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Frost & Sullivan Recognizes KAER's Game-Changing Innovating Aerosol Drug Delivery Methods for High-Dose Respiratory Disease Therapeutics
Date:2/26/2013

MOUNTAIN VIEW, Calif., Feb. 26, 2013 /PRNewswire/ -- Based on its recent analysis of the aerosol drug delivery technology market, Frost & Sullivan recognizes KAER Biotherapeutics with the 2012 North America Frost & Sullivan Award for Technology Innovation for SUPRAER™. KAER has developed and patented the SUPRAER™ technology, which is a new platform for aerosolizing biologics and delivering them to the lungs without the use of any excipients. As this technology completely eliminates the safety issues normally associated with excipients, it saves costs on animal trials.

The SUPRAER™ technology generates a large aqueous aerosol of the biologic, which is then rapidly dried, concentrated, and delivered as a solid-phase respirable aerosol, pure in constituency. The creation of liquid droplets, which shrink to the desired respirable particle size range for deep lung administration when dried, requires less shear-inducing energy than present jet nebulizers.

"The technology consists of a proprietary low-shear spray nozzle, in combination with an innovative particle-drying chamber and a low-resistance particle concentrator," said Frost & Sullivan Research Analyst Darshana De . "The combination helps generate high concentrations of hollow particles in an aerosol-based drug delivery system. These hollow particles can carry a larger mass than solid particles having the same aerodynamic diameter."

The SUPRAER™ technology can deliver drugs directly and effectively to the lungs with an 80 percent reduction in dosage compared to intravenous administration. Consequently, it prevents the occurrence of harmful systemic side effects.

SUPRAER™ also has the ability to deliver respirable aerosols generated from relatively viscous solutions of large molecules. The aerosol generation nozzle aerosolizes solutions of large active molecules, without degrading the biol
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