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First Results From Ongoing Phase III Trial Show Malaria Vaccine Candidate, RTS,S* Reduces the Risk of Malaria by Half in African Children Aged 5 to 17 Months
Date:10/18/2011

ts demonstrate the power of working with partners to create a malaria vaccine that has the potential to protect millions of children from this devastating disease."

The vaccine is being developed in partnership by GSK and the PATH Malaria Vaccine Initiative (MVI), together with prominent African research centers. The partners are all represented on the Clinical Trials Partnership Committee, which is responsible for the conduct of the trial. Major funding for clinical development comes from a grant by the Bill & Melinda Gates Foundation to MVI. An extended team of organisations continues to work on RTS,S, including scientists from across Europe, North America and Africa. Should it be approved by regulatory authorities and recommended by the World Health Organisation (WHO), it will be used for African children, who are most at risk from the disease. Successful development of an effective vaccine to be used alongside other measures such as bed nets and anti-malarial medicines would represent a decisive step toward sustained malaria control.

The impact of the RTS,S Phase III trial extends beyond the vaccine being researched. The trial has made a considerable contribution to many of the African communities that host the trial sites through improved healthcare and hospital facilities. Research capacity at many of the research centres has been strengthened through the training of staff, provision of state-of-the-art laboratories, equipment, and construction of new facilities. This enhanced capacity bodes well for the centres to expand further their leadership in developing remedies for malaria and other infectious diseases for years to come.

Looking ahead GSK and MVI are committed to making this vaccine available to those who need it most, should it be approved and recommended for use. In January 2010, GSK announced that the eventual price of RTS,S will cover the cost of manufacturing the vaccine together with a small return of around 5% that w
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SOURCE GlaxoSmithKline
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