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Galenea Announces Publication Describing High Throughput Screening System for Modulators of Synaptic Function
Date:10/6/2011

rom a set of pharmacologically defined compounds.  Screening with MANTRA demonstrated that a number of these compounds mediate their pharmacological effects by specific and previously unknown actions on presynaptic function. The extension of the MANTRA system to genomic screening should uncover new drug targets that will impact not only basic neuroscience research but also drug discovery and development.

"This publication highlights the pioneering work performed by my collaborators at Galenea," stated Timothy Ryan, PhD, Professor of Biochemistry at Weill Cornell Medical College and a co-author of the paper.  "The MANTRA system is a major technological achievement and has significant applications for advancing our understanding of the synaptic dysfunctions associated with many CNS disorders."

About Galenea

Galenea is a leader in the rapidly emerging field of synaptic transmission (ST), the process by which neurons communicate with each other.  Dysfunctions in ST are now widely believed to play a central role in many psychiatric, neurological and neurodegenerative diseases, and modulators of ST therefore have the potential to yield breakthrough treatments. Galenea has developed an innovative ST drug discovery platform that integrates three components: MANTRA™, a high throughput, proprietary screening technology to identify a new generation of small molecule modulators of synaptic transmission; in vivo models using integrated EEG measures of animal behavior to more reliably determine CNS drug efficacy; and human EEG biomarkers, developed in tandem with and informed by our animal EEG data to greatly enhance CNS drug development.   The company is advancing a novel pro-cognitive program derived from the platform and the approach can be extended to address multiple CNS disorders.  Based in Cambridge, MA, Galenea has assembled a compelling scientific team, balancing academic aptitude with industry experience and en
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SOURCE Galenea Corp.
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