Navigation Links
Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD
Date:5/20/2008

lf of this year.

"There are still significant unmet needs in the treatment of COPD. These efficacy and safety data from the Phase II trials are very encouraging," said Lawrence S. Olanoff, M.D., Ph.D., President and Chief Operating Officer of Forest Laboratories. "We look forward to the completion of ACCLAIM I & II trials and continuing the clinical development of aclidinium for the treatment of COPD."

Additional Clinical Data

Three additional clinical trials assessing the safety and pharmacokinetics of aclidinium were also presented at this meeting.

A randomized, double-blind, placebo- and active-controlled clinical trial evaluating the cardiovascular safety and pharmacokinetics of aclidinium (200 or 800 mcg) in 272 healthy subjects, showed no effect on QT interval at doses up to 800 mcg. Furthermore, aclidinium was well-tolerated, with most adverse events being of mild intensity, related to electrode attachment, and of similar incidence across treatment groups. Maximum concentration of aclidinium was reached 5 to 30 minutes post-dose and aclidinium was not detectable in the plasma after one hour.

Results of two other randomized, placebo-controlled studies, each in 16 healthy subjects, were presented. In the first, subjects were exposed to single doses of aclidinium (600 -- 6000 mcg) and placebo to determine pharmacokinetics, safety and tolerability, and maximum tolerated dose. For all doses, aclidinium was undetectable in plasma beyond 3 hours post-dose. Aclidinium was well tolerated across this dosage range, with headache (n=10) and fatigue (n=5) being the most frequently reported adverse events. No serious adverse events were reported. The second study assessed the safety, tolerability, and pharmacokinetics of aclidinium after multiple doses. Subjects received 5 days of treatment with aclidinium 200, 400, 800 mcg or placebo. Aclidinium was undetectable in plasma after all studied doses beyond 1 hour post-dose. Aclidinium was we
'/>"/>

