Navigation Links
Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
Date:9/21/2007

s to Subjects with Severe Renal Impairment"

Cethromycin at 300 mg QD for five days was well tolerated by both subjects with severe renal impairment and with normal renal function. Elevated drug exposure observed for subjects with severe renal impairment suggest that these patients should be monitored when taking cethromycin.

The following poster presentations discussed cethromycin as a potential treatment for CAP, particularly when resistance to other treatments is known:

"Assessment of In Vitro Activity of Cethromycin Against Telithromycin-resistant Strains of Streptococcus Pneumoniae"

All eight clinical Streptococcus pneumoniae isolates were resistant to erythromycin with MICs > 128 micron g/mL and had telithromycin MICs >/= 2 micron g/mL. For six of these isolates, the cethromycin MIC was at least 8-fold lower than the telithromycin MIC, for another isolate the MICs were the same, and for the other the telithromycin MIC was one doubling dilution lower than the cethromycin MIC.

Cethromycin maintained good in vitro potency against a collection of telithromycin-resistant S. pneumoniae isolates. This finding suggests that underlying resistance mechanisms that result in reduced telithromycin susceptibility do not affect cethromycin to the same extent. Therefore, cethromycin continues to represent a reasonable potential therapeutic option for S. pneumoniae of this phenotype.

"Assessment of In Vitro Activity of Cethromycin Against Strains of Streptococcus Pneumoniae"

Cethromycin demonstrated potent in vitro activity against all Streptococcus pneumoniae populations studied, regardless of their resistance phenotype. Based on MIC90 data collected, cethromycin was 2-4 times more potent than telithromycin and 10-12 times more potent than the macrolides studied. These findings demonstrate that cethromycin has the potential to be a potent therapeutic option for the treatment of CAP, even for infections caused by strains resistant to cu
'/>"/>

SOURCE Advanced Life Sciences Holdings, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Molecular Target of Bradmers Neuradiab Further Validated by Independent Findings
3. Phase III Clinical Trial with 4-Month Long-Acting Formulation of Triptorelin: Ipsen Decides Not to Perform Further Administration
4. Further Statistical Analysis of the Recent Phase III trial on Lead Product M6G Shows Additional Benefits
5. New Data on Market-Leading Velcade (Bortezomib) for Injection Further Strengthen Role in Previously Treated Multiple Myeloma
6. Liponex Inc. Reports Further Analysis of CRD5 Phase I/II Clinical Trial Data
7. MIV Therapeutics Announces Pivotal Test Results Further Validating Company Stent Coatings Meet Critical FDA Fatigue Guidelines
8. Managing Preanalytical Processes for Patient Safety
9. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
10. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
11. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 Ambit Biosciences (Nasdaq: AMBI ), a ... unmet needs in oncology, autoimmune and inflammatory disease, today announced ... to be held at The New York Palace Hotel in ... 2014. Alan Fuhrman , Ambit,s CFO, will ... candidate, quizartinib, at 1:10 p.m. ET on Wednesday, September 3, ...
(Date:8/27/2014)... Pa. , Aug. 27, 2014   Auxilium Pharmaceuticals ... integrated specialty biopharmaceutical company, today announced that certain members ... Morgan Stanley Healthcare Conference to be held September 8-10, ... Adrian Adams , Chief Executive Officer and President, is ... its product portfolio at 10:55 a.m. ET on Wednesday, ...
(Date:8/26/2014)... , Aug. 27, 2014 Higher ... insurance are fuelling the demand for medical devices ... rise of medical tourism, the inflow of patients ... The market will continue its steady ascent as ... age-related and non-communicable diseases, compelling significant investments in ...
Breaking Medicine Technology:Ambit Announces Participation At Baird 2014 Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Morgan Stanley Healthcare Conference 3Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 2Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 3Frost & Sullivan: Change in Demographics and Surge in Domestic Manufacturing Drive Asia-Pacific Medical Devices Market 4
(Date:8/27/2014)... University,s Center for Leadership in Disability (CLD) has ... and Child Health Bureau of the Health Resources ... Autism Plan for Georgia, aimed at improving services ... , In preparing for this project, CLD worked ... stakeholders from across Georgia. The resulting plan addresses ...
(Date:8/27/2014)... Los Angeles, CA (PRWEB) August 27, 2014 ... everyone. To do this, Jaha invested in creating the industry’s ... motivation by adding functions that no other apps possess. ... with a tracker that differentiates in three simple steps: locate, ... will launch on Tuesday, Aug 26, 2014 to garner support ...
(Date:8/27/2014)... Ontario (PRWEB) August 27, 2014 Cash ... direct impact on the overall upkeep of the shelter including ... most importantly helping to change the lives of each youth ... a 35 bed emergency shelter for youth ages 16-25. Not ... offers many programs and resources for the youth who come ...
(Date:8/27/2014)... August 27, 2014 The Global and ... study on the current state of the Maleic Anhydride ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 Many ... The reality is that depression has a mortality rate ... with bi-polar disorder is slightly less, though it's offset ... roughly 7%. In order to properly treat and ... and bi-polar, medication must be taken as directed. ...
Breaking Medicine News(10 mins):Health News:Jaha, Inc. The Most Affordable Fitness Band in the Market Released on Kickstarter 2Health News:Cash House a Major Supporter of Horizons for Youth 2Health News:Cash House a Major Supporter of Horizons for Youth 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 2Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 3Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 4Health News:Maleic Anhydride Industry & Isoprene Market Global and China Analysis Now Available at ReportsnReports.com 5Health News:MedicationDiscountCard.com now Makes Brintellix and Mental Illness Medications More Affordable with Discount Cards 2
... rich in meat, cheese and whole milk may be ... and the stomach.The rates of two types of cancer--gastric ... the past 30 years. To investigate potential links between ... cancers and dietary factors, Dr. Susan T. Mayne from ...
... a vacuum device promoted as a breast-enhancer does increase a ... commitment to use the product. The device, known as the ... their breasts for 10 hours a day for 10 weeks ... vacuum device. Skipping even a day adds a week to ...
... amounts of water is very essential for an individual. One ... a day, says a leading physiologist. We've been led to ... a day that's eight glasses// of volume eight ounces ... Heinz Valtin of Dartmouth Medical School, there is no real ...
... techiques. Laser hair removal is a useful remedy for ingrowing ... 'razor bumps' after they shave.// The medical name is pseudofolliculitis ... of a shaved hair grows back into the skin, forming ... painful and it may even leave scars. ,Growing ...
... a new study shows that people with a low potassium ... a stroke. Previous research has suggested that reduced quantities of ... stroke. //The focus on potassium is, perhaps, a new one ... or salt intake low to avoid stroke. But sodium and ...
... is released into the blood after a meal, restrain the ... treating obesity. The reason for feeling full after a meal, ... acts on the brain to produce a feeling of satiety. ... human trial of PYY3-36. ,10 healthy volunteers received ...
Cached Medicine News:Health News:Vacuum device increase breasts 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: