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Galenea and CHDI Foundation Announce Collaboration to Identify Key Synaptic Dysfunction in Huntington's Disease
Date:9/6/2011

CAMBRIDGE, Mass. and NEW YORK, Sept. 6, 2011 /PRNewswire/ -- Galenea Corp. and CHDI Foundation, Inc. have announced a collaboration to identify synaptic dysfunction linked to Huntington's disease (HD) utilizing Galenea's proprietary synaptic transmission drug discovery platform.  Mounting evidence indicates that mutant huntingtin protein, the molecular defect in HD, disrupts normal synaptic function, contributing to the behavioral, cognitive, and motor symptoms of this devastating neurodegenerative disorder.  Galenea's innovative platform will provide new insights into the disease mechanism and, ultimately, offer a different approach to the discovery of therapies for HD.

"The application of Galenea's high throughput platform to investigate synaptic transmission dysfunction in HD will be very informative to developing drugs that target, in a very precise way, the molecular underpinnings of cognitive and behavioral defects in HD," said Ramee Lee, PhD, Director, Early Discovery Initiative at CHDI. "We are excited to work with Galenea to determine whether EEG signatures in rodent HD models are reflective of the synaptic dysfunction seen in HD patients. Such information could significantly facilitate HD preclinical drug discovery efforts," added George Yohrling, PhD, Director, Target Assessment at CHDI.

Dysfunctions in synaptic transmission, the fundamental process by which neurons communicate, play a critical role in many central nervous system diseases, including HD.   Galenea's platform examines synaptic transmission on multiple levels.  Galenea's MANTRA ™ (Multiwell Automated Neuro TRansmission Assay) system, a revolutionary high throughput screening assay, monitors synaptic events at the cellular level using primary neuronal cultures.  At the network level, Galenea has developed a state-of-the-art system for establishing in vivo electroencephalography (EEG) measures of behaviors in rodent disease models by monitor
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SOURCE Galenea Corp.
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