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Frost & Sullivan Recognizes QRxPharma for Innovative Pain Relief Product MoxDuo
Date:8/17/2010

otected Dual-Opioid® Technology that allows morphine and oxycodone to work synergistically resulting in a more potent pain reliever and a 25 to 75 percent decrease in moderate-severe adverse side effects."

Recent public scrutiny over safety concerns of Vicodin® (hydrocodone and acetaminophen) and Percocet® (oxycodone and acetaminophen), the leading opioids for the treatment of acute pain in terms of number of prescriptions, has seen the FDA's Drug Safety and Risk Management Advisory Committee recommend a ban on two combination drugs of this type. The recommendation was due to the large incidents of liver damage and death from high doses of acetaminophen. Moreover, as opioids are associated with tolerance, patients taking these medications over a long period of time typically require higher doses to achieve the same effect.

In contrast, MoxDuo IR is more effective in pain relief and has a more attractive side effect profile than that of competing products. As part of its comprehensive Phase III clinical trial program, QRxPharma compared equianalgesic doses of MoxDuo IR with morphine, oxycodone or Percocet® in patients with moderate to severe pain following bunionectomy surgery and/or total knee replacement surgery. Patients taking MoxDuo IR reported fewer occurrences of hypotension, constipation, vomiting, and moderate to severe nausea than patients receiving equal analgesic doses of these traditional opioids.  In a pivotal Phase III clinical trial comparing the safety and efficacy of MoxDuo IR with its individual components, oxycodone and morphine, MoxDuo IR at twice the dose of each its morphine or oxycodone components was found to provide better efficacy.

In addition to MoxDuo IR, QRxPharma is also developing a controlled-release (CR) and an intravenous (IV) formulation of MoxDuo.  MoxDuo CR will provide at least 12 hours of pain relief for patients who need around-the-clock pain relief for lower back pain or canc
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