Navigation Links
Five-Year Data Demonstrate Long-Term Efficacy and Safety with ORENCIA(R) (abatacept) in Adults with Rheumatoid Arthritis Who had an Inadequate Response to Methotrexate
Date:11/9/2007

ear 1 and maintained at Year 5.

The safety analysis represents five years of cumulative data. This includes all patients who received at least one dose of ORENCIA during the one-year double-blind period and all patients who entered the open-label period who received at least one dose of ORENCIA plus all patients randomized to receive placebo (n=287). The incidence rates observed during the five-year cumulative period for serious adverse events (SAEs), infections, serious infections, malignancies and autoimmune events were consistent with both the double-blind period and the integrated safety summary, which is comprised of seven core RA studies representing approximately 8,400 patient years of exposure. The incidence rates for SAEs in the double-blind period, five-year cumulative period and the integrated safety summary were 20/100 pt-years, 18.9/100 pt-yrs and 15.4/100 pt-yrs, respectively. The incidence rates for infections in the double-blind period, five-year cumulative period and the integrated safety summary were 94.2/100 pt-years, 77.3/100 pt-yrs and 79.2/100 pt-yrs, respectively. The incidence rates for serious infections in the double-blind period, five-year cumulative period and the integrated safety summary were 2.1/100 pt-years, 3.0/100 pt-yrs and 3.0/100 pt-yrs, respectively. The incidence rates for malignancies in the double-blind period, five-year cumulative period and the integrated safety summary were 2.1/100 pt- years, 1.5/100 pt-yrs and 1.3/100 pt-yrs, respectively. A total of 12 autoimmune disorders, the most frequent of which were psoriasis and cutaneous vasculitis, were reported in 12 patients in the cumulative study period.

During the five-year cumulative period, 32 patients (11.1 percent) discontinued due to SAEs. A total of five deaths occurred through five years of the study; all were considered to be unlikely related or unrelated to study medication.

About ORENCIA(R) (abatacept)

ORENCIA is indicated in the United Sta
'/>"/>

SOURCE Bristol-Myers Squibb Company
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
2. Five-Year Data From Taxus II Clinical Trial Highlights Safety and Efficacy of Taxus(R) Stent Compared to Bare-Metal Stent
3. Positive Xeloda(R) Five-Year Overall Survival Study Data in the Adjuvant Treatment of Colon Cancer Presented at Leading European Cancer Meeting
4. Positive Five-Year Safety Data for TAXUS(R) Stent Reported in Boston Scientific Trial
5. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
6. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
7. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
8. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
9. Nebivolol Lowers Blood Pressure in Mild-to-Moderate Hypertensive Patients as Demonstrated in a Study Published in the Journal of Clinical Hypertension
10. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
11. R7128 Demonstrates Safety and Potent Antiviral Activity in HCV-Infected Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)...   LabStyle Innovations Corp . (OTCQB:DRIO), developer of ... appointment of Professor Richard B. Stone ... Directors. Prof. Stone brings over forty-five ... as an entrepreneur, venture capitalist public, company officer ... He currently serves on the board of directors ...
(Date:1/15/2014)... Jan. 15, 2014 Most osteoporosis patients want a ... recent online survey* sponsored by Mission Pharmacal Company. The ... Osteoporosis Foundation online support community, revealed that 74 percent ... comes in a form other than a pill or ...
(Date:1/15/2014)... LAWRENCEVILLE, N.J. , Jan. 15, 2014  Celsion Corporation (the ... it has received commitments from institutional investors to purchase ... common stock in an at-the-market registered direct offering, led ... Company entered into definitive purchase agreements with these investors ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... Reportlinker.com announces that a new market research ... Advanced Drug Delivery Markets (Liposomes, Polymers and ... Drug delivery is evolving at a ... discovered frequently. Advanced drug delivery deals with developing ...
... Jan. 11, 2011 Reportlinker.com announces that a ... catalogue: France Pharmaceutical Market Overview ... http://www.reportlinker.com/p0360215/France-Pharmaceutical-Market-Overview-–--Austerity-measures-will-impact-pharmaceutical-market-growth.html ... pharma market in France was valued at $38.8bn ...
Cached Medicine Technology:Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 2Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 3Reportlinker Adds France Pharmaceutical Market Overview - Austerity measures will impact pharmaceutical market growth 2
(Date:7/11/2014)... 2014 Alliance for Cancer Gene ... dedicated exclusively to cell and gene therapies for ... joined the organization as Senior Development Officer. , ... experience securing gifts and addressing influential donors. Prior ... Director for NewYork Presbyterian Hospital/Columbia University Medical Center, ...
(Date:7/11/2014)... As reported by the New York Times ... number of severe adverse events such as renal failure, ... from the highly-promoted and costly immune-system drug, Acthar, have ... , a regulatory filing revealed that the total number ... 14% of prescriptions, up from 9.1% in 2011. Specifically, ...
(Date:7/11/2014)... surgery to repair damage to the anterior cruciate ligament (ACL) ... -- could increase a young athlete,s risk for further injuries, ... patients, aged 8 to 16, who had ACL reconstruction surgery. ... after their injury, 37 had surgery six to 12 weeks ... after their injury. The youngsters who had surgery later ...
(Date:7/11/2014)... 2014 Riverside Health System became the first ... Virginia in late 2012 and now, in partnership with Williamsburg ... throughout the Williamsburg and Newport News region. , Also known ... benefits to independent older adults who wish to remain in ... net of continuing care services as well as control over ...
(Date:7/11/2014)... unravel mechanisms that guide function and differentiation of blood ... including our immune system. The study of human blood ... found in the bone marrow in specialized "niches" that ... group of scientists from Dresden led by stem cell ... to generate a mouse model that supports the transplantation ...
Breaking Medicine News(10 mins):Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Opening-up the stem cell niche 2
... and ISMANING, Germany, Oct. 17 /PRNewswire-FirstCall/,-- XIRING ... security solutions,for remote transactions, and SCM Microsystems ... of solutions that open the Digital,World, today ... eHealth,smart card terminals for the new generation ...
... today filed an amicus brief on behalf of ten ... RU-486., AUL President Dr. Charmaine Yoest stated, "RU-486 ... women,s lives. We must put a stop to,abortionists, dangerous, ... in the right direction, and as we argue in ...
... into any grocery store,and there,s likely to be ... struggle with mindless eating have already begun to ... people find that Halloween spurs,a particularly tough time ... coming, it,only becomes more challenging. Dieters, mindless eaters, ...
... SPRINGFIELD, Mass., Oct. 16 With a combination ... become its hallmark, Massachusetts Mutual Life Insurance Company,(MassMutual) ... to the cause,of Breast Cancer Awareness Month., ... contribute tens of thousands,of dollars to cancer research, ...
... Alert Urges HR/Leadership Development to Implement Post-Crash Development Programs with ... ... Gainesville, FL (PRWEB) October 16, 2008 -- ... and how human resources and leadership development can quickly ...
... researcher, clinical nutritionist and women,s health practitioner, has ... Revitalizer, designed to bring back thicker, fuller hair ... Nails Revitalizer is available exclusively through Doctors, Preferred, ... one of the largest North American direct-mail supplement ...
Cached Medicine News:Health News:XIRING and SCM Microsystems Jointly Develop Mobile Terminals for German eHealth Market 2Health News:XIRING and SCM Microsystems Jointly Develop Mobile Terminals for German eHealth Market 3Health News:Ohio's Regulation of RU-486 Clear and Constitutional, Should Be Upheld Argues AUL in Brief Filed Before Ohio Supreme Court 2Health News:A Mindful Chocolate Meditation 2Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 2Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 3Health News:Donations, Education, and People-Power Mark MassMutual Breast Cancer Awareness Month Efforts 4Health News:Perth Leadership Institute Issues Alert on the Post-Crash Environment Facing HR/Leadership Development 2Health News:Perth Leadership Institute Issues Alert on the Post-Crash Environment Facing HR/Leadership Development 3Health News:Dr. Lark Creates Nutritional Supplement to Restore Thick Hair and Strong Nails 2Health News:Dr. Lark Creates Nutritional Supplement to Restore Thick Hair and Strong Nails 3
... an innovative, quick and easy automated ... 60% less space on your laboratory ... this amazingly easy-to-use, one-hand system, you ... whole range of Diamond Tips. All ...
200 L, Racked, Pre-sterilized, 96 tips/rack, clear Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
MBP's equivalent to the "Universal Yellow" tip, this 200 L tip utilizes a MicroPoint design for accurate sample handling. 10 L Ref. mark....
For the quantitative determination of luteinizing hormone (LH) concentration in human serum....
Medicine Products: