Navigation Links
Fred Hutchinson Cancer Research Center Partners With GlaxoSmithKline to Develop Muscular Dystrophy Therapeutics
Date:12/10/2012

SEATTLE, Dec. 10, 2012 /PRNewswire/ -- Fred Hutchinson Cancer Research Center and GlaxoSmithKline PLC (GSK) today announced a partnership to develop therapeutics to treat an inherited form of muscular dystrophy.  

The goal of the new agreement is to develop a small-molecule-based medicine to potentially reverse facioscapulohumeral muscular dystrophy, or FSHD, by inhibiting the activity of a protein that is incorrectly expressed by the DUX4 gene in people with the disease. The protein activity is what damages muscle cells and leads to progressive muscle weakness and atrophy in FSHD patients.

The genetic and disease mechanisms of FSHD were discovered by an international team of scientists led by Stephen Tapscott, M.D., Ph.D., a member of the Fred Hutch Human Biology Division, in a series of studies published between 2010 and early 2012. Tapscott will lead the Fred Hutch work in the GSK collaboration.

The team's discoveries also have implications for developing cancer immunotherapies because researchers also discovered that DUX4 regulates cancer/testis antigens. Cancer/testis antigens are encoded by genes that are normally expressed only in the human germ line but are also abnormally expressed in various tumor types, including melanoma and carcinomas of the bladder, lung and liver. This knowledge will give researchers a way to manipulate the expression of cancer/testis antigens, potentially opening the opportunity to use these antigens in a cancer vaccine.

The partnership with GSK is a first of its kind for Fred Hutch, which is also the first U.S.-based institution to sign on with GSK's "Discovery Partnership with Academia" (DPAc) program. GSK launched the program last year to combine the insight and creativity of the academic world with GSK's drug-discovery expertise to turn inno
'/>"/>

SOURCE Fred Hutchinson Cancer Research Center
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Actinium Pharmaceuticals Announces The Addition of The Fred Hutchinson Cancer Research Center To Actiniums Multicenter Clinical Trial For Patients With Acute Myeloid Leukemia
2. Artemis Diagnostics awarded two grants from Technology Strategy Board to develop cancer imaging technology
3. Quebec Clinic Launches Canadian Use of Elektas Agility Beam-Shaping Innovation for Radiation Therapy of Cancer
4. German Cancer Research Center Selects Contur ELN from Accelrys
5. MetaStat Announces Presentations at the 2012 San Antonio Breast Cancer Symposium
6. Prostate Cancer Study: Most Patients Report Satisfaction After Robotic Surgery
7. Eisai Oncology to Present New Research on Eribulin at 35th Annual San Antonio Breast Cancer Symposium
8. Gynecologic Oncology Publishes New Clinical Study Showing Positive Performance of OVA1, Vermillions Ovarian Cancer Test
9. Trovagene to Introduce First Urine-Based Molecular Diagnostic Test for Transrenal Cancer Mutation Monitoring
10. Novartis highlights key data in patients with hematologic diseases and breast cancer with more than 140 abstracts at ASH and SABCS
11. The Oncology Nurse Community To Host Live Webinar On Cancer Pain Management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014 /PRNewswire-iReach/ -- VAPETEK™, ... a vegetable-glycol solution for use in portable vaporizers, ... the active ingredients in cannabis, cannabidiol offers consumers ... vaporizer devices, and other vaporizer technology. ... Cannabis naturally contains 483 different compounds which are ...
(Date:7/11/2014)... , July 11, 2014 Patient ... marketing and, consequently, organizations are turning to an ... As part of this evolving approach ... to educate, communicate and engage patients throughout their ... to patient empowerment. By mapping the patient journey ...
(Date:7/11/2014)... , July 11, 2014 The consumer ... evolving across industry sectors to better identify winning ... ways to engage with and understand consumers, as ... and make critical purchasing decisions. ... Practices, LLC, one area where organizations can observe ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
... & Johnson (NYSE: JNJ ) will host a ... on Tuesday, October 18, 2011, to review third-quarter results.  Dominic ... Mehrotra, Vice President, Investor Relations, will host the call. ... by visiting the Company,s website at www.investor.jnj.com . ...
... REDWOOD CITY, Calif., Oct. 11, 2011 Codexis, Inc. ... Antonio Clement has been named Director, Latin America. He ... with responsibility for managing Codexis, expanding role in Latin ... Technology Officer and SVP, Process Development and Manufacturing. ...
Cached Medicine Technology:Codexis Names Veteran Chemical Executive to Lead Codexis do Brasil 2Codexis Names Veteran Chemical Executive to Lead Codexis do Brasil 3
(Date:7/11/2014)... (PRWEB) July 12, 2014 Recently, MagicQuinceaneraDresses.com, ... released its new collection of 2014 Quinceanera dresses ... those who want to look fashionable without paying a ... discounted prices, up to 57% off. , The company’s ... ladies to get amazing special occasion outfits. In addition ...
(Date:7/11/2014)... 2014 Recently, DressyQuinceanera.com, a well-known wedding ... Dama dresses to its online category. Furthermore, the ... at deeply discounted rates, up to 62% off. , ... equally excellent in terms of quality and style. All ... discounts are also offered for the company’s other items: ...
(Date:7/11/2014)... 2014 The American Association of Poison ... centers are commending Senator Bill Nelson (D-FL) for his ... 2014 on July 10, 2014. Along with fellow Senate ... Commission (CPSC) to enact rules requiring safer, child-resistant packaging ... , Senate co-sponsors of the bill include: Sen. Richard ...
(Date:7/11/2014)... According to new report "C4ISR Market ... to register a CAGR of 2.28% to reach ... data tables and 76 figures spread through 185 ... http://www.marketsandmarkets.com/Market-Reports/c4isr-market-1315.html , Early buyers will receive 10% ... The report provides market analysis of the global ...
(Date:7/11/2014)... 2014 Ticket Down reports that tickets to ... 3rd place World Cup Match between Brazil and Netherlands ... take place on Saturday, July 12th at Estadio Nacional de ... will take place on Sunday, July 13th at Estadio Jornalista ... tickets for the 2014 World Cup are guaranteed to be ...
Breaking Medicine News(10 mins):Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:DressyQuinceanera.com: Beautiful Quinceanera Dama Dresses At Low Prices 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... 8 The Integrated,Healthcare Association (IHA) welcomes Leah ... annual National Pay for Performance Summit at the,Beverly ... is the,leading forum on pay for performance to ... Group has made outstanding contributions toward the,improvement of ...
... - code situations in hospital parlance - easily expose common ... for children and also set up powerful incentives to ... a study from the Johns Hopkins Childrens Center. , ... and published in the January issue of Pediatrics, found sometimes ...
... GOVERNOR AT RECEPTION 5:30 PM WED., FEB. 13 AT ... CHAMBER, WVAADC, LEGISLATIVE LEADERS, AND CRC HEALTH GROUP ... 8 Four-Star General,Barry McCaffrey (ret.), the former White ... policy expert in the national media, will,spearhead a Feb. ...
... Amscot Financial, a leading,provider of convenient, consumer-oriented ... fun "the Amscot way" at its open house ... at 3260 Vineland Road in Kissimmee. Amscot,will present ... of the,Juvenile Diabetes Research Foundation, which underwrites efforts ...
... woman who collapsed and died shortly after arriving for her ... first reported death to be reported nationally from acute asthma ... by a Michigan State University physician, published in the February ... outlines circumstances under which the woman died, but also raises ...
... Chefs Help Raise Awareness and $50,000 for UNICEF, ... Burke, Paul,Prudhomme and Michael Symon are among eleven ... Idaho Potato Commission,s "Recipes for Relief",on-line program. The ... the United,Nation,s declaration of 2008 as the International ...
Cached Medicine News:Health News:Integrated Healthcare Association Welcomes Leah Binder, New CEO of Leapfrog Group to National Pay for Performance Summit 2Health News:Mock CPR 'codes' expose weaknesses in hospital emergency response for children 2Health News:4-Star Gen. Barry McCaffrey, Former U.S. Drug Czar, and Dr. Barry Karlin, Nation's #1 Drug Treatment Provider, to Spearhead Drug Treatment WVA Advocacy Day Feb 13-14; 142,000 Need, Don't Get Treatment in State 2Health News:Amscot Financial Contributes to the Juvenile Diabetes Research Foundation, Supporting Upcoming 'Walk for a Cure' 2Health News:Case links death to environmental tobacco smoke 2Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 2Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 3Health News:Idaho Potato Commission Launches 'Recipes for Relief' in Celebration of the International Year of the Potato 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: