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First Prospective Cancer Monitoring Data Released - Indicating that Oncogene Mutation Signal in Urine Correlates with Response to Therapy
Date:10/21/2013

assays have potentially strong clinical utility," said Antonius Schuh, Ph.D., chief executive officer of Trovagene. "Urine as a systemic sample solves the potential problems associated with tumor heterogeneity and may offer a more complete genomic picture for the treating physician. Initial longitudinal results demonstrate that the quantity of mutations found in urine correlates with the patient's responsiveness to treatment."

The second study conducted evaluated the feasibility of using massively parallel deep sequencing (i.e., next generation sequencing) to identify DNA mutations in the urine of metastatic cancer patients harboring known KRAS mutations. Leveraging proprietary enrichment methods, the researchers were able to detect mutant cell-free DNA in the urine of cancer patients with verified KRAS mutations.

"Taken together, these two studies show that our technology can both detect and quantify the relative amount of cell-free BRAF and cell-free KRAS mutations in urine with clinically relevant sensitivity," said Mark Erlander, PhD, chief scientific officer of Trovagene. "They also provide initial clinical evidence that cell-free DNA markers from urine correlate with the patient's course of disease, and may prove to be useful tools for monitoring therapeutic response."

Dr. Janku's abstracts, "Detection and monitoring of BRAF and KRAS mutations in cell-free urinary DNA of metastatic cancer patients by digital droplet PCR" and "Non-invasive tumor mutation detection of cell-free urinary DNA using massively parallel deep DNA sequencing", are available online through the AACR website, www.AACR.org

Trovagene operates a CLIA-certified, CAP-accredited testing laboratory in San Diego, California.  The Cell-Free BRAF V600E mutation assay is available and can be ordered as a laboratory-developed test (LDT).  Visit

SOURCE Trovagene, Inc.
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