Navigation Links
Forest Laboratories Announces Positive Results from Phase III Clinical Studies of Ceftaroline for the Treatment of Complicated Skin and Skin Structure Infections
Date:6/19/2008

ally conducted, multi-center, Phase III, randomized, double-blind comparative studies were designed to evaluate the efficacy and safety of ceftaroline compared to vancomycin plus aztreonam. The data were collected from 1396 adult patients (702 CANVAS I and 694 CANVAS II), with cSSSI caused by gram-positive and gram-negative bacteria. Over 30% of patients with a confirmed pathogen had a MRSA infection.

Ceftaroline was statistically proven non-inferior to the combination of vancomycin plus aztreonam. Ceftaroline treated patients had a clinical cure rate of 91.6% compared to a vancomycin plus aztreonam clinical cure rate of 92.7% at test-of-cure (TOC) visit in the clinically evaluable population across both studies. The studies were designed to a non-inferiority margin of 10% between ceftaroline and the comparator regimen. In addition, ceftaroline had a microbiological eradication rate of 92.4% compared to a vancomycin plus aztreonam rate of 93.6% for all pathogens when used as treatment for cSSSI. The ceftaroline clinical cure rate was 93.1% in Staphylococcus aureus infections in the microbiologically evaluable population and 93.3% for MRSA infections. The study also indicated that ceftaroline was generally well-tolerated. The overall rate of adverse events was comparable between the two treatment groups. The overall discontinuation rate for ceftaroline was 3.0% compared to 4.8% for vancomycin plus aztreonam.

About Complicated Skin and Skin Structure Infections (cSSSIs)

cSSSIs are caused by gram-positive bacteria, such as MRSA, and common gram-negative bacteria.(1,2) cSSSIs are among the most common infections treated in the hospital setting(3) and MRSA infections are becoming more common in patients in both the hospital and community settings, now the most frequent cause of cSSSI presenting to emergency departments in the United States (U.S.) and the cause of over 18,000 deaths in 2005.(4)

According to the Centers for Disease Control and P
'/>"/>

SOURCE Forest Laboratories, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results
2. Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD
3. Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies
4. Forest Laboratories, Inc. Announces Positive Results of LEXAPRO(R) Phase III Study in Adolescents With Major Depression
5. Forest Laboratories, Inc. and Gedeon Richter Announce Results of Phase II-B Study for RGH-188 as a Treatment for Schizophrenia
6. Daiichi Sankyo and Forest Laboratories Finalize Contract for Co-Promotion of AZOR(TM)
7. Romark Laboratories Completes Enrollment in U.S. Phase II Study of Nitazoxanide for Chronic Hepatitis C Genotype 1 Non-Responders
8. Northfield Laboratories Inc. Presentation at FDA/NIH Workshop on Hemoglobin-Based Oxygen Carriers
9. Romark Laboratories Initiates Phase II Study of Nitazoxanide in Treatment-Naive Patients With Chronic Hepatitis C Genotype 1
10. Romark Laboratories Raises $18 Million in Institutional Financing
11. eRT Announces the Availability of the Suicidality Monitoring System(TM) For Clinical Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... 23, 2013  TeamHealth Medical Call Center (THMCC), ... nurse advice lines, announces its newly formed Clinical ... and administrative leaders, provides clinical expertise to advance ... services for hospital clients, physician clients and patients. ... evolves, it,s imperative to continuously advance our services ...
(Date:5/23/2013)... , May 23, 2013  The need to ... treatment continuum was highlighted prominently at the 108 ... Association (AUA), in San Diego.  According to SonaCare ... focused ultrasound (HIFU) technology, the need for image-guided ... for urologists to consider minimally invasive ablative treatments, ...
(Date:5/23/2013)... 2013  Texas, premier physician associations today announced the ... tools they need to provide demonstrably better and more ... marketplace. "I am confident the Physician Services ... Stephen L. Brotherton , MD, president ... doctors are determined to make health care ...
Breaking Medicine Technology:TeamHealth Medical Call Center Forms Clinical Advisory Committee 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4
... Fla., Nov. 13 /PRNewswire/ Millar Instruments, Inc., developer ... pressure-volume (P-V) systems, and Transonic Systems, Inc., global ... flow measurement devices, today announce a new distribution ... two giants in the field of physiological measurements, ...
... , SUNNYVALE, Calif., Nov. 13 Walt Maclay, ... ), has been selected to speak on "Data ... on December 9, 2009. BIOMEDevice ( http://www.devicelink.com/expo/biomed09/index.html ... together industry leaders in medical devices. The show ...
Cached Medicine Technology:Millar Instruments and Transonic Systems, Suppliers of Gold Standard Pressure and Flow Products, Enter Into Mutual Distribution Agreement 2Voler Systems President Speaks at BIOMEDevice San Jose 2Voler Systems President Speaks at BIOMEDevice San Jose 3
(Date:5/24/2013)... FRIDAY, May 24 (HealthDay News) -- Low-income, minority ... sexual activity and are more open to vaccinating ... (HPV), a small new study contends. Conversely, ... off vaccination for their daughters, according to researchers ... "Approximately 33,000 Americans will get an HPV-related cancer ...
(Date:5/24/2013)... CA (PRWEB) May 24, 2013 American ... care education community, proudly participated in festivities surrounding the ... 19-21. The event provided the perfect backdrop to introduce ... at 236 E. 3rd Street, housed in an architectural ... Building. , ACC was an active exhibitor throughout the ...
(Date:5/24/2013)... 24, 2013 The SunglassFIX Photo ... sunglasses all while learning how to make their ... Contestants only need to upload pictures of ... "like" The Sunglass Fix on Facebook in order ... the largest lens replacement online store . ...
(Date:5/24/2013)... A new discovery at Oregon Health & Science ... effectively reacts when infected with the highly evasive HIV ... has been utilizing this unique approach to develop its ... promising results in animal studies. This latest research finding ... of the journal Science . , "A ...
(Date:5/24/2013)... 2013 Residents of San Diego have ... classes. Fitness expert, and Certified Russian Kettlebell Instructor, Cody ... Bootcamps in San Diego, California. The classes take place ... times offered. Initial sign-ups are available online and ... teaching Kettlebell for years. The bootcamps being offered ...
Breaking Medicine News(10 mins):Health News:Low-Income, Minority Parents More Open to HPV Vaccine for Girls, Study Says 2Health News:American Career College Revs Up Community Support During Toyota Grand Prix of Long Beach 2Health News:Break the Sunglass Mold – Reuse 'Em, Don’t Toss 'Em then Enter the SunglassFIX Photo Contest to Win 2Health News:OHSU research highlights promising strategy to help vaccines outsmart HIV 2
... ... with a plan that is customized to them? Want to keep the weight off permanently and ... , ... Loss announces that the new online company continues to expand its website and its customer base, ...
... ... invasive approaches toward imaging-guided percutaneous—or through the skin—techniques, according to a new study appearing ... , ... IL (Vocus) June 29, 2010 -- Advanced imaging technologies have helped shift biopsy techniques ...
... Gardner HealthDay Reporter , MONDAY, June 28 ... clinical trials, the diabetes drug Avandia does raise the odds ... drug,s risks might outweigh its benefits in people with type ... increased risk for death from cardiovascular disease, said the authors ...
... , MONDAY, June 28 (HealthDay News) -- A new study ... statins are a third less likely to suffer from recurrences ... prescribe a statin -- drugs such as Crestor, Lipitor ... aren,t firm enough for doctors to make a blanket recommendation ...
... anterior cruciate ligaments (ACL) or meniscal cartilage injuries in the ... to a new study published in the online edition and ... A decade after the initial injuries were diagnosed using ... whether or not the injuries had been surgically repaired. ...
... for watching too much TV. It turns out that their ... TV, and it is not good for them either, according ... and Rady School of Management at the University of California, ... online in advance of publication in the August issue of ...
Cached Medicine News:Health News:Brilliance Weight Loss Takes Dieters Beyond Trendy Low Fat Diets 2Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 2Health News:Use of Less Invasive, Imaging-Guided Biopsies on the Rise 3Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 2Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 3Health News:Diabetes Drug Avandia Ups Heart Risk, Reviews Conclude 4Health News:Statins May Lower Rates of Prostate Cancer Recurrence 2Health News:Surgical repair of knee injuries does not decrease risk of osteoarthritis 2Health News:Older adults watch more TV than younger people, enjoy it less 2
The Storz Premiere comes as anterior, posterior and anterior/posterior combo. The combo provides the following modes irrigation, irrigation/aspiration, vitrectomy, and illumination....
... Phacoemulsification System is a ... system. Lightweight and portable, ... and features in a ... provides all modes necessary ...
Compact ultrasonic phacoemulsification system....
Phaco-emulsification systems CV series...
Medicine Products: