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Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

subgroup of very mild patients. The unadjusted analyses showed no significant effect on the modified ADAS-cog. However, the baseline modified ADAS-cog score was a predictor for the intervention effect. Thus, patients with a higher baseline score showed a greater effect of Souvenaid(TM) on cognition. The investigators noted that there was no decline in modified ADAS-cog and verbal memory in the control group during the 12 weeks of the study.

According to the investigators, Souvenaid(TM) was well tolerated (compliance=94 percent) and showed a good safety profile. The drop-out rate in the study was low - 6.6 percent in first 12 weeks, 4.8 percent in the 12-week extension. They found no significant difference in adverse effects between the study groups throughout the study period.

"We're very excited by these results and we look forward to further research on this product," Scheltens said. "This is an innovative, completely different approach and we believe that medical foods such as Souvenaid(TM) can be a valuable part of Alzheimer's disease management. We're committed to a high level of scientific rigor in the next trial to further test Souvenaid(TM)."

"Souvenaid(TM) is a medical food product backed by 10 years of research. Much of the conceptual work and early pre-clinical work was done at MIT under Professor Richard Wurtman, and supported principally by the National Institutes of Health," Scheltens added.

About ICAD 2008

The 2008 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2008) is the largest gathering of international leaders in Alzheimer research and care ever convened. At ICAD 2008, more than 5,000 researchers from 60 countries will share groundbreaking information and resources on the cause, diagnosis, treatment and prevention of Alzheimer's and related disorders. As a part of the Association's research program, ICAD serves as a catalyst for generating new knowledge about dementia and fosteri
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SOURCE Alzheimer's Association
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