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For Treatment of Extensive-Disease Small-Cell Lung Cancer (ED-SCLC), No Emerging Therapy is Likely to Replace Etoposide/Carboplatin as the Standard of Care Before 2022
Date:4/23/2013

BURLINGTON, Mass., April 23, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, despite the numerous therapies in clinical development for extensive-disease small-cell lung cancer (ED-SCLC), no emerging therapy is likely to replace etoposide (Bristol-Myers Squibb's Etopophos/VePesid, generics)/carboplatin (generics) as the standard of care before 2022. Interviewed experts complain that treatment for SCLC has changed very little in decades, and—given the challenges of treating this aggressive disease and the current clinical pipeline—experts are pessimistic that the treatment landscape will improve in the near future.

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The DecisionBase 2013 report entitled How Receptive Would Oncologists and Payers Be to Therapies That Partially Address the Unmet Needs of Patients with Advanced Disease? finds that surveyed U.S. and European oncologists agree that increasing overall survival (OS) is one of the greatest unmet needs in ED-SCLC. Despite high response rates with first-line therapy, most patients relapse within a year after treatment and survival rates remain dismal. Experts admit that, should efficacy benefits be seen with therapies in development—such as Ziopharm Oncology's Zymafos, Bristol-Myers Squibb's Yervoy, Genentech/Roche/Chugai's Avastin or Immunogen's lorvotuzumab mertansine—these benefits will likely be only incremental improvements that will not transform current treatment practice. According to the findings, a drug that offers marked improvement in survival presents a strong commercial opportunity to developers, although no drug in clinical development is expected to imp
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