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Galenea and CHDI Foundation Announce Collaboration to Identify Key Synaptic Dysfunction in Huntington's Disease
Date:9/6/2011

ing brain and behavioral activities in parallel.  The collaboration will employ this two-pronged approach to identify and characterize the synaptic defects that occur in HD at both the neuronal and network levels.  

"We are pleased to be collaborating with CHDI who bring deep expertise and resources to the collaboration.  Our vision is to translate initial discoveries that emerge from this critical first step into novel drug candidates that positively impact the lives of Huntington's disease patients," said Mark Benjamin, DSc, Galenea's President and CEO.  David Gerber, PhD, VP of CNS Research added, "The opportunity to apply Galenea's platform to the discovery of synaptic-based therapeutics for HD is ideal.  I am confident that this collaboration will yield new insights into the underlying pathology of this disease and ultimately new therapeutic candidates."

About Huntington's disease

Huntington's disease is an inherited neurodegenerative disorder caused by a mutation in the huntingtin gene. The defect causes a DNA sequence called a CAG repeat to occur many more times than normal. Each child of a parent with a mutation in the huntingtin gene has a 50% chance of inheriting the mutation. As a result of carrying the mutation, an individual's brain cells degenerate leading to behavioral, cognitive, and motor impairments that, over the course of the disease, significantly reduce the individual's quality of life and ultimately cause death within 15 to 25 years of overt symptom onset. There are currently no therapeutics approved that slow the progression of Huntington's disease. It is estimated that the disorder affects about 30,000 people in the United States and at least 150,000 others have a 50% risk of developing Huntington's disease at some point.

About CHDI Foundation, Inc.

CHDI Foundation, Inc. is a privately-funded, not-for-profit, biomedical research organization exclusively dedica
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SOURCE Galenea Corp.
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