SOURCE Forest Laboratories, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies
2. Forest Laboratories, Inc. Announces Positive Results of LEXAPRO(R) Phase III Study in Adolescents With Major Depression
3. Forest Laboratories, Inc. and Gedeon Richter Announce Results of Phase II-B Study for RGH-188 as a Treatment for Schizophrenia
4. Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)
5. Fuisz Tobacco Announces Clinical Study Results for Fuisz Tobacco Sheet Strip; Super Enhanced Bioavailability of Nicotine From Its Tobacco Sheet Strip Supports Efficacy of Low Dose Tobacco Product
6. InterMune Announces Receipt of Fast Track Designation for Pirfenidone From FDA
7. Ipsogen Announces Three Studies at the American Society of Clinical Oncology (ASCO) Meeting Extending the Utility of the Genomic Grade Index for Predicting Response to Chemotherapy in Breast Cancer
8. TAP Pharmaceutical Products Inc. Announces Phase 3 TAK-390MR Data Demonstrating Higher Overall Healing Versus Lansoprazole in Patients with Erosive Esophagitis
9. Pulmo BioTech Announces Details of the Methodology for its Phase I Human Trials
10. GSK Announces Results of First Phase III Trial Evaluating Tykerb(R) (Lapatinib) Plus Herceptin(R) (Trastuzumab)
11. ADVENTRX Announces ANX-530 Safety Data From Registrational Bioequivalence Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , August 29, 2014 ... Seed Oil Market by Extraction type (SFE, Cold ... & Personal Care, Pharmaceutical, Food Supplements, Fragrance, & Others) ... by MarketsandMarkets, defines and segments the Amaranth Seed ... the market size in terms of value. The ...
(Date:8/29/2014)... , Aug. 29, 2014  United Therapeutics Corporation (NASDAQ: ... District Court for the District of New ... the company,s case against Sandoz, Inc. regarding United Therapeutics, ... Sheridan ruled that U.S. Patent No. 6,765,117 is ... Sandoz from marketing its generic product until the expiration ...
(Date:8/29/2014)... Aug. 29, 2014 Diseases largely eradicated in ... ago are returning. Measles was declared eliminated in 2000, ... as of August 15—the highest incidence in 20 years. ... department declared whooping cough a problem of "epidemic ... sick and dying from these preventable diseases—in part because ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... Earlier today, Aethlon Medical, Inc. (OTCBB: AEMD) disclosed ... station news story that included discussion of the company,s ... wounded military personnel.  As previously disclosed, the company submitted ... Broad Agency Announcement (BAA) entitled Dialysis Like Therapeutics (DLT). ...
... VPHM ) first quarter financial results for 2011 ... before the open of the U.S. financial markets. ... webcast at 9:00 a.m. Eastern Time on the same day. ... first quarter financial results and other business. ...
Cached Medicine Technology:Aethlon Medical Clarifies News Report 2Aethlon Medical Clarifies News Report 3Aethlon Medical Clarifies News Report 4Aethlon Medical Clarifies News Report 5ViroPharma to Release 2011 First Quarter Financial Results On April 28, 2011 2
(Date:8/30/2014)... One of the most recent dietary trends to have ... meant for sufferers of gluten intolerance and celiac disease, the ... looking to get healthier by simply consuming foods which are ... information erroneous, it also exposes those same consumers to ... change in their food consumption habits. , Because ...
(Date:8/30/2014)... Removecomplaints.net, a well-known name in the ... to offer guarantee of results with its complaint removal ... because of its tremendous track record. The company has ... over the world and received recommendation letters from many ... On being asked about the announcement, a senior management ...
(Date:8/30/2014)... 30, 2014 Ms. Meriwether’s striking beauty is ... certainly has an impressive resume to boost. Nana is ... 2012. However, she’s also a two time All American ... Nana trained for the 2008 Olympics and played professional volleyball ... “This six-foot beauty from Potomac, Maryland is a two-time, All ...
(Date:8/30/2014)... Tampa, FL (PRWEB) August 30, 2014 ... operated full service auto repair shop with strong ties to ... McLeod Family is happy to announce they have been chosen ... number one pick for auto repair. , Tim McLeod’s ... Park Auto Service sixty years ago. Although his son, Tim ...
(Date:8/30/2014)... 30, 2014 As 500 Zoloft lawsuits pending ... give to pregnant mothers, Wright & Schulte LLC recently learned ... Rufe. The remand in the Zoloft lawsuits was ... states and are involved in one SSRI lawsuit filed ... their Zoloft birth defect lawsuit sent back to the Missouri ...
Breaking Medicine News(10 mins):Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:NJ Top Dentists Announces Cover Model for the Healthy Living: Top Dentists Issue 2Health News:McLeod's Sunset Park Auto Service Celebrates 60 Years Honored with Best of South Tampa 2Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 2Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 3Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 4Health News:Group of Plaintiffs in Zoloft Lawsuit Alleging SSRI Caused Birth Defect Are Granted Remand 5
... Forest University Baptist Medical Center have found out that ... in people with diastolic heart failure, suggesting other potential ... ,'Reduced tolerance for physical activity is the primary ... quality of life,' said Dalane Kitzman, M.D., professor of ...
... Experts from Imperial College London UK opine that new measures ... //Even after mammoth efforts for comprehensive immunization from the health ... happen to be from India. ,According to ... polio in India are due to improper sanitation and congestion ...
... Programme of Nutritional Support to Primary Education (commonly known ... nutritional programme in the world //covering nearly 12 crore ... Scheme (EGS)/Alternative and Innovative Education (AIE) centers. ... minimum 450 calories and 12 gms of protein. The ...
... senator, announced on Thursday that he proposed to introduce ... // ,The bill is better known as "Texas ... other public places would be banned under legislation. ,Ellis made ... the American Cancer Society's Great American Smokeout. ,"Even ...
... wine has contributed to the health ratings of the famous ... laden diets in much the same way as mice on ... earlier study conducted by Harvard Scientists. ,Delving more ... uncorked additional blessings, following a second study conducted on mice. ...
... that both diet and exercise works well for weight loss, ... further suggests those who want to lose weight in their ... room instead of counting calories. ,Both, those who ... weight, according to findings from the study on ‘whether a ...
Cached Medicine News:Health News:Exercise Intolerance In Heart Failure Patients Is Explored By Researchers 2Health News:Exercise Intolerance In Heart Failure Patients Is Explored By Researchers 3Health News:Polio can be eradicated in India: Health Experts 2Health News:Mid-Day Meal Scheme Catches on in India 2Health News:Which Is Better For Losing Weight? - Diet Or Exercise 2
The Mitek Restore System, designed in conjunction with Sanford S. Kunkel, M.D., offers instrumentation for all ACL Procedures....
The Pinn-ACL Guide can be used to create tibial tunnels of known lengths with a variable angle adjustment of 35 to 60 degrees with the use of a,graduated pin-sleeve....
... dermatome can cut a 42 mm wide autograft ... of the 42x42 mm graft required for the ... paediatric and general plastic surgery, especially for primary ... the same dermatome also a wider cutting head ...
... and innovation has resulted in one of ... C is an air dermatome especially engineered ... burn care surgery. The Model C Air ... dedication to quality, durability and reliability that ...
Medicine Products: