Navigation Links
Furamidine Found to Inhibit a Key Enzyme Involved in Cancer Cell DNA Repair Mechanisms
Date:8/19/2007

NEW YORK, Aug. 14 /PRNewswire-FirstCall/ -- Immtech Pharmaceuticals, Inc. (Amex: IMM) commented today on a recent paper published in Nucleic Acids Research by a group of researchers at the National Cancer Institute on the ability of furamidine to inhibit a key enzyme involved in the DNA repair process (see Note below). Furamidine is the active metabolite (DB75) of Immtech's proprietary, orally bioavailable prodrug, pafuramidine. Of interest is furamidine's potential to inhibit DNA repair in cancerous cells that have been damaged by chemotherapy agents. Furamidine may thus synergistically and selectively enhance the antiproliferative effects of the classes of anticancer agents known as topoisomerase 1 or 2 (Top1, Top2) inhibitors.

This paper highlights a new high-throughput assay for evaluating potential tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and the activity of furamidine as a low micromolar inhibitor of the enzyme. Furamidine was one of the most potent compounds to come from screening a set comprising of 1981 compounds. The screening was part of the NCI-Development Therapeutics Program.

The authors note that functionally, Tdp1 is part of the DNA repair complex that resolves the irreversible Top1-DNA cleavage complexes by catalyzing the hydrolysis of 3'-phosphotyrolsyl bonds. They further suggest that a Tdp1 inhibitor could act synergistically with the Top1 inhibitors. Earlier work implicates Tdp1 in the repair of Top2-mediated DNA damage. Top2 inhibitors represent another class of anticancer agents where a Tdp1 inhibitor may produce a synergistic response.

Eric L. Sorkin, Immtech's Chairman and Chief Executive Officer, stated, "We commend the authors for their efforts. At Immtech, we too con
'/>"/>

SOURCE Immtech Pharmaceuticals, Inc.

Copyright©2007 PR Newswire.

Page: 1 2 3

Related medicine technology :

1. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
2. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
3. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
4. Hypertension Education Foundation Survey Results Announced At American Society For Hypertension Annual Meeting Suggests Improved Control Of High Blood Pressure, But Misconceptions Still Exist
5. The International Myeloma Foundation Reports Positive Shift In Treatment Paradigm For Patients
6. NanoViricides Drugs Found To Be Highly Effective Against Most Recent Strain of the H5N1 Avian Flu Virus
7. Evidence of Nanoparticles Found in Plaque-Filled Arteries
8. Research Supported by Samuel Waxman Cancer Research Foundation Discovers Mode of Action of Arsenic-Based Drugs in Destroying Cancer Cells
9. Cequent Pharmaceuticals Founder to Present tkRNAi Technology at the American Association of Cancer Research Annual Meeting in Los Angeles
10. The International Myeloma Foundation Says New Clinical Trial Results Could Improve Survival While Reducing Side Effects For Many Patients
11. The American Liver Foundation Urges Cautious Optimism about CDC Report on Declining Acute Hepatitis Infection Rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 2015   Precision Image Analysis (PIA) is ... advances in cardiovascular imaging and post-processing. Scott D. ... Society for Cardiovascular Magnetic Resonance (SCMR) will be ... patient management by providing broader access to Cardiac MRI ... to better understand appropriate use of CMR, the strengths ...
(Date:4/20/2015)... April 20, 2015  Sigma-Aldrich Corporation (Nasdaq: ... (CR) Magazine,s list of the 100 Best Corporate ... corporate responsibility performance.  Sigma-Aldrich ranked fifth, its highest ... the list. "We are honored to ... efforts and we are extremely pleased with our ...
(Date:4/20/2015)... N.J. , April 20, 2015  Johnson & ... of its Pharmaceutical business for the investment community beginning ... 2015 at the Hyatt Regency Hotel in ... approximately 3:00 p.m. Paul Stoffels , ... Joaquin Duato , Worldwide Chairman, Pharmaceuticals will host ...
Breaking Medicine Technology:Educational Webinar Teaches Improved Patient Management Through Broader Access to Cardiac MRI 2Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2
... Actavis, an international generic pharmaceutical company, today announced that ... CII, an authorized generic of KADIAN®*. Actavis ... in-depth expertise in the development and manufacturing of complex ... grown 50% in the last 5 years to approximately ...
... Lotus Pharmaceuticals, Inc. (OTCBB: LTUS) ("Lotus" or the "Company"), ... in the People,s Republic of China ("PRC"), today announced its ... 2011. Summary financial data is provided below: ... Highlights Revenues for the third quarter of ...
Cached Medicine Technology:Actavis Launches Generic KADIAN® Capsules in the U.S. 2Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 2Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 3Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 4Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 5Lotus Pharmaceuticals Announces Third Quarter 2011 Financial Results 6
(Date:4/21/2015)... 21, 2015 eMindful, the ... added Michael Gallagher as senior vice president of sales. ... management and leadership roles with major health insurance carriers, ... Most recently he managed national accounts for The Vitality ... he was consistently a top producer, sales manager and ...
(Date:4/21/2015)... DIAMOND BAR, CALIF. (PRWEB) April 21, 2015 ... a leading provider of enterprise Time and Attendance ... the 33rd Annual Congress from the American Payroll ... and Partner Conference. , The APA has been ... year’s Congress brings workshops, networking opportunities, and recertification ...
(Date:4/21/2015)... Nashville, Tenn. – Radsource, a ... Picture Archiving and Communication Systems (PACS), has expanded ... in the first quarter of 2015. , Kentucky ... TN) and Lowcountry Orthopaedics & Sports Medicine (Charleston, ... archiving services. Mt. San Rafael Hospital (Trinidad, CO) ...
(Date:4/21/2015)... 2015 Bulk food-grade transportation services ... of 5, indicating generally favorable purchasing conditions for buyers. ... to entry and the fact that most bulk food ... distances,” says IBISWorld research analyst Hayden Shipp. “As such, ... serving local and regional markets.” Suppliers include Ruan Transportation ...
(Date:4/21/2015)... Angeles, CA (PRWEB) April 21, 2015 Lifeguard ... Spider Straps offerings. All products are listed on the Lifeguard ... a favorite of EMS workers who want a quality and ... Master spokesperson, “Our Spider Straps and color Spider Straps are ... easy to use and made of sturdy, heavy nylon” , ...
Breaking Medicine News(10 mins):Health News:eMindful Continues to Expand Executive Leadership Team With Employee Benefits Sales Executive Michael Gallagher 2Health News:NOVAtime Participates in 2015 APA Congress and NetSuite SuiteWorld Conferences in May 2Health News:NOVAtime Participates in 2015 APA Congress and NetSuite SuiteWorld Conferences in May 3Health News:Radsource Adds 4 ProtonPACS Clients in 1st Quarter 2Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Bulk Food-Grade Transportation Services Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 2Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 3Health News:New Spider Straps for Spine Boards are Introduced for Easy, Fast, and Convenient Use 4
... set by drug traffickers, a new breed of tobacco ... be affected soon, a top official //of the World ... international drug cartels have some links with terrorists but ... with terrorist outfits. Security agencies in the European Union ...
... of men in western cultures are affected by Obstructive ... OSA experience more harmful //psychological symptoms than people with ... of Forensic Sciences. ,Sex offenders with ... Airway Pressure(CPAP), whereby compressed air is applied into the ...
... disease that is preventable and curable, yet every 30 seconds ... posed one of the biggest challenges //to healthcare experts and ... a punch through an innocuous looking mite. It is apt ... proud much before the unique selling 'Made in China' tag, ...
... called as 'Black Disease' as commented by Phill Wilson, executive ... is because of the growing AIDS population among the blacks, ... across the country. African-Americans comprise 13% of the total population ... prone to disease 10 times more than the whites. ...
... research suggests that testosterone replacement therapy for men with ... the prostate gland, contrary to some reports that this ... the November 15 issue of JAMA, a theme issue ... of the Urological Sciences Research Foundation and University of ...
... who received a combination therapy were more likely to report ... according to a study in the November 15 issue of ... ,Steven A. Kaplan, M.D., of Weill Cornell Medical College, New ... JAMA media briefing on men's health in New York. ...
Cached Medicine News:Health News:Tobacco Smugglers are Helping Terrorists: WHO 2Health News:Malaria: The Invincible Might of a Parasite, Nestled in a 'Mite' 2Health News:Malaria: The Invincible Might of a Parasite, Nestled in a 'Mite' 3Health News:Testosterone Replacement Therapy Appears Safe for Prostate 2Health News:Combination Therapy More Effective for Treating Lower Urinary Tract Symptoms 2
3.5v Ophthalmic Diagnostic Set with AutoStep Coaxial Ophthalmoscope, Spot Retinoscope, Rechargeable Handle, and Soft Case. High-quality eyecare from the preferred name in diagnostic instruments....
3.5v Ophthalmic Diagnostic Set with Diagnostic Ophthalmoscope, Spot Retinoscope, Rechargeable Handle, and Soft Case. High-quality eyecare from the preferred name in diagnostic instruments....
Our 3.5v Streak or Spot Retinoscope Sets feature instruments with the brightest light output in the industry, reliable handles, and convenient cases....
... The Binocular Indirect Ophthalmoscope Power Source ... superior line of ophthalmic instruments. The versatile ... a desk, wall, or on the side ... place it. The portable power pack provides ...
Medicine Products: