Navigation Links
Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD
Date:5/20/2008

Data Presented at the 2008 International Conference of the American

Thoracic Society

TORONTO, May 20 /PRNewswire-FirstCall/ -- Forest Laboratories, Inc. and Laboratorios Almirall, S.A. today presented results from four clinical trials assessing the efficacy and safety of aclidinium bromide, an investigational treatment for chronic obstructive pulmonary disease (COPD). Data from four preclinical studies further describing the properties of aclidinium were also presented at the meeting.

(Logo: http://www.newscom.com/cgi-bin/prnh/20001011/FORESTLOGO )

Presentations included data from a 464-patient randomized, double-blind, four-week, Phase IIb study that evaluated both the efficacy and tolerability of once-daily aclidinium (25 mcg, 50 mcg, 100 mcg, 200 mcg or 400 mcg) or placebo in patients with moderate to severe COPD. An open-label tiotropium (18 mcg) arm was included as an active control. The study demonstrated aclidinium (200 mcg and 400 mcg), administered via a multi-dose dry powder inhaler, significantly increased trough (24-hour) forced expiratory volume in one second (FEV1) -- an important measure of lung function -- on Day 29 compared with placebo (p<0.05 vs placebo). There was a dose response observed for lung function improvement with once-daily aclidinium. Aclidinium was well tolerated, with no dose-dependent effect on ECG, laboratory parameters, or adverse events. Overall, the most frequently reported adverse events were headache (4.1% of patients), dry mouth (2.8% of patients), exacerbation of chronic obstructive airways disease (1.7% of patients) and cough (1.7% of patients). Based on these results, aclidinium 200 mcg administered once every 24 hours was selected as the dose for investigation in the two ongoing Phase III clinical trials, ACCLAIM COPD I and II, which are expected to report out during the second ha
'/>"/>

SOURCE Forest Laboratories, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies
2. Forest Laboratories, Inc. Announces Positive Results of LEXAPRO(R) Phase III Study in Adolescents With Major Depression
3. Forest Laboratories, Inc. and Gedeon Richter Announce Results of Phase II-B Study for RGH-188 as a Treatment for Schizophrenia
4. Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)
5. Fuisz Tobacco Announces Clinical Study Results for Fuisz Tobacco Sheet Strip; Super Enhanced Bioavailability of Nicotine From Its Tobacco Sheet Strip Supports Efficacy of Low Dose Tobacco Product
6. InterMune Announces Receipt of Fast Track Designation for Pirfenidone From FDA
7. Ipsogen Announces Three Studies at the American Society of Clinical Oncology (ASCO) Meeting Extending the Utility of the Genomic Grade Index for Predicting Response to Chemotherapy in Breast Cancer
8. TAP Pharmaceutical Products Inc. Announces Phase 3 TAK-390MR Data Demonstrating Higher Overall Healing Versus Lansoprazole in Patients with Erosive Esophagitis
9. Pulmo BioTech Announces Details of the Methodology for its Phase I Human Trials
10. GSK Announces Results of First Phase III Trial Evaluating Tykerb(R) (Lapatinib) Plus Herceptin(R) (Trastuzumab)
11. ADVENTRX Announces ANX-530 Safety Data From Registrational Bioequivalence Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  The American Diabetes Association is recommending a ... with diabetes and that all people with diabetes ... in keeping with recent changes to guidelines for ... of Cardiology (ACC) and American Heart Association (AHA). ... changes to the Association,s annual revised Standards of ...
(Date:12/24/2014)... 2014  Medical Science Liaisons play a large role ... the medical device industry and key stakeholders, the role ... years as the device industry relies on them to ... by benchmarking firm, Best Practices, LLC, one area where ... is by harnessing new technology to enable education. Online ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research and ... addition of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses ... in the United States . Reimbursement ... studied. Thorough product analyses for more than 73 SMBG ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... The Netherlands, April 29 QIAGEN N.V.,(Nasdaq: QGEN ) today ... Webcast will take place at 9:30 a.m. EDT on,Tuesday, May 6, ... Officer, and Roland Sackers, Chief Financial Officer., What: ... call, When: 9:30 a.m. EDT on ...
... Preliminary results,were released today from a late-stage clinical trial ... did not meet its primary or secondary,endpoints of clinically ... with moderate disease., The findings are initial results ... as the EXPLORER study. Rituxan is approved by the,U.S. ...
Cached Medicine Technology:Webcast of QIAGEN N.V.'s (Nasdaq: QGEN) First Quarter 2008 Financial Results Call Set for May 6 2Statement From the Lupus Foundation of America Regarding the Release of Top-Line Results From a Study of Rituxan for the Treatment of Lupus 2
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... NEW YORK, Oct. 16 BrainStorm Cell,Therapeutics Inc. ... adult,stem cell technologies and therapeutics, is excited and ... author and daughter of renowned,boxer and long time ... the,company,s Advisory Board. BrainStorm has announced results leading ...
... Survey shows many women set but don,t reach exercise goals; ... Association launches Choose To Move Countdown to help, DALLAS, ... exercise during the past 12 months but only 22 percent,achieved ... (Photo: http://www.newscom.com/cgi-bin/prnh/20071016/DCTU003 ) The survey showed that ...
... American Heart Association urges citizens to take precautionary steps, ... the only dangers of winter weather. It,s also a ... especially if you have heart disease.,Following are a few ... and the Flu Every year in the United ...
... 16 Many routine surgical biopsies,could become a ... be sharing,reviewing and diagnosing noninvasive digital images of ... telemedicine server and its,VivaScope(R) confocal imagers. The ... digitally,image a patient,s skin, may bypass the need ...
... to Make A Difference, SEATTLE, Oct. 16 Seattle-based ... easy to make a difference,for women who are newly diagnosed ... e-commerce system so giving is as easy as,clicking a button. ... directly impact the life of a,woman who has been diagnosed ...
... that No Child is Left Behind Due to an Undiagnosed or ... ... In order to ensure that,school-aged children are ready and able to learn, today, ... of 2007 (H.R. 507). According to the AOA, the voice of,34,000 frontline providers ...
Cached Medicine News:Health News:Rasheda Ali to Join Advisory Board of Brainstorm Cell Therapeutics 2Health News:Rasheda Ali to Join Advisory Board of Brainstorm Cell Therapeutics 3Health News:Nine of 10 Women Attempt Exercise Goals After Initial Failure, Survey Shows 2Health News:Nine of 10 Women Attempt Exercise Goals After Initial Failure, Survey Shows 3Health News:Cold Weather Can Increase Heart Disease Risks 2Health News:VivaScope(R) Confocal Imager May Eliminate Need for Routine Skin Biopsies for Dermatology Patients 2Health News:If You Build It, They Will Give 2Health News:Optometry-Backed Vision Care for Kids Act Approved by U.S. House 2Health News:Optometry-Backed Vision Care for Kids Act Approved by U.S. House 3Health News:Optometry-Backed Vision Care for Kids Act Approved by U.S. House 4
CCR Medical conventional laryngoscope handles....
... Wire-Reinforced LMA ™ Airway., ,The ... tube which allows it to be ... while maintaining a good seal. This ... and dental surgery, or other procedures ...
... Airway. , ,Developed for cardiopulmonary resuscitation ... the LMA Fastrach™ has been designed to ... or neck. The LMA Fastrach™ allows continuous ... by emergency teams worldwide including NASA for ...
... in the production of airway ... an integrated solution to all ... single-use Portex Soft Seal Laryngeal ... to this wide portfolio of ...
Medicine Products: