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GSK research estimates significantly higher rates of pertussis among older adults than now reported
Date:9/12/2013

PHILADELPHIA, Sept. 12, 2013 /PRNewswire/ -- The incidence of pertussis among U.S. adults 50 and older may be greatly under-reported and under-recognized, according to findings from a study conducted by GlaxoSmithKline (NYSE: GSK; LSE: GSK) researchers who analyzed approximately 48 million cases of cough-related illness in the U.S. between 2006 and 2010. The findings were released today at the 2013 Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).

Two GSK researchers, using a multiple linear regression model, estimated that the actual number of pertussis cases was approximately 520,000 versus the 8,764 medically-attended cases among U.S. adults ages 50 to 64, and approximately 465,000 versus 6,359 medically-attended pertussis cases among adults 65 and older in the same database.  

That equates to an incidence on average of 202 per 100,000 in adults 50-64, and 257 per 100,000 among adults 65 and older. These estimated incidences were about 42 to 105 times higher than the medically-attended pertussis cases documented in the same database during the years 2006-2010. In 2010, the estimated incidence was 94 and 264 times higher than nationally reported incidences for individuals aged 50-64 and 65 and older, respectively.

The GSK researchers who led the study, Cristina Masseria, Ph.D, and Girishanthy Krishnarajah, MPH, MBA/MS, utilized data from the IMS private practice database that included more than 80 million claims per year. The commercial laboratory testing database represents approximately 40 percent of respiratory-laboratory testing that took place in the U.S. during the years looked at in the study.

"The CDC, other public health authorities and infectious disease experts have long suspected that pertussis cases in adults go undet
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SOURCE GlaxoSmithKline
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