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Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

t change the underlying course of the disease. It is widely hoped that the next generation of therapies will be disease modifying, that is, they will slow or stop the brain cell death and loss of function caused by Alzheimer's.

"We must develop better treatments for Alzheimer's that go beyond improving symptoms to drugs that actually change the course of the disease. Delaying the onset of Alzheimer's and slowing the progression of the disease means that millions of people would not get Alzheimer's, and that many who do get the disease might only experience mild symptoms. In addition, delaying the onset and slowing the progression of Alzheimer's in the next five years could generate billions of dollars annually in Medicare and Medicaid savings for nursing home care alone," Gandy said.

Dr. Gandy is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, and Associate Director of the Alzheimer's Disease Research Center at the Mount Sinai School of Medicine, New York City.

18-Month Phase III Trial Results for Tarenflurbil (Flurizan)

Myriad Genetics announced on June 30, 2008, that its Phase III trial of tarenflurbil (Flurizan) had failed to achieve statistical significance on either of its two primary endpoints, and that the company was abandoning development of the compound for Alzheimer's disease.

"While the results of the trial were certainly disappointing, just because the Flurizan Phase III clinical trial failed, doesn't mean that other amyloid-targeted therapies in the clinical trial pipeline aren't valid. We learn a great deal from every clinical study," Gandy said. "There are many ways to impact amyloid and its role in Alzheimer's. There are other drugs in development that target amyloid with mechanisms of action that are different from this one. One or more of these drugs may ultimately prove successful."

At ICAD 2008, detailed data and results from the trial were presented for the
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SOURCE Alzheimer's Association
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