancer stem cells. It follows an earlier report that demonstrated the effectiveness of gamma-tocotrienol in targeting the bulk of the prostate tumour mass. This latest finding highlights the considerable potential of gamma-tocotrienol as a natural remedy to prevent and treat prostate cancer.

This research study involves collaboration between scientists at Davos Life Science (Singapore) and researchers at Australian Prostate Cancer Research Centre -- Queensland and The Hong Kong University. The findings were reported in the latest edition of the International Journal of Cancer (IJC).

The scientists found that low doses of gamma-tocotrienol cause apoptosis in the prostate cancer stem cells and suppress their colony formation capability. This results in a lower prostate cancer stem cell population (as defined by the protein markers CD133 and CD44). Further tests in mice models were conducted, where mice implanted with hormonal refractory prostate cancer cells were given gamma-tocotrienol orally. The results showed that gamma- tocotrienol not only reduced tumour size formed, but also decreased the incidence rate of tumour formation by 75%, as compared to the control group of mice, which had 100% tumour formation. These results strongly suggest that gamma-tocotrienol could be developed for prostate cancer prevention and treatment.

"Current chemotherapy drugs, such as Docetaxel, have limited effect on prostate cancer stem cells, although they are currently the first-line drug given to patients with advanced hormonal refractory prostate cancer. This study shows that gamma-tocotrienol is effective in preventing the formation of prostate tumours in mice models. The key compound involves the use of a natural product, gamma-tocotrienol, which is found in edible plant oils, thereby minimising potential adverse side effects," said Dr. Daniel Yap, one of the leading scientists for the study and Head of Research & Development at Davos Life Science. "As gamma-tocotrienol has shown positive results in removing the stubborn prostate cancer stem cells, it should be investigated as a more effective form of treatment strategy to achieve what conventional chemotherapy drug has failed to do -- to keep the disease in remission state."

"These results provide a compelling case for developing the potential of gamma-tocotrienols to help patients with terminal hormonal refractory prostate cancer. The prospects of future studies on the cancer-fighting effects of gamma-tocotrienols are exciting indeed and we see increasing research interest by scientists in this area," said Mr. Arthur Ling, CEO of Davos Life Science Singapore.

About Davos Life Science

Davos Life Science was established in 2004 as the world's largest tocotrienol manufacturer. The company extracts natural palm tocotrienols for use in health supplements, functional foods, personal care products and pharmaceutical formulations under the brand name "Natural e3". The company has also set up the world largest research and development centre dedicated to tocotrienols. For more information, please visit http://www.davoslife.com


'/>"/>
SOURCE Davos Life Science
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Vision Problems Affect How Children Learn Math Skills
2. Nanoemulsion Kills Highly Resistant Bacteria Found in Patients With Cystic Fibrosis
3. Program Improves Language Skills in Deaf, Hard of Hearing
4. Hand Washing with 4% CHG Antiseptic Kills Flu Viruses
5. Information-Motivation-Behavioral Skills Analysis Advances Understanding of Barriers to Self-Monitoring of Blood Glucose
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Use it or Lose it: A New Theory About Preserving Erectile Function After Prostate Surgery
8. Gene Fusion Subtypes in Prostate Carcinoma Have Clinical Implications
9. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
10. Peregrine Reports Data Showing Bavituximabs Potential to Shrink Prostate Tumors
11. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... , February 12, 2016 ... anders vermerkt)   http://www.sedar.com ) ... http://www.telestatherapeutics.com abrufbar.    --> ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss des zweiten ...
(Date:2/12/2016)... Feb. 12, 2016  Sequent Medical, Inc. announced today ... to evaluate the safety and effectiveness of the WEB™ ... ruptured intracranial aneurysms.  Prof Laurent Spelle , MD, ... Paris, France and Principal Investigator of ... France and Germany.  Although patients with ...
(Date:2/12/2016)... -- OMS Supply, a large provider of oral surgery supplies ... recent launching of their new company website. The OMS ... enhance the user experience and enable practitioners to browse ... --> --> Despite the fact that ... in early 2016, they have already made an unprecedented ...
Breaking Medicine Technology:
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker of coconut water beverages ... GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature ... event. The invitation-only gifting suite, held this year at the W Hollywood Hotel, has ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare ... San Francisco General Hospital on April 5-7. The series is a multi-day, multi-workshop ... habits. The workshops cover a broad range of topics, including coaching skills, the ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured ... West Penn Burn Center, part of the Allegheny Health Network, has partnered ... you the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” ...
(Date:2/12/2016)... ... 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with offices ... raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and 3rd ... in a low-income area and has more than 60 2nd and 3rd graders with ...
(Date:2/12/2016)... ... , ... Vail knee specialist Robert LaPrade, MD, PhD was named ... list consists of physicians establishing, leading and partnering with ambulatory surgery centers across the ... Surgery Center, also known as an ASC, is a modern health care facility focused ...
Breaking Medicine News(10 mins):