Navigation Links
Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

s adverse events reported with PBT2.

"These results indicate that PBT2 is having an impact on the underlying biology of Alzheimer's, which is very exciting," Cummings said. "This is a critical proof of concept, and the safety and efficacy demonstrated by PBT2 in this study warrant evaluation in larger scale clinical trials in Alzheimer's."

A Phase IIb trial of a Tau Aggregation Inhibitor Therapy

As an alternative to anti-amyloid therapies for Alzheimer's, researchers continue to examine a variety of treatments and targets with the potential to curb the disease. This includes presenting data supporting the viability of therapies targeting tau protein and its aggregation into the "tangles" originally discovered by Alois Alzheimer.

Previous research has shown that the buildup of brain lesions known as neurofibrillary tangles, which are composed of a short fragment of a protein called tau, is correlated with increasing levels of dementia symptoms. And, these tangles first appear in the brain long before symptoms of the disease become clinically apparent. Methylthioninium chloride (MTC, or brand name rember(TM)) has been shown in the test tube to dissolve tau tangle filaments and prevent aggregation of tau into tangles. MTC has also been shown to block the toxic effects of aggregated tau in cells. In animal models, MTC has demonstrated cognitive and behavioral benefits in line with reduced tau pathology.

In research reported at ICAD 2008, Claude M. Wischik, Professor in Mental Health, University of Aberdeen, United Kingdom and Chairman, TauRx Therapeutics, Singapore, and colleagues conducted a 24-week, double-blind, randomized, dose-ranging, parallel design trial of MTC monotherapy in 321 people with Alzheimer's at 17 centers in the United Kingdom and Singapore, followed by a 60-week, blinded, active treatment extension. The control group received placebo for the initial 24 weeks and then a minimal efficacy dose subsequently. The primar
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Echo Therapeutics Announces Positive Results of a Clinical Study of its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
2. CuraGen Reports Second Quarter 2008 Financial Results and Clinical Progress of CR011-vcMMAE
3. Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results and Provide a Clinical Program Update on August 7, 2008
4. Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation
5. Controversy About Lack of Placebo Group Decline in Alzheimers Clinical Trials
6. Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit
7. Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer
8. Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine)
9. Pharmatech, Inc. Contracts for Five New Just-in-Time Clinical Trials
10. Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
11. Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces that ... catalogue: Baby Food Eastern Europe 2014 ... Food Eastern Europe 2014" is a new report by ... in Eastern Europe , key segments, ... This report also examines trends which are currently affecting ...
(Date:8/27/2014)... , Aug. 27, 2014 /PRNewswire/ ... market research report is available in ... Guidebook for Application and Approval of ... to Practices (2014 Edition) ... Now, Chinese regulations on ...
(Date:8/27/2014)... N.J. and NINGBO, China ... and the Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today ... the development of generic pharmaceuticals, primarily targeting ... of the agreement, Amerigen and Menovo will jointly develop ... United States . Menovo will be responsible for ...
Breaking Medicine Technology:Baby Food Eastern Europe 2014 2Baby Food Eastern Europe 2014 3Baby Food Eastern Europe 2014 4Baby Food Eastern Europe 2014 5Baby Food Eastern Europe 2014 6Baby Food Eastern Europe 2014 7Baby Food Eastern Europe 2014 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2
... EAST RUTHERFORD, N.J., Nov. 1, 2010 Cambrex Corporation ... 2010 financial results will be released on Wednesday, November ... The Company will host a conference call to discuss ... Conference CallWhen: , Thursday, November 4, 2010 at ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... November 8, 2010, after the U.S. financial markets close. ... Monday, November 8, 2010 at 5:00 p.m. Eastern Standard Time ...  A live webcast of the call will be available online ...
Cached Medicine Technology:Anadys Pharmaceuticals to Report Third Quarter 2010 Financial Results 2
(Date:8/27/2014)... New Jersey’s own Morgan Hoffmann turned ... Club during The Barclays – and thanks to finishing ... tournament’s four rounds, stepped his way into raising another ... Shield of New Jersey (Horizon BCBNSNJ) Walking Challenge. , ... playing before family and friends at the Paramus course, ...
(Date:8/27/2014)... in the use of hormone therapy has spawned a ... in silence with hot flashes, according to a study ... , In the study published in the Aug. ... the team found that moderate to severe hot flashes ... treated in most women. Women with VMS experience more ...
(Date:8/27/2014)... News) -- Young adults who struggled with depression in ... researchers are reporting. The findings might improve understanding ... predict, prevent and treat the illness, according to the ... conducted brain scans on 30 volunteers, ages 18 to ... a control group of 23 young adults who never ...
(Date:8/27/2014)... CA (PRWEB) August 27, 2014 Ticket ... vs. Chile tickets at Levi’s Stadium in Santa Clara. ... in Santa Clara, California just opened in July and will ... when Mexico takes on Chile. These are two of the ... the 2014 World Cup and will look to continue their ...
(Date:8/27/2014)... 27, 2014 Michigan Head & Neck Institute ... of a local elementary school by ensuring they have everything ... has year-round attendance, and Michigan Head & Neck Institute wants ... new school year. , "There are a lot of military ... great way to give back to our community," said Lauren ...
Breaking Medicine News(10 mins):Health News:Morgan Hoffmann, PGA TOUR Pro & Wyckoff Native, golfs and walks his way to top 10 finish at The Barclays while raising additional $7,500 for charity 2Health News:The high cost of hot flashes: Millions in lost wages preventable 2Health News:Study: Young Adults Who Had Depression Have 'Hyper-Connected' Brain Networks 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 2Health News:Mexico vs. Chile Tickets at Levi’s Stadium: Ticket Down Cuts Ticket Prices for Inaugural Soccer Match between Chile and Mexico in Santa Clara 3Health News:Michigan Head & Neck Institute is Conducting Their 2nd Annual School Supplies Drive at Their Facility to Benefit Local Year-Round Elementary School Students 2
... April: The first-proof-of-concept for a DNA-based therapeutic vaccination against ... the Annual Meeting of the European Association for the ... the first clinical trial of a therapeutic vaccination using ... effects were shown in patients with hepatitis C (HCV). ...
... Maintains WBENC Certification. , ... Washington, ... of foreign language interpretation, translation and proficiency testing services to ... its renewed certification as a Women’s Business Enterprise (WBE) through ...
... and veterinary neurologist and neurosurgeon Dr. Anne Chauvet is offering a free ... with the right information and supplies. , ... Sarasota, Fla. (PRWEB) -- ... Veterinary Neuro Services to help owners aid their pets in an emergency., ...
... University School of Medicine (BUSM) have found that among preteens, ... motivate them to improve sun protection practices and limit number ... of the Journal of the Dermatology Nurses, Association . ... our society, and overexposure to UV light in childhood is ...
... Continues to Defend Intellectual Property Rights for EvistaINDIANAPOLIS, April ... LLY ) announced that the U.S. District Court for ... injunction to prevent the launch of a generic version ... Pharmaceuticals until the Court renders its final ruling. Teva ...
... successor identified; Accomplishments during 8-year tenure include reducing expenses, ... in needCHICAGO, April 22 YMCA of Metropolitan Chicago ... plans to retire during a meeting of the Board ... position until a successor is named."Steve Cole has been ...
Cached Medicine News:Health News:First evidence for DNA-based vaccination against chronic hepatitis C 2Health News:LLE Receives Renewal of Women's Business Enterprise National Council Certification 2Health News:Sarasota Veterinary Neurologist Offers Free pet First aid Guide 2Health News:BUSM study finds photographs of UV exposure can impact sunburns in preteens 2Health News:BUSM study finds photographs of UV exposure can impact sunburns in preteens 3Health News:Lilly Granted Preliminary Injunction to Prevent Launch of Generic Raloxifene 2Health News:Lilly Granted Preliminary Injunction to Prevent Launch of Generic Raloxifene 3Health News:YMCA of Metropolitan Chicago CEO Cole Announces Retirement 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: