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Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles
Date:6/2/2008

- Results Presented at American Society of Clinical Oncology 44TH Annual

Meeting -

EMERYVILLE, Calif., June 2 /PRNewswire-FirstCall/ -- Bionovo Inc. (Nasdaq: BNVI) today announced results from a second ongoing clinical trial of BZL101, an oral drug candidate, in patients with refractory, metastatic breast cancer. The data, which were presented at the American Society of Clinical Oncology 44th Annual Meeting, showed that BZL101, at higher doses, continues to have a favorable safety and tolerability profile and shows ongoing evidence of clinical activity in women with advanced breast cancer.

"We are encouraged by the positive results of this second study which further underscores BZL101's safety at higher doses and highlights its potential as an effective, novel, oral treatment for the more than 45,000 women who are diagnosed with this late stage breast cancer each year," said lead author, Dr. Alejandra Perez, Director of the Breast Cancer Center at the Memorial Regional Hospital Cancer Institute. "While safety and maximum tolerability are the primary endpoints of the trial, BZL101 also showed early clinical efficacy, including one patient who has been stable for 13 months and shows radiographic evidence of tumor shrinkage."

The study is being conducted by investigators at Duke University, Columbia Presbyterian Medical Center, University of Chicago, University of Texas Southwestern Medical Center, Ohio State University, Montefiore Medical Center, Cancer Research Network and Memorial Regional Cancer Institute in collaboration with scientists at Bionovo. The study is a Phase 1/2 trial, and is currently in the Phase 1 Dose Escalation component, and is expected to progress to the Phase 2 com
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SOURCE Bionovo Inc.
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