Navigation Links
Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, in Relapsed/Refractory Mantle Cell Lymphoma Presented at American Society of Hematology Annual Meeting
Date:12/11/2012

edian time to response to treatment with ibrutinib was 1.9 months for first PR (range of 1.4 to 9.1 months) and 5.5 months for first CR (range of 1.7 to 16.4 months).

Safety data were available for 111 patients in the trial. Patients treated with ibrutinib experienced treatment-emergent adverse events (AEs) that were consistent with previously reported data. Treatment-emergent AEs were mainly grade 1 or 2. Treatment-emergent AEs of all grades occurring in 20 percent or more patients were diarrhea, fatigue, nausea, upper respiratory tract infection and dyspnea (shortness of breath). Pneumonia was the only grade 3 or higher treatment-emergent AE occurring in 5 percent or more patients.

"We are encouraged by the rate and durability of response and the tolerability profile suggested in these Phase 2 study follow-up findings, and look forward to enrolling and seeing results from additional Phase 2 and Phase 3 trials," said Peter Lebowitz, M.D., Ph.D., Global Oncology Therapeutic Area Head, Janssen. "Our collaboration with Pharmacyclics to co-develop ibrutinib in a broad range of B-cell malignancies is part of Janssen's longstanding commitment to apply innovative science to address the most critical unmet needs."

Study Details

PCYC-1104-CA is an international, multicenter, open-label, Phase 2, single-agent study that treated 111 patients (63 bortezomib-naive patients and 48 bortezomib-exposed patients) with relapsed or refractory MCL. Patients were treated with oral ibrutinib 560 mg daily for continuous 28-day cycles until disease progression. The primary endpoint of the study is ORR, and secondary endpoints include duration of response (DOR), PFS, overall survival (OS) and safety/tolerability. The study was conducted by Pharmacyclics.

About Mantle Cell Lymphoma

MCL is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) that usually occurs in middle-aged or older adults. The disease typically begins in the lymph nodes but ca
'/>"/>

SOURCE Janssen Research & Development, LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, Suggest High and Durable Responses in Relapsed/Refractory Mantle Cell Lymphoma
2. Six-Year Follow-Up Data for SPRYCEL®? (dasatinib) 100 mg Once Daily Demonstrates 71 Percent Overall Survival in Patients with Chronic-Phase Chronic Myeloid Leukaemia Resistant or Intolerant to Imatinib
3. Landauer, Inc. Reports Fiscal 2012 Fourth Quarter And Year End Results
4. Ambit and Astellas Announce Presentation of Results from Phase 2 ACE Study of Quizartinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) at the 54th Annual Meeting of the American Society of Hematology
5. IRIDEX Corporation Announces Preliminary Results of its Tender Offer
6. American Pacific to Release Financial Results and Hold Fiscal 2012 Year-End and Fourth Quarter Investor Teleconference
7. PNAS Publishes Preclinical Results of EntreMeds 2ME2 for Multiple Sclerosis
8. The Female Health Company Reports Record Fourth Quarter and FY2012 Operating Results
9. ObeTherapy Announces the Publication of Results Obtained with one of its Lead Compounds on a New Target for the Treatment of Obesity and Type II Diabetes
10. InspireMD to Discuss MGuard(TM) and the MASTER Randomized Trial Results at the ICI 2012 Meeting
11. Landauer, Inc. Sets Date And Time For Announcement Of Fiscal Fourth Quarter And Full Year 2012 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... SOUTH SAN FRANCISCO, Calif. , Aug. 3, ... therapeutics for the treatment of cancer, today announced ... team. Debanjan Ray , who ... and alliance management, has been promoted to senior ... to joining CytomX, Mr. Ray held positions as ...
(Date:8/3/2015)... FLORHAM PARK, N.J. , Aug. 3, ... met its primary and secondary endpoints in a phase ... constipation (OIC) in adult patients with chronic non-cancer pain. ... antagonist (PAMORA). This is the third Phase III trial ... endpoints. Study results showed that a 0.2 ...
(Date:8/3/2015)... (PK:ECIA), a medical device company owning patented surgical technology ... surgery, today announced financial results for its fiscal 2016 ... The Company posted quarterly net revenue of $2.454 million ... $(0.02) per share. These results compare to net revenue ... thousand, or $(0.02) per share, in the year-ago quarter. ...
Breaking Medicine Technology:CytomX Announces Management Team Promotions 2CytomX Announces Management Team Promotions 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Naldemedine Meets Primary Endpoint In Phase 3 Study For The Treatment Of Opioid-Induced Constipation 4Encision Reports First Quarter Fiscal Year 2016 Results 2Encision Reports First Quarter Fiscal Year 2016 Results 3Encision Reports First Quarter Fiscal Year 2016 Results 4Encision Reports First Quarter Fiscal Year 2016 Results 5
... 15 Watermark Medical , Inc., a privately-held, ... market, has expanded the market reach of its Web-enabled ... three leading sleep solution providers in the U.S. and ... national provider of comprehensive sleep apnea services; Sleep ...
... Vista Partners announced today that it has updated ... Principal Analyst at Vista Partners stated, "Raptor is potentially ... a balanced pipeline of clinical and preclinical programs.  The ... programs and one Phase 3 trial with some indications ...
Cached Medicine Technology:Three Leading Sleep Solution Providers Choose Watermark Medical's Web-Enabled Home Sleep Testing Solutions 2Three Leading Sleep Solution Providers Choose Watermark Medical's Web-Enabled Home Sleep Testing Solutions 3Three Leading Sleep Solution Providers Choose Watermark Medical's Web-Enabled Home Sleep Testing Solutions 4
(Date:8/3/2015)... Angeles, CA (PRWEB) , ... August 03, 2015 , ... According to an opinion ... calories out of person’s diet leads to one pound of weight loss may not be ... caloric reduction that translates to one pound of fat varies – based both on the ...
(Date:8/3/2015)... , ... August 03, 2015 , ... ... Infectious diseases researchers from the University of Pittsburgh School of Medicine are leading ... HIV prevention drugs in sub-Saharan Africa. , A cooperative agreement awarded by ...
(Date:8/3/2015)... (PRWEB) , ... August 03, ... ... bodybuilding and fitness site and the largest online retailer of nutritional supplements, ... BPI Sports is up for 11 awards in the following categories:, ...
(Date:8/3/2015)... TAMPA, Florida (PRWEB) , ... August 03, 2015 ... ... Association for Physician Leadership ® and Navigant Center for Healthcare Research and Policy ... nationwide. , Fifty-five percent of respondents said they agreed or strongly agreed that ...
(Date:8/3/2015)... ... , ... A July 9 article from USA Today has revealed ... the American Dental Association. According to a study by the American Dental Association, from ... a single year to 2.2 million a year. Dentists and ADA officials all point ...
Breaking Medicine News(10 mins):Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 2Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 3Health News:$5M Effort to Guide Use of HIV Prevention Meds in Africa 4Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 2Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 3Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 2Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 3Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 2Health News:Los Angeles Periodontists Comment on Rising Dental Emergency Room Trips 3
... , This release is available in ... Patients suffering from two serious autoimmune disorders which ... cardiovascular disease, says a group of Montreal researchers. Dr. ... Institute of the McGill University Health Centre (RI-MUHC) have ...
... Additional Speakers and New Sessions Added to ... , , MINNEAPOLIS, Sept. 1 ... has added several speakers and new sessions to the most comprehensive ... Compliance and Ethics Institute, being held September 13 - 16, 2009, ...
... , , , ... Audiopoint, a leading provider of innovative voice data solutions, ... of automated patient management services. NotifierRx will help hospitals ... by automating outpatient follow-up with interactive voice-controlled services. , ...
... , , , OAKLAND, ... of the Thrive advertising campaign, with television, radio, print and online ... health of its members and the communities it serves. , ... -- illustrate Kaiser Permanente,s leadership in leveraging health information technology. As ...
... , , , , ... NTRI ), a leading provider of weight management programs ... to offer consumers striving for a late-summer shape up, some easy, top-of-mind ... long. , , According to Sansone, ...
... Industry Veteran to Lead PI Pharmaceutical Business Unit ... Physicians Interactive LLC (PI), a leader in digital sales and marketing ... Pingle has been named President of PI. Pingle will report to ... lead the company,s pharmaceutical business unit. , , ...
Cached Medicine News:Health News:Researchers link inflammatory diseases to increased cardiovascular risk 2Health News:Cynthia Cooper, Time Magazine's Person of the Year and former WorldCom Auditor to Address the 8th Annual Compliance and Ethics Institute, September 13-16, 2009, Planet Hollywood, Las Vegas, NV 2Health News:Cynthia Cooper, Time Magazine's Person of the Year and former WorldCom Auditor to Address the 8th Annual Compliance and Ethics Institute, September 13-16, 2009, Planet Hollywood, Las Vegas, NV 3Health News:Cynthia Cooper, Time Magazine's Person of the Year and former WorldCom Auditor to Address the 8th Annual Compliance and Ethics Institute, September 13-16, 2009, Planet Hollywood, Las Vegas, NV 4Health News:Cynthia Cooper, Time Magazine's Person of the Year and former WorldCom Auditor to Address the 8th Annual Compliance and Ethics Institute, September 13-16, 2009, Planet Hollywood, Las Vegas, NV 5Health News:Audiopoint Adds Voice to Healthcare Reform Debate 2Health News:Audiopoint Adds Voice to Healthcare Reform Debate 3Health News:Kaiser Permanente Debuts New Ads Focused on Technology and Innovation 2Health News:Kaiser Permanente Debuts New Ads Focused on Technology and Innovation 3Health News:Walk the Weight Off with Shape Up Tips from Leading National Walking Expert Leslie Sansone and Nutrisystem 2Health News:Walk the Weight Off with Shape Up Tips from Leading National Walking Expert Leslie Sansone and Nutrisystem 3Health News:Walk the Weight Off with Shape Up Tips from Leading National Walking Expert Leslie Sansone and Nutrisystem 4Health News:Walk the Weight Off with Shape Up Tips from Leading National Walking Expert Leslie Sansone and Nutrisystem 5Health News:Walk the Weight Off with Shape Up Tips from Leading National Walking Expert Leslie Sansone and Nutrisystem 6Health News:Physicians Interactive Names Sanjay Pingle President 2Health News:Physicians Interactive Names Sanjay Pingle President 3
... Markers have a unique squeezable barrel ... writing over wet prep solutions. Micro ... with optional rulers and sterile labels ... sterile, packaged individually in peel pouches. ...
Broad tip, gentian violet, sterile, disposable...
... The Surgifoam* absorbable gelatin sponge, U.S.P. ... gelatin absorbable sponge intended for hemostatic ... surface. The sponge is off-white and ... speed to hemostasis, highly favorable surgeon ...
9 mm diameter pigtail curved blunt probes. Stainless steel. Round knurled handle with polished finish. Includes pre-cut polyethylene tubes. Overall length: 5.9 inches....
Medicine Products: