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Frost & Sullivan Lauds IncellDx for Developing a Novel, Non-invasive Method for Cervical Cancer Testing
Date:9/11/2012

When HPV infections progress towards cervical cancer they integrate into the patient's host genome which causes HPV E6, E7 mRNA to be over-expressed. Frost & Sullivan's competitive benchmarking reveals that IncellDx's HPV OncoTect® methodology has a unique and powerful approach to the detection and quantification of E6 and E7 mRNA inside each collected cervical cell. 

"Unlike other molecular diagnostic technologies that are limited to detecting high-risk HPV infections off of genomic material extracted from lysed cervical cells, IncellDx's patented technology is able to keep the target cervical cells intact and thereby quantify the actual E6, E7 mRNA overexpression in each and every cell," observes Brice. "Studies have shown that the HPV OncoTect® technology is much more predictive of actionable cervical disease than screening for high-risk HPV."

In the near future Frost & Sullivan expects OncoTect 3DxTM to transform the traditional Pap based cytopathology laboratory. With the addition of image cytometry, 3DxTM adds the morphological analysis routinely done in a Pap test to the molecular analysis from the OncoTect® method. Once commercially available this technology will enable laboratories to retire their microscopes for cervical cancer screening and completely digitize their cytopathology testing.

"With as many as 60 million Pap tests analyzed in the U.S. annually, IncellDx's technology could supplant an entire $2 billion Pap screening industry," observes Brice. "And in countries such as China, where the required infrastructure for widespread Pap screening does not even exist, OncoTect 3DxTM could easily become the primary approach to cervical cancer screening."

Looking forward, IncellDx can leverage its burgeoning relationships with many of the world's largest reference laboratories to ensure continued excellence in strategy and opera
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