Navigation Links
Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms
Date:8/19/2007

NEW YORK, Aug. 14 /PRNewswire-FirstCall/ -- Immtech Pharmaceuticals, Inc. (Amex: IMM) commented today on a recent paper published in Nucleic Acids Research by a group of researchers at the National Cancer Institute on the ability of furamidine to inhibit a key enzyme involved in the DNA repair process (see Note below). Furamidine is the active metabolite (DB75) of Immtech's proprietary, orally bioavailable prodrug, pafuramidine. Of interest is furamidine's potential to inhibit DNA repair in cancerous cells that have been damaged by chemotherapy agents. Furamidine may thus synergistically and selectively enhance the antiproliferative effects of the classes of anticancer agents known as topoisomerase 1 or 2 (Top1, Top2) inhibitors.

This paper highlights a new high-throughput assay for evaluating potential tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and the activity of furamidine as a low micromolar inhibitor of the enzyme. Furamidine was one of the most potent compounds to come from screening a set comprising of 1981 compounds. The screening was part of the NCI-Development Therapeutics Program.

The authors note that functionally, Tdp1 is part of the DNA repair complex that resolves the irreversible Top1-DNA cleavage complexes by catalyzing the hydrolysis of 3'-phosphotyrolsyl bonds. They further suggest that a Tdp1 inhibitor could act synergistically with the Top1 inhibitors. Earlier work implicates Tdp1 in the repair of Top2-mediated DNA damage. Top2 inhibitors represent another class of anticancer agents where a Tdp1 inhibitor may produce a synergistic response.

Eric L. Sorkin, Immtech's Chairman and Chief Executive Officer, stated, "We commend the authors for their efforts. At Immtech, we too con
'/>"/>

SOURCE Immtech Pharmaceuticals, Inc.

Copyright©2007 PR Newswire.

Page: 1 2 3

Related medicine technology :

1. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
2. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
3. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
4. Hypertension Education Foundation Survey Results Announced At American Society For Hypertension Annual Meeting Suggests Improved Control Of High Blood Pressure, But Misconceptions Still Exist
5. The International Myeloma Foundation Reports Positive Shift In Treatment Paradigm For Patients
6. NanoViricides Drugs Found To Be Highly Effective Against Most Recent Strain of the H5N1 Avian Flu Virus
7. Evidence of Nanoparticles Found in Plaque-Filled Arteries
8. Research Supported by Samuel Waxman Cancer Research Foundation Discovers Mode of Action of Arsenic-Based Drugs in Destroying Cancer Cells
9. Cequent Pharmaceuticals Founder to Present tkRNAi Technology at the American Association of Cancer Research Annual Meeting in Los Angeles
10. The International Myeloma Foundation Says New Clinical Trial Results Could Improve Survival While Reducing Side Effects For Many Patients
11. The American Liver Foundation Urges Cautious Optimism about CDC Report on Declining Acute Hepatitis Infection Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... --  West Pharmaceutical Services, Inc. (NYSE: ... injectable drug administration, announced today it plans to expand ... in Waterford, Ireland . The new ... and other high-value packaging components, in order to meet ... this new site could bring approximately 150 new jobs ...
(Date:10/2/2014)... BOSTON , Oct. 1, 2014   Intarcia ... two of its four phase 3 clinical trials for ... through a matchstick-sized, subcutaneous osmotic mini-pump). The first trial, ... that tested the efficacy and safety of ITCA 650 ... study demonstrated ITCA 650 to be significantly superior to ...
(Date:10/1/2014)... Ohio , Oct. 1, 2014 /PRNewswire/ ... shareholders is now available. Interested parties can learn ... how Cardinal Health is supporting the health ... http://cardinalhealth.com/annualreport . Photo- ... to summary financials and the chief executive ...
Breaking Medicine Technology:West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 2West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 3West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 4West Announces Plans for a New Pharmaceutical Component Manufacturing Plant in Ireland 5Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 2Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 3Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 4Intarcia Announces Two Positive Phase 3 Trials for ITCA 650 in Type 2 Diabetes: FREEDOM-1 and FREEDOM-1 High Baseline (HBL) Study Results 5Cardinal Health 2014 Digital Report to Shareholders Now Available 2
... -- Global Information, Inc. is excited to announce remaining ... scheduled for Boston, MA in the Spring of 2012. ... Drug Design Conference June 6 - ... to arrive at its current mainstream position in medicinal chemistry, ...
... developer of Healthcare Technology Networks ("HTN") designed to improve ... announces the launch of its proprietary Opioid Management Program ... United States Bone & Joint Decade , from ... from musculoskeletal disease filled 1.6 billion prescriptions. While 18.6 ...
Cached Medicine Technology:Boston to Host 3 Major Annual Drug Discovery Conferences, Early Bird Expiring April 27 2Boston to Host 3 Major Annual Drug Discovery Conferences, Early Bird Expiring April 27 3Med-Tek Launches the First Evidenced Based Opioid Management Program (OMP) 2
(Date:10/2/2014)... (PRWEB) October 02, 2014 BamboofloorChina.com is ... its products have won great appreciation from the global ... is working hard to make more excellent items. All ... ready to help all clients. , The company ... panels to its website. Furthermore, the company’s marketing ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... personality style and prolonged stress may have a heightened ... Tracking 800 women over nearly four decades, Swedish scientists ... moody -- which they defined as neurotic -- and ... Alzheimer,s compared to women scoring lowest in these traits. ...
(Date:10/2/2014)... may interact with stress to trigger heart disease in some ... in about 13 percent of people, but only in those ... their heart disease risk through simple measures such as ... researchers said. The study authors analyzed genetic data from ... in the EBF1 gene and higher levels of central obesity, ...
(Date:10/2/2014)... Steven Reinberg HealthDay Reporter ... a major highway may raise your risk for high blood ... postmenopausal women, those who lived within 109 yards of a ... high blood pressure than women living at least half a ... study highlight the importance of our physical environment on our ...
(Date:10/2/2014)... By Amy Norton HealthDay ... adults who have trouble smelling the roses -- literally -- may ... new research suggests. In a study of over 3,000 older ... as rose, orange and peppermint were more than three times as ... a sharp sense of smell. In fact, anosmia -- the ...
Breaking Medicine News(10 mins):Health News:High Quality Bamboo Panels Online At BamboofloorChina.com 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 2Health News:Jealous, Moody Women May Face Higher Alzheimer's Risk, Study Says 3Health News:Genes May Make Some More Prone to Heart Disease When Under Stress 2Health News:Living Near a Highway May Be Bad for Your Blood Pressure 2Health News:Living Near a Highway May Be Bad for Your Blood Pressure 3Health News:Could a Fading Sense of Smell Point to Earlier Death? 2Health News:Could a Fading Sense of Smell Point to Earlier Death? 3
... Sept. 2 A survey of emergency medical services (EMS) ... of workplace safety cultureproviding a tool that might point to ... of Pittsburgh School of Medicine. The study ... Prehospital Emergency Care and now available online, analyzed survey ...
... Melissa Lee Phillips HealthDay Reporter , WEDNESDAY, Sept. ... mentally stimulating activities have pros and cons when it comes ... prior research, the study finds that such mental activity may ... But folks who loved these pursuits actually displayed a ...
... Sept. 1 (HealthDay News) -- A new study is linking ... non-fatal heart attacks and stroke, although taking the drug did not ... history of heart problems. The finding is stirring mixed reactions ... was funded by Meridia,s maker, Abbott, the findings are generally in ...
... September issue of the Journal of the American Geriatrics ... have a greater risk for dementia than Veterans without PTSD, ... Exposure to life threatening events, like war, can cause PTSD, ... symptoms such as avoiding things or people that remind a ...
... Engineering at Harvard and from Boston University have discovered ... microscopic forms of lifebacteria. Their findings appear in ... studying the development of antibiotic-resistant strains of bacteria, the ... doses of antibiotics are those in which a few ...
... Lee Phillips HealthDay Reporter , WEDNESDAY, Sept. ... inflammation in those with lupus, but the anti-clotting drug ... disease, a new study suggests. Platelets, which are ... clotting, are suspected to be involved in lupus, explained ...
Cached Medicine News:Health News:Safety cultures in EMS agencies vary widely, Pitt study finds 2Health News:Mental 'Exercise' May Only Hide Signs of Alzheimer's 2Health News:Mental 'Exercise' May Only Hide Signs of Alzheimer's 3Health News:Diet Pill Meridia Ups Heart Attack Risk: Study 2Health News:Diet Pill Meridia Ups Heart Attack Risk: Study 3Health News:Pivotal study finds link between PTSD and dementia 2Health News:New research finds evidence of charitable behavior in bacteria 2Health News:Overactive Blood Platelets May Play Role in Lupus 2
The CH 2000 Cardiac Diagnostic system is a fully featured stress testing system that can include Microvolt T-Wave Alternans (MTWA) testing capability as an add-on feature. , ,Interfaces with Tra...
... The Volk G-1 trabeculum provides the highest ... Perfect for viewing and treating the trabecular meshwork. ... of the anterior chamber angle while the central ... view the posterior pole for signs of glaucoma ...
... The AFX (Air Fluid eXchange) ... lens designed for use in ... to its use as a ... the low profile and sutureless ...
... The 45° Prism ... fundus pathologies and are ... detachments (PDR, BRVO etc.) ... They can be used ...
Medicine Products: