First Patient Enrolled in Global Phase III Study of Bevacizumab and Trastuzumab in Early Bre...(CLA. Slamon and fellow scientists havede...),Health

Date:5/27/2008

CLA. Slamon and fellow scientists have developed and adapted preclinical models which allow for the validation of molecular markers, the preclinical assessment of new biologic agents and the characterization of an agent's mechanisms of action. This preclinical work, in turn, generates the clinical hypotheses for the group's future cancer trials in patients. This translational approach has been used in the BCIRG 006 study and the newly-launched BETH clinical trial.

TRIO is dedicated to advancing translational cancer research by bringing innovative and targeted therapeutics to clinical practice. Additional information is available on the Internet at http://www.trioncology.org.

ABOUT THE NATIONAL SURGICAL ADJUVANT BREAST AND BOWEL PROJECT (NSABP)

Headquartered in Pittsburgh, Pennsylvania, USA, the National Surgical Adjuvant Breast and Bowel Project (NSABP) is a clinical trials cooperative group. The NSABP has a 50-year history of designing and conducting clinical research trials that have changed the way breast cancer is treated and, more recently, prevented.

With research sites at nearly 1,000 major medical centers, university hospitals, large oncology practice groups, and health maintenance organizations in the United States, Canada, Puerto Rico, and Ireland, the NSABP has enrolled more than 110,000 women and men in clinical trials in breast and colorectal cancer. More than 5,000 physicians, nurses, and other medical professionals conduct NSABP treatment and prevention trials.

NSABP breast cancer studies led to the establishment of lumpectomy plus radiation over radical mastectomy as the standard surgical treatment for breast cancer. In addition, the NSABP was the first to demonstrate that adjuvant therapy could alter the natural history of breast cancer, thereby increasing survival rates. The group was also the first to conduct large scale breast cancer prevention studies that
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SOURCE National Surgical Adjuvant Breast and Bowel Project Copyright©2008 PR Newswire. All rights reserved

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