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Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

. SPECT measures regional cerebral blood flow (rCBF) which is closely related to brain cell activity. The study showed that treatment with MTC at the 60mg dose eliminated the rCBF decline that was seen in control subjects. The effect was greatest in brain regions that had the most severe tau aggregation pathology, namely the hippocampus and the entorhinal cortex, which are regions affected early and most severely in Alzheimer's.

"This is the first instance of a disease-modifying Alzheimer's therapy that has attained its primary, pre-specified cognitive efficacy target in a clinical trial," said Wischik. "This trial therefore provides the first clinical trial evidence that an Alzheimer's therapy aimed at blocking tau aggregation may be a viable disease-modifying treatment. We now need to confirm this in a larger Phase III trial."

"Our results appear to meet the draft EMEA clinical guidelines for disease-modifying therapy, supported by SPECT and PET evidence of efficacy in brain regions heavily affected by tau pathology," Wischik added.

Proof of Concept Clinical Trial of Souvenaid(TM): A Medical Nutrition Approach to Mild Alzheimer's

People with Alzheimer's exhibit a significant loss of brain synapses, and this loss correlates with the loss of cognitive function. Pre-clinical research using a technique invented by Massachusetts Institute of Technology (MIT) has shown that specific combinations of nutrients can increase synapse formation. Now a double-blind, controlled study with Souvenaid(TM), including these nutrients, has shown it may help patients with mild Alzheimer's Disease.

Souvenaid(TM), developed by Danone Research - Centre for Specialised Nutrition, is designed to improve synapse formation and synaptic transmission via the synergistic action of a combination of nutrients (specifically, it contains uridine monophosphate, choline, the omega-3 fatty acids (EPA, DHA), phospholipids, B vitamins and antioxidants). Pre-clinical re
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SOURCE Alzheimer's Association
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