Navigation Links
Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

first time by Robert C. Green, MD, MPH, of Boston University School of Medicine. Tarenflurbil is classified as a selective amyloid lowering agent, which was shown in nonclinical studies to modulate gamma secretase activity. The drug was in trials in people with mild Alzheimer's to determine if its ability to lower the amount of toxic beta-amyloid would slow or stop the course of the disease.

In the randomized, double-blind, placebo-controlled trial, 1,649 individuals with mild Alzheimer's (mean MMSE in both groups = 23.3) were randomized 1:1 to receive tarenflurbil 800 mg twice-a-day or placebo for 18 months. The co-primary outcome measures of efficacy were two standard measures of cognition and the ability to accomplish activities of daily living, respectively the ADAS-cog and the ADCS-ADL, with assessments conducted every three months. The secondary outcome measure was the Clinical Dementia Rating scale. Exploratory outcomes included the Neuropsychiatric Inventory (NPI), Quality of Life-Alzheimer's test, and Caregiver Burden Inventory.

The researchers found that the drug did not achieve statistical significance in either of its primary endpoints of cognition and activities of daily living. Also, it did not achieve statistical significance on the secondary endpoint. By the end of the 18-month trial, patients in both the tarenflurbil and placebo groups had declined approximately seven points on the ADAS-cog scale and 10 points on the ADCS-ADL scale.

According to the researchers, the reported adverse effects reflect the expected profile of the elderly population with Alzheimer's and, in most participants, symptoms were well balanced between the tarenflurbil and placebo groups. However, in the tarenflurbil treatment group, there was increased frequency of anemia (9.7 percent vs. 4.5 percent), infections (pneumonia, H. zoster, sepsis) (6.9 percent vs. 2.9 percent), and gastrointestinal ulcers (1.7 percent vs. 0.4 percent).

"This was the larg
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Echo Therapeutics Announces Positive Results of a Clinical Study of its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
2. CuraGen Reports Second Quarter 2008 Financial Results and Clinical Progress of CR011-vcMMAE
3. Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results and Provide a Clinical Program Update on August 7, 2008
4. Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation
5. Controversy About Lack of Placebo Group Decline in Alzheimers Clinical Trials
6. Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit
7. Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer
8. Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine)
9. Pharmatech, Inc. Contracts for Five New Just-in-Time Clinical Trials
10. Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
11. Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... , Sept. 19, 2014  Today DePuy ... new variable angle plating systems featuring its proprietary ... can adapt screw trajectory to match patient anatomy ... fragments of bone. The systems are being introduced ... Ankle Society (AOFAS) and the International Federation of ...
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- "United ... 2020″, provides key market data on ... market. The report provides value, in ... (in units) within market categories – ... Esophagoscopes & Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, ...
(Date:9/19/2014)... N.C. , Sept. 19, 2014  For ... cloud-based drug design and development, partnering is an ... mission is to design new drugs and identify ... 2 partners to further their development. The company ... investments. To support this business model, Cloud Pharmaceuticals ...
Breaking Medicine Technology:DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5Cloud Pharmaceuticals Announces Partnering Sessions and Presentation Schedule 2
(Date:9/21/2014)... PhUSE is proud to announce Dr. Pritpal Tamber, ... speakers for their 10th annual conference which is themed ... in 2013 , Charles Sabine in 2012 ... again presents high-calibre speakers to talk about relevant topics ... information. , Dr. Pritpal Tamber is a "health explorer" ...
(Date:9/21/2014)... September 21, 2014 Waldorf Risk ... Management Portal designed for Diocesan risks. The portal ... to support effective risk management and loss control ... live coinciding with Waldorf’s exhibition at the Diocesan ... These applications were developed in collaboration with three ...
(Date:9/21/2014)... CHICAGO (PRWEB) September 21, 2014 ... (IJF BHWG) will host a statewide symposium ( ... Members, Veterans, and their Families. Sponsored by the ... Veteran’s Lottery Cash Grant, and Health & Disability ... 9th at the Hilton Hotel in Springfield, IL. ...
(Date:9/21/2014)... Best Cheap Hosting USA, one of the leading review ... are the best Reseller hosting suppliers in 2014. “It ... Actually, these companies have outperformed their competitors on hosting ... get the best web hosting at affordable rates,” the ... manager, reseller hosting is a very popular way for ...
(Date:9/21/2014)... Rancho del Rio, Colorado (PRWEB) September 21, 2014 ... of Vail, Colorado, ten teams of disabled and able-bodied ... hand cycles, and completed a ropes course in pursuit ... Team Challenge from national non-profit World T.E.A.M. Sports, ... to participating athletes who successfully completed the three stage ...
Breaking Medicine News(10 mins):Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 2Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 3Health News:Waldorf Risk Solutions Releases New Risk Management Portal 2Health News:Enhancing Clinical Competence to Serve Veterans, a Statewide Symposium 2Health News:Enhancing Clinical Competence to Serve Veterans, a Statewide Symposium 3Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3
... new study looking at how hospitals account for the ... (CA-BSIs) found substantial inconsistencies in the methods used to ... The study, conducted by the National Association ... Unit Focus Group, appears in the October issue of ...
... among postmenopausal women in Canada as their use of ... September 23 in The Journal of the National ... (WHI) trial of more than 16,000 postmenopausal women in ... of combined estrogen and progestin hormone replacement therapy outweighed ...
... THURSDAY, Sept. 23 (HealthDay News) -- Sexual problems are common ... In a study of about 1,000 women treated for breast ... a partner reported sexual difficulties, such as loss of desire ... see a large number of women who tell us this ...
... Researchers at Mount Sinai School of Medicine have found that ... from hospice were nearly five times higher than for patients ... far more likely to use emergency department care and be ... issue of the Journal of Clinical Oncology. Led by ...
... University surgeon, investigators found that women who give birth ... double normal rates despite the fact that vaginal delivery ... lingering, yet often treatable, symptoms following their pelvic fracture ... The study, published in Clinical ...
... Sciences (NIEHS) is awarding $36 million in grants to ... workers involved in hazardous waste operations and transportation, environmental ... training programs can receive annual funding for up to ... region will use the money to continue ongoing safety ...
Cached Medicine News:Health News:Study of bloodstream infections reveals inconsistent surveillance methods and reporting 2Health News:Declining breast cancer incidence in Canada with declining HRT usage 2Health News:Sexual Problems May Arise After Breast Cancer 2Health News:Sexual Problems May Arise After Breast Cancer 3Health News:Patients with cancer who stop hospice care boost health-care costs 2Health News:Study finds high rate of c-sections after pelvic fractures 2Health News:NIEHS to fund $36 million in worker safety training 2Health News:NIEHS to fund $36 million in worker safety training 3
... features an advanced design that accommodates both ... gives surgeons the flexibility to easily customize ... is built-in to every aspect of the ... Secure-Twist anti-migration system to the screw options ...
... This system is designed to meet ... by offering an attached locking mechanism and ... standard cases or variable angle screws for ... Atlantis anterior cervical plate system allows the ...
... start with small things. The extremely ... of the trailblazers of the new,generation ... towards ever smaller access and the ... site. ,The HiLAN XS motor concept ...
The CRW system is the premier stereotactic system. The CRW system can be configured as a basic CT-only system, a CT/MR scanner-dependent system, or a high-level CT/MR scanner-independent system with ...
Medicine Products: