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Focus Diagnostics Launches Laboratory Test for Chikungunya Virus

First Laboratory Developed Test in the U.S. for Detecting the

Mosquito-Borne Infectious Disease

CYPRESS, Calif., Feb. 15 /PRNewswire/ -- Focus Diagnostics, Inc., the infectious disease diagnostics company of Quest Diagnostics (NYSE: DGX), today announced the first laboratory developed test in the U.S. for detecting the mosquito-borne chikungunya virus. Commercial availability of the molecular polymerase chain reaction (PCR) test will enable physicians in the U.S. to test patients who may have contracted the virus, such as individuals returning from regions in Africa and Asia where chikungunya is endemic. The U.S. Centers for Disease Control and Prevention (CDC) has suggested that the chikungunya virus, which caused an outbreak in Italy in 2007, has the potential to enter and spread in the U.S.

"The availability of our chikungunya virus PCR test will give healthcare providers in the U.S. an important option for identifying patients, particularly travelers, who may be infected with this potentially disabling virus," said Dr. Jay M. Lieberman, medical director, Infectious Diseases, Focus Diagnostics. "In recent years, Focus Diagnostics has brought to market new diagnostic tests that physicians can use to diagnose emerging infectious diseases, such as West Nile Virus and SARS. If chikungunya emerges in the U.S., our test could become an important tool to help mobilize an effective public health response. Chikungunya is a challenge to diagnose because its symptoms can mimic those of other diseases, including other mosquito-borne diseases, so the availability of an accurate diagnostic test is essential to minimize spread of the disease."

The chikungunya virus test is a molecular assay that employs PCR, a highly sensitive and commonly used testing method that can detect the presence of the virus' RNA in a patient's blood. Physicians can use test results in conjunction with clinical symptoms to diagnose a patient's infection with the virus. Until now, testing for chikungunya virus was not commercially available in the U.S. and specimens were referred to a public health laboratory, which could take a week or more to report results. Focus Diagnostics expects to be able to provide physicians with test results within a day of receiving a sample for testing.

Chikungunya's symptoms include fever, rash and joint pain, as well as headache, fatigue, nausea, vomiting and muscle pain. Death from the disease is rare, but long-term health effects can include disabling joint pain that persists for weeks or months. There is no vaccine or antiviral treatment for the disease.

In recent years, chikungunya has exhibited potential to spread to new regions. The CDC has reported that some travelers who visited India during an epidemic in 2006 that affected approximately 1.25 million individuals returned to the U.S. infected with the virus. The World Health Organization (WHO) has indicated that the emergence of chikungunya in Italy's northeast region of Ravenna in 2007 -- the first occasion that the Aedes albopictus mosquito had been involved in an outbreak of human illness in Europe -- has shown that "the spread of chikungunya across continents cannot be ruled out."

Chikungunya, which was first identified in Tanzania in 1953, is endemic in parts of Africa and Asia. The chikungunya virus is transmitted to humans through the bite of an infected mosquito. The Aedes albopictus mosquito, also known as the Asian tiger mosquito, was the primary carrier of the virus in the recent outbreak in Italy. The Asian tiger mosquito population has increased in the U.S. and is now commonly found in southern and eastern regions of the country. Another Aedes mosquito, A. aegypti, is responsible for outbreaks in Asia and Africa, and also is found in the U.S., primarily in southern states.

A leader in diagnostic testing for emerging infectious diseases, Focus Diagnostics has collaborated with the CDC, the WHO and other public health agencies to help identify and develop diagnostic tests for emerging infectious diseases. Focus Diagnostics was instrumental in developing the first laboratory developed test for West Nile Virus after it was identified in New York in 1999. Focus Diagnostics also introduced the first laboratory developed test for SARS and the first FDA-cleared serological test kit for Lyme disease.

About Focus Diagnostics

Focus Diagnostics, Inc. is an infectious disease diagnostics company, providing reference laboratory services to hospitals and laboratories nationwide, and manufacturing and distributing diagnostic products worldwide. Focus Diagnostics develops innovative tests and products to assist physicians in diagnosing infectious diseases, and often provides the first diagnostic tests in the U.S. for emerging diseases, such as West Nile Virus and SARS. HerpeSelect(R) type-specific HSV serology and West Nile Virus DxSelect(TM) are top-selling Focus Diagnostics products used in laboratories worldwide. Focus Diagnostics is a wholly owned subsidiary of Quest Diagnostics. Visit for additional information.

About Quest Diagnostics

Quest Diagnostics is the leading provider of diagnostic testing, information and services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic testing services through its national network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in developing innovative new diagnostic tests and advanced healthcare information technology solutions that help improve patient care. Additional company information is available at:

The statements in this press release that are not historical facts or information may be forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause actual results and outcomes to be materially different. Certain of these risks and uncertainties may include, but are not limited to, competitive environment, changes in government regulations, changing relationships with customers, payers, suppliers and strategic partners and other factors described in the Quest Diagnostics Incorporated 2006 Form 10-K and subsequent SEC filings.

SOURCE Quest Diagnostics
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