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Galderma Announces Interim Data Relating to Sequential Treatment Regimen of Clobex(R) Spray Followed by Vectical(TM) Ointment in Managing Plaque Psoriasis
Date:3/6/2009

- Interim Findings To Be Presented in a Poster Session at the 67th Annual Meeting of the American Academy of Dermatology -

SAN FRANCISCO, March 6 /PRNewswire/ -- Galderma Laboratories, L.P. today announced interim findings from a study of sequential treatment of plaque psoriasis using Clobex(R) (clobetasol propionate) Spray 0.05% followed by treatment with Vectical(TM) (calcitriol) Ointment 3mcg/g. The results of an interim analysis of the data are to be presented in a poster session at the 67th Annual Meeting of the American Academy of Dermatology on March 8th at 10:30 a.m. PT. The poster can be found under reference number 3362.

While both Clobex Spray and Vectical Ointment are indicated for the treatment of plaque psoriasis, this study was conducted to confirm the safety and efficacy of these products when used in a sequential regimen. In this study, Clobex Spray was used in the initial phase of the study to treat moderate to severe plaque psoriasis. For subjects sufficiently clear at the end of 4 weeks, Vectical Ointment was applied twice-daily for 8 weeks. Success was evaluated at week 12 based on Overall Disease Severity (ODS) scores.

The interim results indicate that sequential treatment of plaque psoriasis with Clobex Spray followed by Vectical Ointment is effective in managing plaque psoriasis over a 12-week period. Additionally, the interim results demonstrate that this sequential treatment regimen was well tolerated, with the most commonly reported side effects including mild to moderate pruritus (itching), stinging and burning and telangectasias (small dilated blood vessels near the surface of the skin).(1)

"The recent availability of Vectical Ointment fulfills an important unmet need for patients who do not have access to a steroid-free ointment that can help manage their condition both safely and effectively over the long-term," said Mark Lebwohl, M.D., Department o
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SOURCE Galderma Laboratories, L.P.
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