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For Treatment of Irritable Bowel Syndrome, Linaclotide Will Emerge as the Market Leader and Will Achieve Blockbuster Status in 2019

BURLINGTON, Mass., Dec. 16, 2010 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, owing to its superb efficacy, acceptable safety profile and anticipated launch in all major markets, Ironwood/Forest/Almirall/Astellas's linaclotide will emerge as the market leader for the treatment of irritable bowel syndrome (IBS). In 2019, linaclotide will garner blockbuster sales of $1.1 billion in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.

Although Sucampo/Takeda/Abbott's Amitiza was the IBS drug market leader in 2009, the drug's limited efficacy, loss of patent protection and competition from linaclotide will cause Amitiza's sales to drop sharply through 2019.

The findings from the Pharmacor topic entitled Irritable Bowel Syndrome, which will publish later this month, reveal that the overall IBS drug market will expand at a 14 percent annual rate from 2009 to 2019, owing to the market entry of much-needed first-in-class therapies.

The findings also reveal that, because of the heterogeneity of IBS and the high rate of generic penetration, the IBS therapy market is highly fragmented and underserved. The lack of prescription therapies that can address more than one symptom of the disease means that physicians and patients resort to using multiple drugs, many of which are inadequate at controlling motility or pain symptoms associated with IBS. Additionally, owing to the combination of high prevalence and low diagnosis rates, substantial commercial potential exists for the development of drugs that target this indication.  

"IBS is a highly prevalent chronic condition in the world's major pharmaceutical markets, but the lack of a biochemical or histological marker for positive diagnosis and incomplete understanding of the disease's pathophysiology and etiology have resulted in low diagnosis and treatment rates," said Decision Resources Analyst Iva Holder, Ph.D. "The limited number of efficacious treatment options suggests significant opportunity for new IBS therapies."

About Decision ResourcesDecision Resources ( is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.

About Decision Resources, Inc.Decision Resources, Inc. is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources, Inc. at

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.For more information, contact:Decision Resources, Inc.Christopher Comfort781-993-2597

SOURCE Decision Resources
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