Navigation Links
Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, Suggest High and Durable Responses in Relapsed/Refractory Mantle Cell Lymphoma
Date:12/11/2012

e complete response."

Relapsed MCL means the disease has returned after an initial partial or total remission. Refractory MCL refers to cancer that does not respond to current treatment.

Safety data were available for 111 patients in the trial. Patients treated with ibrutinib experienced treatment-emergent adverse events (AEs) that were consistent with previously reported data. Treatment-emergent AEs were mainly grade 1 or 2. Treatment-emergent AEs of all grades occurring in 20 percent or more patients were diarrhea, fatigue, nausea, upper respiratory tract infection and dyspnea (shortness of breath). Pneumonia was the only grade 3 or higher treatment-emergent AE occurring in 5 percent or more patients.

"These results are encouraging because they suggest ibrutinib provided a durable response in the treatment of mantle cell lymphoma in this Phase 2 study," said Bob Duggan, CEO and Chairman of the Board of Directors of Pharmacyclics. "Pharmacyclics' overall mission is to improve the quality and duration of life for oncology patients."

Study Details

PCYC-1104-CA is an international, multicenter, open-label, Phase 2, single-agent study that treated 111 relapsed or refractory patients (63 bortezomib-naive and 48 bortezomib-exposed) with oral ibrutinib 560 mg daily for continuous dosing until disease progression. The primary endpoint of the study is ORR. Duration of response and safety evaluation are important secondary endpoints.

About Mantle Cell Lymphoma

MCL is an aggressive type of B-cell non-Hodgkin lymphoma (NHL) that usually occurs in middle-aged or older adults. The disease typically begins in the lymph nodes but can spread to other tissues, such as bone marrow and liver. In the United States, there are approximately 70,130 new cases of NHL and 4,600 new cases of MCL each year.

About Ibrutinib

Ibrutinib was designed to specifically target and selectively inhibit an enzyme called Bruton's tyrosine kin
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Six-Year Follow-Up Data for SPRYCEL®? (dasatinib) 100 mg Once Daily Demonstrates 71 Percent Overall Survival in Patients with Chronic-Phase Chronic Myeloid Leukaemia Resistant or Intolerant to Imatinib
2. Cell Therapeutics, Inc. (CTI) to Report First Quarter Financial Results on April 20
3. VeriStrat® Test Results Correlate with Survival Outcomes in Advanced Lung Cancer
4. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
5. Alexza to Announce 2012 First Quarter Financial Results on Thursday, May 10, 2012
6. 3SBio Inc. Schedules Unaudited First Quarter 2012 Results
7. Simcere Pharmaceutical Group to Announce First Quarter 2012 Financial Results on Wednesday, May 9, 2012
8. Perrigo Company Will Release Third Quarter Fiscal 2012 Results On May 8, 2012
9. Genomic Health to Announce First Quarter 2012 Financial Results and Host Conference Call on Wednesday, May 2, 2012
10. Nektar to Announce Financial Results for the First Quarter of 2012 on Wednesday, May 2, 2012, After Close of U.S.-Based Financial Markets
11. STAAR Surgical Announces First Quarter 2012 Results Release Date and Conference Call and Webcast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)...  AT&T 1 and Royal Philips ... the connectivity provider for Philips GoSafe, Philips, leading mobile ... peace of mind to seniors at home or on ... lives with the confidence that they can get help ... 2 helps power GoSafe and connects seniors with ...
(Date:3/3/2015)... 3, 2015 Today, the Partnership for ... America,s biopharmaceutical research companies, unveiled a redesigned ... provide patients and caregivers with faster, easier access ... private patient assistance programs. Since ... platform to engage, educate and empower patients and ...
(Date:3/3/2015)... , March 3, 2015 - ... 26 June 2015, SNIEC, Shanghai, China ... 10th P-MEC China, will be held at Shanghai New International ... P-MEC China originated from CPhI Worldwide and was introduced to ... important bridge between Chinese pharmaceutical companies and global pharmaceutical industry ...
Breaking Medicine Technology:AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 3AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 4Partnership for Prescription Assistance Relaunches Website with New Features for Patients and Caregivers 215th Anniversary, Be Part of Chinese Pharma Dream 215th Anniversary, Be Part of Chinese Pharma Dream 3
... DUBLIN, Calif., July 1 SuperGen ... the discovery, rapid,development and commercialization of therapies ... on the preliminary efficacy,data from a trial, ... to best supportive care (BSC) in elderly ...
... July 1 Pressure,BioSciences, Inc. (Nasdaq: PBIO ... York University ("NYU") School of Medicine and the ... made in the,areas of breast and colon cancer, ... generated in studies using PBI,s patented,pressure cycling technology ...
Cached Medicine Technology:SuperGen Comments on Preliminary Efficacy Update on EORTC Phase 3 Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes 2SuperGen Comments on Preliminary Efficacy Update on EORTC Phase 3 Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes 3SuperGen Comments on Preliminary Efficacy Update on EORTC Phase 3 Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes 4Pressure Cycling Technology (PCT) Results in a Higher Yield of Proteins and in the Extraction of Proteins Not Previously Identified in Cancer, Stroke, and IVF Studies 2Pressure Cycling Technology (PCT) Results in a Higher Yield of Proteins and in the Extraction of Proteins Not Previously Identified in Cancer, Stroke, and IVF Studies 3
(Date:3/3/2015)... 03, 2015 DePuy Pinnacle hip ... version of the artificial hip system caused recipients ... move forward in the federal multidistrict litigation underway ... According to the most recent Master Case List ... 7,350 Pinnacle hip replacement lawsuits are now pending ...
(Date:3/3/2015)... BC (PRWEB) March 03, 2015 The ... doubled since 1984 to about 15%. This increases to ... old. (Bushnik T, Cook JL, Yuzpe AA, et al. ... 2012; 27: 738-46). Dr. Jason Hitkari, a reproductive endocrinologist ... a doctor of TCM and clinical director and founder ...
(Date:3/3/2015)... The North America application delivery network ... million to $1,694.6 million, at a CAGR ... Browse through the TOC of North America ... of industry trends and segments, with the ... http://www.micromarketmonitor.com/market/north-america-application-delivery-network-adn-7381582251.html , An application delivery network ...
(Date:3/3/2015)... 2015 Splashtop Inc. , the ... is now available for Epson® MoverioTM BT-200 smart glasses. ... Moverio Apps Market , iPod, iPhone, and iPad users ... the Epson Moverio smart glasses using Mirroring360, enhancing the ... , The Epson smart glasses have an advanced binocular ...
(Date:3/3/2015)... OncLive® and Indiana University Melvin and ... share news about the center’s research and education ... of OncLive’s Strategic Alliance Partnership initiative. , ... teams will partner with the IU Simon Cancer ... highlight accomplishments. They include the center’s recent National ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 2Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 3Health News:DePuy Pinnacle Lawsuit News: Bernstein Liebhard LLP Comments on Growing Pinnacle Hip Litigation 4Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 2Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 3Health News:New Treatment Approach Helps Boost Chance of Pregnancy; Information Seminar at Olive Fertility Center 4Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 2Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 3Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 2Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 3Health News:IU Simon Cancer Center Teams with OncLive® in Strategic Alliance Partnership 2Health News:IU Simon Cancer Center Teams with OncLive® in Strategic Alliance Partnership 3
... 27 /Xinhua-PRNewswire-FirstCall/ -- Mindray,Medical International Limited (NYSE: ... marketer of medical devices worldwide, today announced ... executive officer, Mr. Minghe,Cheng, Mindray,s executive vice ... Mindray,s investor relations manager, will attend the ...
... electronic health records now available worldwide, ... General Lt. Gen.,Eric B. Schoomaker today announced ... a comprehensive electronic health record,led by the ... or MC4,provides digital recording capabilities and access ...
... OAK BROOK, Ill. A new calcium scoring method may ... a new multicenter study published in the June issue of ... only the amount of calcified plaque build-up in the coronary ... the location of the calcium in the arteries is particularly ...
... summer days ahead and the,delights of a good book ... "Lifeliner: The Judy Taylor story," the debut book from ... inspiring summer read, it tells the poignant story of ... first person to live,decades on intravenous feeding without eating ...
... Nearly half of patients with a history of heart disease ... and do not perceive themselves to have an elevated cardiovascular ... of Archives of Internal Medicine, one of the JAMA/Archives journals. ... times the risk of having a heart attack or dying ...
... DALLAS May 26, 2008 Adding noninvasive imaging ... are at risk of developing heart disease, UT Southwestern ... from the UT Southwestern-led Dallas Heart Study to determine ... for calcium deposits and blockages could identify more people ...
Cached Medicine News:Health News:Mindray to Attend Goldman Sachs 29th Annual Global Healthcare Conference 2Health News:Life-Saving Technology Expands Globally to Military Branches - Transforming the Way Medical Care is Documented on the Battlefield 2Health News:Coronary calcium distribution tied to heart attack risk 2Health News:An Inspiring Summer Read: Biography of Judy Taylor - The Woman Who Could Not Eat 2Health News:Many patients with heart disease have poor knowledge of heart attack symptoms 2Health News:Many patients with heart disease have poor knowledge of heart attack symptoms 3Health News:Increased screening may better predict those at higher risk for heart disease, researchers report 2
... blade. The I.V. Macintosh blade is concave ... visualization. Rusch offers a reliable tradition of ... designs of these blades have been continually ... world over to minimize maintenance requirements. They ...
Rigid plastic. Single use. Non-Sterile. The disposable laryngoscope blade that fits on a standard handle. Made of extremely rigid plastic. Bright white light out-performs metal blades. Single patient...
... allows visualization of the vocal cords in even ... to function like a standard laryngoscope, Viewmax® does ... lies in its ability to allow intubation whether ... or IV airway. It has a patented lens ...
... be used with Portex® reusable or disposable ... with long-lasting bronze fiber-optic bundles provide the ... use., ,The laryngoscope blades are available ... infant to large adult, and in all ...
Medicine Products: