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Forest Laboratories, Inc. Announces Positive Results of LEXAPRO(R) Phase III Study in Adolescents With Major Depression
Date:11/29/2007

erapy, cognitive- behavior therapy, interpersonal therapy and medication play an important role in the management of their illness.(2) Patients on antidepressant treatment should also be closely monitored by healthcare providers, family members and other caregivers.

About LEXAPRO

LEXAPRO is an SSRI being studied as a treatment for adolescents with MDD. LEXAPRO is indicated for the initial and maintenance treatment of major depressive disorder and generalized anxiety disorder (GAD) in adults. LEXAPRO is thought to work by helping to restore the brain's chemical balance. It is believed to increase the availability of serotonin, a substance in the brain believed to influence mood. In adults, LEXAPRO 10 mg/day is a well-tolerated therapy, with drop-out rates due to adverse events comparable to placebo in depression and low in the treatment of GAD. LEXAPRO has been prescribed to over 16 million people.(11)

Important LEXAPRO Information

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Antidepressants increased the risk of suicidality (suicidal thinking and behavior) in children, adolescents, and young adults in short-term studies in Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of antidepressants in children, adolescents, or young adults must balance the risk to clinical need. Patients of all ages started on antidepressant therapy should be closely monitored and observed for clinical worsening, suicidality, or unusual changes in behavior, especially at the beginning of therapy or at the time of dose changes. This risk may persist until significant remission occurs. Families and caregivers should be advised of the need for close observation and communication with the prescriber. LEXAPRO is not approved for use in pediatric patients.

LEXAPRO is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), pimozide, or
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SOURCE Forest Laboratories, Inc.
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