Navigation Links
Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
Date:7/29/2008

- Unsuccessful Phase III Study Does Not Mean the End of Anti-Amyloid Therapies -

CHICAGO, July 29 /PRNewswire-USNewswire/ -- Results from four studies of potential new treatments for Alzheimer's - even an unsuccessful late stage clinical trial - increase the field's knowledge and point scientists toward advances in therapies for the disease, according to research reported today at the 2008 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2008), in Chicago.

The reports included data from:

-- A Phase III trial of tarenflurbil (Flurizan, Myriad), an anti-amyloid therapy, that failed to achieve its primary endpoints.

-- A 12-week, Phase IIa trial of PBT2 (Prana Biotechnology), which reduces the toxic form of amyloid by preventing the interaction of amyloid with copper and zinc in the brain.

-- A 84-week, Phase II trial of methylthioninium chloride (rember(TM), TauRx Therapeutics), a tau aggregation inhibitor that targets toxic tau aggregates, or "tangles." Tangles of tau in the brain are another characteristic hallmark of Alzheimer's.

-- A proof of concept clinical trial in mild Alzheimer's of Souvenaid (Danone Research-Centre for Specialised Nutrition), a "medical food" product that encourages the formation of brain synapses and may reduce beta amyloid.

"While researchers continue to investigate amyloid as a target for Alzheimer's therapies - it is the most mature theory being pursued - we must also examine other potential avenues given the urgency of conquering this disease," said Samuel Gandy, MD, Ph.D., chair of the Alzheimer's Association's Medical and Scientific Advisory Council. "We can't leave any stone unturned if we hope to aid the 5 million people currently living with Alzheimer's and the millions more that will be devastated by this epidemic."

While currently approved treatment options for Alzheimer's offer some relief of symptoms for perhaps a year or two, they do no
'/>"/>

SOURCE Alzheimer's Association
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Echo Therapeutics Announces Positive Results of a Clinical Study of its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
2. CuraGen Reports Second Quarter 2008 Financial Results and Clinical Progress of CR011-vcMMAE
3. Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Second Quarter 2008 Financial Results and Provide a Clinical Program Update on August 7, 2008
4. Emisphere Presents Dramatic Clinical Evidence Demonstrating New Approach to Vitamin B12 Supplementation
5. Controversy About Lack of Placebo Group Decline in Alzheimers Clinical Trials
6. Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit
7. Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer
8. Alexza Initiates Second Phase 3 Clinical Trial for AZ-004 (Staccato(R) Loxapine)
9. Pharmatech, Inc. Contracts for Five New Just-in-Time Clinical Trials
10. Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
11. Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... ZIONA, Israel , June 29, ... BVXV, TASE: BVXV) today announced positive preliminary results from ... candidate for a universal influenza vaccine. In this trial, ... of 50 to 65, followed by an administration of ... later. M-001 was found to be safe and well ...
(Date:6/29/2015)... Calif. , June 29, 2015  Isis Pharmaceuticals, ... has been added to the Russell 1000 Index, effective ... performance of the large-cap segment of the U.S. equity ... Index and includes approximately 1000 of the largest securities ... current index membership. "We are pleased to ...
(Date:6/29/2015)... Calif. , June 29, 2015  Arbor ... medical workstation lineup. The high-powered, multi-functional M2150 ... generation Intel® Haswell Core i5-4402E 1.6 ... provide significant data processing and computing performance. Integrated ... making the unit well suited for graphics-intense applications ...
Breaking Medicine Technology:BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 2BiondVax Presents BVX-006 Preliminary Phase II Results: the Universal Flu Vaccine at Higher Doses is Safe and Improves Immunogenicity in Older Adults 3ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 2ISIS Pharmaceuticals Promoted to the Large-Cap Russell 1000 Index 3Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 2Arbor Solution Introduces Multi-Function Medical Workstation with Large 21.5" True Flat Touch Screen 3
... , CHEYENNE, Wyo., Aug. 24 The ... of its Pay-for-Participation (P4P) program, a component of its innovative ... collaboration between the practitioner community and the Wyoming EqualityCare (EC) ... Wyoming Medicaid members. , , (Logo: ...
... Curemark Founder and CEO Dr. Joan Fallon delivered the ... Conference at Harvard Medical School on July 14th. , ... conclave is particularly significant, since epigenetics is the study of ... in the DNA sequence. Presenters at the session showcased many ...
Cached Medicine Technology:Wyoming Department of Health's Pay-for-Participation Program Reports Positive Clinical Outcomes 2Wyoming Department of Health's Pay-for-Participation Program Reports Positive Clinical Outcomes 3Curemark CEO Presents at Epigenomics Conference 2
(Date:6/29/2015)... ... June 29, 2015 , ... ... announces the Fresh Plus Diaper, a baby invention that makes parenthood less tiring ... projected to reach a market value of USD 52.2 billion in 2017," says ...
(Date:6/29/2015)... ... June 29, 2015 , ... People across the country give their coworkers and families ... of our culture. , But, how often do coworkers donate “life” to the husband ... simple one. , “Dawna (Wright-Thompson) told me her husband was on a donor ...
(Date:6/29/2015)... ... 29, 2015 , ... With Urgent Care Medicine now serving a vital role ... of Urgent Care Medicine and the Medical Society of Delaware to provide its latest ... and health care professionals. , According to Matthew Bader, Exam Master CEO and President, ...
(Date:6/29/2015)... ... 29, 2015 , ... San Fernando Valley skin doctor , Dr. Peyman ... is a special treatment that offers a way to firm sagging facial and neck ... production. Ulthera is highly targeted and precise to help reduce treatment time and improve ...
(Date:6/29/2015)... ... June 29, 2015 , ... New research released today at ... percent of U.S. state and local governments have implemented Next Generation 9-1-1 (NG9-1-1) ... NG9-1-1. , “Mobile phones have surpassed land lines as the primary mode ...
Breaking Medicine News(10 mins):Health News:Bringing Up Baby...Millenials Should Check World Patent Marketing's New Baby Invention 2Health News:Bringing Up Baby...Millenials Should Check World Patent Marketing's New Baby Invention 3Health News:Bringing Up Baby...Millenials Should Check World Patent Marketing's New Baby Invention 4Health News:Bringing Up Baby...Millenials Should Check World Patent Marketing's New Baby Invention 5Health News:VA Pittsburgh Employee Donates Kidney to Coworker’s Spouse 2Health News:Exam Master Partners to Provide New Urgent Care Continuing Medical Education Resource 2Health News:Exam Master Partners to Provide New Urgent Care Continuing Medical Education Resource 3Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 2Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Non-Invasive Skin Tightening Procedures 3Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 2Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 3Health News:State and Local Governments Are Slow to Adopt Next Generation 9-1-1 Systems, According to New Research from General Dynamics Information Technology 4
... as powerful in treating early stage breast cancer as external ... tumour so that a continuous dose// of cancer-killing radiotherapy is ... Michigan found that it has been used with some success ... assigned to either a lose dose or a high dose ...
... Norwegian study of 1656 subjects over an eleven year period ... is linked to a significant increase in respiratory symptoms.// Initially, ... were enrolled in 1985 and asked about lung symptoms, workplace ... ,Then, after 5 years 1656 of the original participants were ...
... to a latest study it is shown that ... a part of their brain responsible for handling ... they often demonstrate// deficits in higher-order thinking abilities, ... response inhibition. These problems lead to the typical ...
... from burns and blisters that are a hazard of radiotherapy. ... curries, its distinctive yellow colour. It is long been known ... fight cancer by cutting off the blood supply to a ... uncover that curcumin has another potential benefit. Working with mice, ...
... According to new researchers, points to the importance of ... their depressed feelings. Researchers feel that with a firm ... with them, //the patient is left with increased feelings ... of Texas performed a unique Internet study to determine ...
... killer that ticks away in one out of every 10 ... the facts and figures trotted out on Sunday at an ... front of the Victoria Statue, Cubbon Park, were officials from ... and the Bangalore Metropolitan Transport Corporation (BMTC). ,The ...
Cached Medicine News:
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: